# Zinc and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/sa/ingredients/zinc-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Keep them apart

Use them at different times of day with [zinc](https://lovi.care/skincare/sa/ingredients/zinc) in the morning and the peptide at night, because mixing them makes the peptide less effective. Zinc can bind to the peptide and stop it from working properly on your skin. You can wait a few minutes between products or use them in separate routines to get the full benefits.

- [All about zinc](https://lovi.care/skincare/sa/ingredients/zinc)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/palmitoyl-pentapeptide-4)

### [Zinc](https://lovi.care/skincare/sa/ingredients/zinc) products

- [BYOMA Clarifying Serum](https://lovi.care/skincare/sa/p/byoma/clarifying-serum/for/dry-skin) — High fit — [SAR 101.13 at Amazon](https://www.amazon.sa/dp/B0C7C8BZLM?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/sa/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit
- [Sunday Riley Saturn Sulfur Spot Treatment Mask](https://lovi.care/skincare/sa/p/sunday-riley/saturn-sulfur-spot-treatment-mask/for/oily-acne-prone-skin) — Superior fit

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/sa/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [SAR 797.00 at Amazon](https://www.amazon.sa/dp/B07HV7CLBC?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use zinc and palmitoyl pentapeptide-4 together?

Keep [zinc](https://lovi.care/skincare/sa/ingredients/zinc) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/palmitoyl-pentapeptide-4) apart in your skincare routine because unchelated metal ions may [complex](https://lovi.care/skincare/sa/ingredients/complex) with peptides and reduce their biological activity.

### Which goes first, zinc or palmitoyl pentapeptide-4?

Keep zinc and palmitoyl pentapeptide-4 apart because unchelated metal ions may complex with peptides and reduce their biological activity.

### Are zinc and palmitoyl pentapeptide-4 good for sensitive skin?

Keep zinc and palmitoyl pentapeptide-4 apart in your routine because they may complex together and reduce their biological activity. Lovi gives them no fit rating for sensitive skin.

## Research on zinc and palmitoyl pentapeptide-4

- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc · Journal of Controlled Release, 2025
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc · Journal of Cosmetic Dermatology, 2026
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Salicylic acid and zinc](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-zinc)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/sa/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/sa/ingredients/niacinamide-and-zinc)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-zinc)
- Keep them apart: [Zinc and collagen peptide](https://lovi.care/skincare/sa/ingredients/zinc-and-collagen-peptide)
- Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/sa/ingredients/zinc-and-copper-peptide)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/sa/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/sa/ingredients/zinc-and-palmitoyl-tripeptide-1)
- Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/zinc-and-peptide-rich-plasma)
- Keep them apart: [Zinc and triple peptide blend](https://lovi.care/skincare/sa/ingredients/zinc-and-triple-peptide-blend)
- Work well together: [Benzoyl peroxide and zinc](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-zinc)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/zinc-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Germany: https://lovi.care/skincare/de/ingredients/zinc-and-palmitoyl-pentapeptide-4
- France: https://lovi.care/skincare/fr/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Spain: https://lovi.care/skincare/es/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Canada: https://lovi.care/skincare/ca/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Singapore: https://lovi.care/skincare/sg/ingredients/zinc-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/zinc-and-palmitoyl-pentapeptide-4 (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/zinc-and-palmitoyl-pentapeptide-4