# BIOEFFECT EGF Serum for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [BIOEFFECT](https://lovi.care/skincare/sa/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent for your normal skin, this serum's Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 promote significant skin regeneration to effectively minimize fine lines and wrinkles.
- Glycerin and Sodium Hyaluronate further enhance hydration and smoothness, supporting the plumping effects for your skin.
- The formula is safe for your skin, containing no harsh ingredients and featuring soothing components like Glycerin and Sodium Hyaluronate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/oily-acne-prone-skin): High

## Key ingredients

Rh-Oligopeptide-1, Glycerin, Sodium Hyaluronate, Hordeum Vulgare Seed Extract, Tromethamine

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Lidocaine at 20% and lidocaine 10% with trometamol provided effective pain control comparable to lidocaine/prilocaine in healthy adults after a 60-minute exposure, while propylene glycol did not accelerate the onset of analgesia. ([Journal of Pain Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28546768/))
- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))
- Ketorolac tromethamine poloxamer hydrogel provided sufficient bioavailability to reach the site of action with anti-inflammatory efficacy and no visual skin irritation in volunteers. ([Pharmaceutical Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28540502/))

## What reviewers say

Users with dry, mature, or dehydrated skin highly praise this serum for its deep hydration, plumping effects, and ability to reduce fine lines, resulting in a radiant complexion. Some users with oily or combination skin find the texture sticky or heavy.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Too heavy (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BIOEFFECT EGF Serum one of the best fits for mature skin?

This serum is one of the best fits for mature skin because its Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 help promote significant skin regeneration to minimize fine lines and wrinkles. Glycerin and Sodium Hyaluronate further enhance hydration and smoothness to support plumping effects.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit because Rh-Oligopeptide-1 and Barley Sh-Oligopeptide-1 promote significant skin regeneration to effectively minimize fine lines and wrinkles. Glycerin and Sodium Hyaluronate further enhance hydration and smoothness, supporting plumping effects for your skin.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does EGF do for mature skin?

For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28204807/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to help smooth and hydrate, followed by your retinol. The formula is safe and gentle, making it unlikely to cause irritation when paired with a retinoid.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

Use this serum in the evening. This timing is best for simplicity and extra safety around sun exposure.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and features soothing components like glycerin and sodium hyaluronate. The formula has a safe profile with a very low likelihood of feeling too heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

No store in Saudi Arabia has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Hyaluronate, Tromethamine, Sodium Chloride, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/bioeffect/egf-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/bioeffect/egf-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/bioeffect/egf-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/bioeffect/egf-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/bioeffect/egf-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/bioeffect/egf-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioeffect/egf-serum/for/mature-skin