# Anua Niacinamide 10% + TXA 4% Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Brand: [Anua](https://lovi.care/skincare/sa/brands/anua)
Category: [Serums and treatments](https://lovi.care/skincare/sa/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Offers high suitability for your normal skin as niacinamide and glycerin provide humectant action and seboregulation, addressing your pigmentation concerns with relevant benefits.
- The presence of niacinamide and tranexamic acid in moderate concentrations effectively brightens and evens skin tone, targeting hyperpigmentation.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Txa Tranexamic Acid, Hyaluronic Acid, Panthenol, Allantoin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective at fading post-acne marks and evening out skin tone, with many users reporting a radiant glow within weeks. While generally well-tolerated and hydrating for many, a significant number of users find the serum leaves a sticky residue, and a smaller portion experience breakouts or irritation, possibly due to the high niacinamide concentration.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Brightens skin (often mentioned)
- Disliked: Sticky finish (often mentioned)
- Liked: Hydrating (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Caused breakouts (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Anua Niacinamide 10% + TXA 4% Serum a great fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it uses niacinamide and tranexamic acid to brighten and even out skin tone. It also keeps skin hydrated and is unlikely to cause irritation thanks to its gentle formula.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this serum a good fit for skin with dark spots?

Niacinamide and tranexamic acid make this serum a great fit for skin with dark spots because they effectively brighten and even out skin tone. Niacinamide also helps reduce dark spots by preventing pigment from spreading in the skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Tranexamic Acid do for skin with dark spots?

Tranexamic acid helps fade dark spots and uneven patches by slowing down the signals that trigger excess pigment in the skin. Studies show that using it regularly can significantly improve skin tone with a low risk of side effects.
Sources: [Clinical and Experimental Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27135282/), [Journal of Drugs in Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31741361/)

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. Using it at night helps the ingredients target dark spots while your skin rests, and it is unlikely to cause irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, or by using them on alternating nights to keep your skin calm. The gentle ingredients in this formula help minimize any potential irritation when combining active treatments.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### How often should I use this serum?

Use this treatment serum in your evening routine, applying it once a day for simplicity and extra safety around sun exposure. It is a great fit for your skin with dark spots because ingredients like niacinamide and tranexamic acid effectively brighten and even skin tone.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum may cause breakouts for some, as reviewers note a moderate number of complaints about pimples, though it has an overall safe profile with no harsh ingredients. Sticking to a gradual introduction helps your skin adjust and lowers the likelihood of unwanted reactions.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/sa/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — SAR 461.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — SAR 226.83 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/sa/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/dark-spots) — High fit — SAR 653.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — SAR 36.33 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/sa/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — SAR 81.67 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/sa/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — SAR 58.98 at Amazon

## Where to buy

- Amazon.sa: SAR 68.00 (https://www.amazon.sa/dp/B0CVFPT7FC?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Butylene Glycol, 1,2-Hexanediol, Betaine, Panthenol, Hyaluronic Acid, Allantoin, Tocopherol, Ethylhexylglycerin, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/anua/niacinamide-10-txa-4-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/niacinamide-10-txa-4-serum/for/dark-spots (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/niacinamide-10-txa-4-serum/for/dark-spots