# Retinal and acetyl hexapeptide-3

Page: https://lovi.care/skincare/sa/ingredients/retinal-and-acetyl-hexapeptide-3

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Keep them apart

Use them at different times of day, applying [retinal](https://lovi.care/skincare/sa/ingredients/retinal) at night and [acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3) in the morning to avoid skin irritation. Both ingredients work hard to smooth the skin, but mixing them at the same time can cause redness and stinging. You can easily fix this by using a gentler strength or simply applying them at different times of the day.

- [All about retinal](https://lovi.care/skincare/sa/ingredients/retinal)
- [All about acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3)

### [Retinal](https://lovi.care/skincare/sa/ingredients/retinal) products

- [Beauty of Joseon Revive Eye Serum](https://lovi.care/skincare/sa/p/beauty-of-joseon/revive-eye-serum/for/combination-skin) — High fit — [SAR 87.00 at Amazon](https://www.amazon.sa/dp/B0CTC25796?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/sa/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit
- [Medik8 CRYSTAL RETINAL 3](https://lovi.care/skincare/sa/p/medik8/crystal-retinal-3/for/mature-skin) — High fit — [SAR 272.46 at Amazon](https://www.amazon.sa/dp/B07Y5P314G?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Murad Retinal ReSculpt Overnight Treatment](https://lovi.care/skincare/sa/p/murad/retinal-resculpt-overnight-treatment/for/mature-skin) — Superior fit — [SAR 347.76 at Amazon](https://www.amazon.sa/dp/B0BWGXDCWJ?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [celimax RETINAL SHOT](https://lovi.care/skincare/sa/p/celimax/retinal-shot/for/acne-prone-skin) — Average fit — [SAR 79.68 at Amazon](https://www.amazon.sa/dp/B0FQV2J48Q?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Some By Mi Retinol Intense Reactivating Serum](https://lovi.care/skincare/sa/p/some-by-mi/retinol-intense-reactivating-serum/for/oily-acne-prone-skin) — High fit — [SAR 65.55 at Amazon](https://www.amazon.sa/dp/B0BXGW8DRP?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [NATURIUM Retinaldehyde Cream Serum 0.05%](https://lovi.care/skincare/sa/p/naturium/retinaldehyde-cream-serum-0-05/for/dry-skin) — Average fit — [SAR 81.35 at Amazon](https://www.amazon.sa/dp/B0BJL2W71K?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Avène RetrinAL EYES](https://lovi.care/skincare/sa/p/avene/retrinal-eyes/for/dry-skin) — High fit
- [Murad Retinal ReSculpt Body Treatment](https://lovi.care/skincare/sa/p/murad/retinal-resculpt-body-treatment/for/mature-skin) — Average fit
- [K-SECRET SEOUl 1988 EYE CREAM](https://lovi.care/skincare/sa/p/k-secret/seoul-1988-eye-cream/for/mature-skin) — Average fit — [SAR 39.90 at Amazon](https://www.amazon.sa/dp/B0G61K2B1P?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Geek & Gorgeous A-Game 5](https://lovi.care/skincare/sa/p/geek-and-gorgeous/a-game-5/for/oily-acne-prone-skin) — High fit — [SAR 116.15 at Amazon](https://www.amazon.sa/dp/B08TTP8589?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Peach & Lily Retinal For All Renewing Serum](https://lovi.care/skincare/sa/p/peach-and-lily/retinal-for-all-renewing-serum/for/dry-sensitive-skin) — Average fit — [SAR 272.27 at Amazon](https://www.amazon.sa/dp/B0CRK6TC5T?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [SAR 89.78 at Amazon](https://www.amazon.sa/dp/B0FGQFPWYN?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit
- [Medik8 Liquid Peptides](https://lovi.care/skincare/sa/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [SAR 418.50 at Amazon](https://www.amazon.sa/dp/B0DSJNWVV6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/sa/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [SAR 793.03 at Amazon](https://www.amazon.sa/dp/B076ZQ7YVB?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/sa/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [SAR 213.33 at Amazon](https://www.amazon.sa/dp/B0D5KC6LYS?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/sa/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [SAR 113.86 at Amazon](https://www.amazon.sa/dp/B091MTKS35?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/sa/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [SAR 316.97 at Amazon](https://www.amazon.sa/dp/B09FG8TJDD?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/sa/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [SAR 1,470.00 at Amazon](https://www.amazon.sa/dp/B0163GAMI4?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/sa/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [SAR 244.35 at Amazon](https://www.amazon.sa/dp/B0DB9GHK4Q?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/sa/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/sa/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [SAR 931.97 at Amazon](https://www.amazon.sa/dp/B085614WX5?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use retinal and acetyl hexapeptide-3 together?

No, you should keep [retinal](https://lovi.care/skincare/sa/ingredients/retinal) and [acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3) apart in your routine because combined stimulation may increase irritation. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning.

### Which goes first, retinal or acetyl hexapeptide-3?

Keep retinal and acetyl hexapeptide-3 apart in your routine because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the evening and peptides in the morning.

### Are retinal and acetyl hexapeptide-3 good for sensitive skin?

No, you should keep retinal and acetyl hexapeptide-3 apart in your routine because combined stimulation may increase irritation on sensitive skin. Instead, you can alternate usage by applying your retinal in the evening and your peptides in the morning.

## Research on retinal and acetyl hexapeptide-3

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and retinal](https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-retinal)
- Keep them apart: [Retinal and collagen peptide](https://lovi.care/skincare/sa/ingredients/retinal-and-collagen-peptide)
- Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/sa/ingredients/retinal-and-copper-peptide)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/sa/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/sa/ingredients/retinal-and-palmitoyl-tripeptide-1)
- Keep them apart: [Retinal and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/retinal-and-peptide-rich-plasma)
- Keep them apart: [Retinal and triple peptide blend](https://lovi.care/skincare/sa/ingredients/retinal-and-triple-peptide-blend)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/sa/ingredients/niacinamide-and-retinal)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Keep them apart: [AHA blend glycolic and citric acids and retinal](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-retinal)
- Keep them apart: [Retinal and citric acid](https://lovi.care/skincare/sa/ingredients/retinal-and-citric-acid)
- Keep them apart: [Glycolic acid and retinal](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-retinal)
- Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/sa/ingredients/retinal-and-lactic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/sa/ingredients/retinal-and-mandelic-acid)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Salicylic acid and retinal](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-retinal)
- Keep them apart: [Vitamin C and retinal](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-retinal)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Benzoyl peroxide and retinal](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-retinal)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/retinal-and-acetyl-hexapeptide-3
- United Kingdom: https://lovi.care/skincare/uk/ingredients/retinal-and-acetyl-hexapeptide-3
- Ireland: https://lovi.care/skincare/ie/ingredients/retinal-and-acetyl-hexapeptide-3
- Germany: https://lovi.care/skincare/de/ingredients/retinal-and-acetyl-hexapeptide-3
- France: https://lovi.care/skincare/fr/ingredients/retinal-and-acetyl-hexapeptide-3
- Italy: https://lovi.care/skincare/it/ingredients/retinal-and-acetyl-hexapeptide-3
- Netherlands: https://lovi.care/skincare/nl/ingredients/retinal-and-acetyl-hexapeptide-3
- Spain: https://lovi.care/skincare/es/ingredients/retinal-and-acetyl-hexapeptide-3
- Canada: https://lovi.care/skincare/ca/ingredients/retinal-and-acetyl-hexapeptide-3
- Australia: https://lovi.care/skincare/au/ingredients/retinal-and-acetyl-hexapeptide-3
- Singapore: https://lovi.care/skincare/sg/ingredients/retinal-and-acetyl-hexapeptide-3
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinal-and-acetyl-hexapeptide-3 (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinal-and-acetyl-hexapeptide-3