# Anua Niacinamide 10% + TXA 4% Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Anua](https://lovi.care/skincare/sa/brands/anua)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your normal skin due to the presence of niacinamide and glycerin, which provide humectant action and seboregulation, addressing your concerns about wrinkles and fine lines by improving skin texture.
- The serum also contains hyaluronic acid, which further enhances hydration and contributes to a smoother appearance, complementing the niacinamide's brightening effects.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Txa Tranexamic Acid, Hyaluronic Acid, Panthenol, Allantoin

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective at fading post-acne marks and evening out skin tone, with many users reporting a radiant glow within weeks. While generally well-tolerated and hydrating for many, a significant number of users find the serum leaves a sticky residue, and a smaller portion experience breakouts or irritation, possibly due to the high niacinamide concentration.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Brightens skin (often mentioned)
- Disliked: Sticky finish (often mentioned)
- Liked: Hydrating (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Anua Niacinamide 10% + TXA 4% Serum a great fit for mature skin?

This serum is a great fit for mature skin because it features niacinamide and glycerin to smooth out fine lines and wrinkles while keeping skin texture soft. It also has hyaluronic acid to boost hydration for a more plump, smooth look, and it is very safe and gentle to use.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains niacinamide and hyaluronic acid, which help smooth out fine lines and wrinkles while boosting hydration. Glycerin also helps keep the skin soft and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Tranexamic Acid do for mature skin?

Tranexamic acid helps reduce brown spots and uneven tone while improving overall skin brightness. Studies show that using it regularly can fade stubborn pigmentation safely and with very little irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38549196/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and toning, and before moisturizing. It is unlikely to cause irritation on mature skin, helping to smooth fine lines and boost hydration safely.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help smooth and hydrate mature skin, followed by your retinol. This approach is unlikely to cause irritation because the formula has a very safe profile without harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### How often should I use this serum?

Use this serum in the evening as part of your routine. It has a very safe profile and is unlikely to cause irritation on normal skin, helping to smooth out fine lines and brighten your tone over time.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause irritation for your mature skin due to the absence of harsh ingredients, though a moderate number of reviewers report breakouts. It helps smooth lines and hydrate dry areas without heavy oils that typically clog pores.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — SAR 461.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/sa/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — SAR 865.37 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/sa/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — SAR 5,271.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/sa/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — SAR 191.00 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/sa/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — SAR 30.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/sa/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — SAR 329.18 at Amazon

## Where to buy

- Amazon.sa: SAR 68.00 (https://www.amazon.sa/dp/B0CVFPT7FC?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Butylene Glycol, 1,2-Hexanediol, Betaine, Panthenol, Hyaluronic Acid, Allantoin, Tocopherol, Ethylhexylglycerin, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/niacinamide-10-txa-4-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/mature-skin (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/niacinamide-10-txa-4-serum/for/mature-skin