# Phytosphingosine and peptide-rich plasma

Page: https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-peptide-rich-plasma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Work well together

Use them together in the same routine, applying the [peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma) first and the [phytosphingosine](https://lovi.care/skincare/sa/ingredients/phytosphingosine) right after to boost results. Phytosphingosine and peptides work as a team to repair your skin barrier and make your face look firmer and smoother. If your skin feels sensitive, try applying them on alternate nights or giving them a few extra minutes to absorb.

- [All about phytosphingosine](https://lovi.care/skincare/sa/ingredients/phytosphingosine)
- [All about peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma)

### [Phytosphingosine](https://lovi.care/skincare/sa/ingredients/phytosphingosine) products

- [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/sa/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [SAR 53.59 at Amazon](https://www.amazon.sa/dp/B07C5XPXDC?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/sa/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit
- [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/sa/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [SAR 139.10 at Amazon](https://www.amazon.sa/dp/B098NP8314?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Cetaphil Ceramide Serum](https://lovi.care/skincare/sa/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [SAR 127.65 at Amazon](https://www.amazon.sa/dp/B0CZD72G5W?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/sa/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit — [SAR 48.95 at Amazon](https://www.amazon.sa/dp/B08562FW67?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/sa/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit
- [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/sa/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit

### [Peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma) products

- [Eighth Day Regenerative Serum](https://lovi.care/skincare/sa/p/eighth-day/regenerative-serum/for/dry-sensitive-skin) — High fit

## Questions and answers

### Can you use phytosphingosine and peptide-rich plasma together?

Yes, you can use [phytosphingosine](https://lovi.care/skincare/sa/ingredients/phytosphingosine) and [peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma) together because they combine for enhanced barrier support and repair. Lipids like phytosphingosine improve peptide absorption while reinforcing the skin structure.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Which goes first, phytosphingosine or peptide-rich plasma?

There is no set rule on which to apply first, but you can easily use phytosphingosine and peptide-rich plasma together because they support skin barrier repair.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Are phytosphingosine and peptide-rich plasma good for sensitive skin?

Yes, phytosphingosine and peptide-rich plasma work well together to enhance skin repair and barrier support, making them beneficial for dry, mature, and barrier-impaired skin. Combining them helps improve absorption and reinforces overall skin structure.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

## Research on phytosphingosine and peptide-rich plasma

- [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007

## Other combinations

- Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/adapalene-and-peptide-rich-plasma)
- Keep them apart: [Granactive retinoid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/granactive-retinoid-and-peptide-rich-plasma)
- Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma)
- Keep them apart: [Pro-retinol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-peptide-rich-plasma)
- Keep them apart: [Retinal and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/retinal-and-peptide-rich-plasma)
- Keep them apart: [Retinoid blend and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/retinoid-blend-and-peptide-rich-plasma)
- Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/retinol-and-peptide-rich-plasma)
- Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/tretinoin-and-peptide-rich-plasma)
- Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/vitamin-a-and-peptide-rich-plasma)
- Work well together: [Liposome and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/liposome-and-peptide-rich-plasma)
- Work well together: [Microcapsule and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/microcapsule-and-peptide-rich-plasma)
- Keep them apart: [Vitamin C and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-peptide-rich-plasma)
- Work well together: [Betaine and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/betaine-and-peptide-rich-plasma)
- Work well together: [Glycerin and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/glycerin-and-peptide-rich-plasma)
- Work well together: [Hyaluronic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid-and-peptide-rich-plasma)
- Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/niacinamide-and-peptide-rich-plasma)
- Work well together: [Panthenol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/panthenol-and-peptide-rich-plasma)
- Work well together: [Bakuchiol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/bakuchiol-and-peptide-rich-plasma)
- Work well together: [Arginine and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/arginine-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and GABA](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-gaba)
- Work well together: [Silk amino acids and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-peptide-rich-plasma)
- Work well together: [Taurine and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/taurine-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and theanine](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-peptide-rich-plasma)
- Keep them apart: [Citric acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/citric-acid-and-peptide-rich-plasma)
- Keep them apart: [Glycolic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-peptide-rich-plasma)
- Keep them apart: [Lactic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/lactic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Work well together: [Coenzyme Q10 and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/coenzyme-q10-and-peptide-rich-plasma)
- Work well together: [Green tea and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/green-tea-and-peptide-rich-plasma)
- Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-peptide-rich-plasma)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-phytosphingosine)
- Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/sa/ingredients/collagen-peptide-and-phytosphingosine)
- Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-copper-peptide)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/sa/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1)
- Work well together: [Beta-sitosterol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/beta-sitosterol-and-peptide-rich-plasma)
- Work well together: [Ceramide-building complex and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/ceramide-building-complex-and-peptide-rich-plasma)
- Work well together: [Cholesterol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/cholesterol-and-peptide-rich-plasma)
- Work well together: [Phytosterol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/phytosterol-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and squalene](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-squalene)
- Work well together: [Peptide-rich plasma and tri-ceramide complex](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-tri-ceramide-complex)
- Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-triple-peptide-blend)
- Keep them apart: [Salicylic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-peptide-rich-plasma)
- Keep them apart: [Peptide-rich plasma and baking soda](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-baking-soda)
- Keep them apart: [Bleach and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/bleach-and-peptide-rich-plasma)
- Keep them apart: [Potassium hydroxide and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/potassium-hydroxide-and-peptide-rich-plasma)
- Keep them apart: [Peptide-rich plasma and behenyl alcohol](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-behenyl-alcohol)
- Keep them apart: [Isopropyl alcohol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/isopropyl-alcohol-and-peptide-rich-plasma)
- Keep them apart: [Polyvinyl alcohol and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/polyvinyl-alcohol-and-peptide-rich-plasma)
- Keep them apart: [Copper and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/copper-and-peptide-rich-plasma)
- Keep them apart: [Magnesium and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/magnesium-and-peptide-rich-plasma)
- Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/zinc-and-peptide-rich-plasma)
- Keep them apart: [Zinc sulfate and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/zinc-sulfate-and-peptide-rich-plasma)
- Keep them apart: [Benzoyl peroxide and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-peptide-rich-plasma)
- Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-peptide-rich-plasma)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/sa/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Superoxide dismutase and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/superoxide-dismutase-and-peptide-rich-plasma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/phytosphingosine-and-peptide-rich-plasma
- United Kingdom: https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-peptide-rich-plasma
- Ireland: https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-peptide-rich-plasma
- Germany: https://lovi.care/skincare/de/ingredients/phytosphingosine-and-peptide-rich-plasma
- France: https://lovi.care/skincare/fr/ingredients/phytosphingosine-and-peptide-rich-plasma
- Italy: https://lovi.care/skincare/it/ingredients/phytosphingosine-and-peptide-rich-plasma
- Netherlands: https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-peptide-rich-plasma
- Spain: https://lovi.care/skincare/es/ingredients/phytosphingosine-and-peptide-rich-plasma
- Canada: https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-peptide-rich-plasma
- Australia: https://lovi.care/skincare/au/ingredients/phytosphingosine-and-peptide-rich-plasma
- Singapore: https://lovi.care/skincare/sg/ingredients/phytosphingosine-and-peptide-rich-plasma
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-peptide-rich-plasma (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/phytosphingosine-and-peptide-rich-plasma