# Biossance Squalane + Ectoin Overnight Rescue for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Biossance](https://lovi.care/skincare/sa/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/sa/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your combination skin, as squalane and glycerin hydrate and enhance barrier resilience, though it lacks stronger ingredients for oil control.
- The formula provides general skincare benefits supportive for acne-prone skin, but it does not contain targeted ingredients to effectively address acne, blemishes, and breakouts.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like ectoine and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Ectoin, Glycerin, Shorea Stenoptera Seed Butter, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37539499/))
- Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control. ([Biomedicines, 2026](https://pubmed.ncbi.nlm.nih.gov/42792808/))
- Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Most users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Absorbs well (often mentioned)
- Liked: Plumps and softens (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Disliked: High price point (sometimes noted)
- Disliked: Heavy or greasy (rarely noted)
- Disliked: Jar packaging (rarely noted)
- Disliked: May cause breakouts (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Biossance Squalane + Ectoin Overnight Rescue work for acne-prone skin?

Biossance Squalane + Ectoin Overnight Rescue works reasonably well for acne-prone skin, providing moderate hydration and a safe profile without harsh ingredients, though it lacks targeted components to manage breakouts. Acne-prone skin requires products that combine oil control and targeted blemish-fighting ingredients alongside soothing hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

Squalane, glycerin, and ectoin make this cream a good fit by providing gentle hydration and calming dry areas without causing irritation. However, acne-prone skin needs targeted ingredients to effectively address breakouts and control oil.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What does Ectoin do for acne-prone skin?

Ectoin helps acne-prone skin by acting as a protective agent that calms irritation and strengthens the skin barrier. It is unlikely to clog pores and may help keep skin smooth and comfortable while you manage breakouts. Acne-prone skin of this type needs lightweight hydrators and soothing ingredients to balance moisture without feeling heavy or greasy.
Sources: [Clinics in Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18691511/), [Arhiv Za Higijenu Rada I Toksikologiju, 2016](https://pubmed.ncbi.nlm.nih.gov/28033102/)

### Where does it go in a skincare routine for acne-prone skin?

This moisturizing treatment goes in the evening routine as the final step after your treatment serum. This type of product works for acne-prone skin by providing gentle hydration, but to properly manage blemishes it needs targeted ingredients for oil control and breakouts.

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol to keep your skin soft and calm while reducing dryness. Apply your retinol first, let it absorb, and then smooth on this cream to help buffer potential irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use it?

You can use this moisturizing treatment in your evening routine, applying it daily as your last step or after your serum. Daily application of moisturizers of this type helps keep skin soft and supports barrier function.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause breakouts or clog pores on acne-prone skin, as it has a very low risk of heavy or greasy feel and contains soothing ingredients like ectoin and glycerin. However, because it lacks targeted ingredients for oil control and blemishes, acne-prone skin needs a product with specialized blemish-fighting ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use it around the eyes or on my body?

This product is safe to use around the eyes and on the body, though it is formulated primarily as a facial moisturizing treatment. Because the skin on the eyelids is among the thinnest on the entire body, gentle and well-tolerated formulas like this one are well-suited for delicate areas without causing irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/sa/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — SAR 78.95 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/sa/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — SAR 14.95 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/sa/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — SAR 146.71 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/sa/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — SAR 53.04 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/sa/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — SAR 75.00 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin