# Mandelic acid and hexapeptide-9

Page: https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Keep them apart

Apply [mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) and [hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hexapeptide-9) at different times of day because the acid destroys the peptide's firmness benefits. Mandelic acid makes your skin too acidic, which breaks down hexapeptide-9 and stops it from smoothing fine lines. You can use one in the morning and the other at night to get the best results from both.

- [All about mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid)
- [All about hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hexapeptide-9)

### [Mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) products

- [The Ordinary Mandelic Acid 10% + HA](https://lovi.care/skincare/sa/p/the-ordinary/mandelic-acid-10-ha/for/acne-prone-skin) — Superior fit
- [Nécessaire The Body Retinol](https://lovi.care/skincare/sa/p/necessaire/the-body-retinol/for/dark-spots) — Average fit
- [Good Molecules Mandelic Acid Serum](https://lovi.care/skincare/sa/p/good-molecules/mandelic-acid-serum/for/dry-sensitive-skin) — Superior fit — [SAR 101.74 at Amazon](https://www.amazon.sa/dp/B0D6TWLB6T?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Glamglow Supermud Clearing Treatment](https://lovi.care/skincare/sa/p/glamglow/supermud-clearing-treatment/for/oily-skin) — High fit — [SAR 171.41 at Amazon](https://www.amazon.sa/dp/B01MT9MPTX?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Dermalogica PowerBright Dark Spot Peel](https://lovi.care/skincare/sa/p/dermalogica/powerbright-dark-spot-peel/for/oily-skin) — Average fit
- [Sofie Pavitt Face Mandelic Clearing Serum](https://lovi.care/skincare/sa/p/sofie-pavitt-face/mandelic-clearing-serum/for/oily-acne-prone-skin) — High fit
- [Cetaphil Gentle Exfoliating SA Lotion](https://lovi.care/skincare/sa/p/cetaphil/gentle-exfoliating-sa-lotion/for/combination-skin) — High fit — [SAR 132.33 at Amazon](https://www.amazon.sa/dp/B0CZDMS6G6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [SkinCeuticals Cell Cycle Catalyst](https://lovi.care/skincare/sa/p/skinceuticals/cell-cycle-catalyst/for/oily-acne-prone-skin) — Average fit
- [DIME TBT Serum](https://lovi.care/skincare/sa/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [By Wishtrend Mandelic Acid 5% Skin Prep Water](https://lovi.care/skincare/sa/p/by-wishtrend/mandelic-acid-5-skin-prep-water/for/acne-prone-skin) — High fit — [SAR 126.00 at Amazon](https://www.amazon.sa/dp/B07MC4P4R8?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Haruharu Wonder Black Rice Triple AHA Gentle Cleansing Gel](https://lovi.care/skincare/sa/p/haruharu-wonder/black-rice-triple-aha-gentle-cleansing-gel/for/oily-acne-prone-skin) — High fit — [SAR 34.21 at Amazon](https://www.amazon.sa/dp/B0CKVL9PGY?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Neutrogena Bright Boost Gel Cream](https://lovi.care/skincare/sa/p/neutrogena/bright-boost-gel-cream/for/acne-prone-skin) — High fit

### [Hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/sa/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [SAR 1,247.00 at Amazon](https://www.amazon.sa/dp/B09QH6NZ5K?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/sa/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/sa/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [SAR 54.79 at Amazon](https://www.amazon.sa/dp/B095YHYF33?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use mandelic acid and hexapeptide-9 together?

No, you should keep [mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) and [hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hexapeptide-9) apart in your routine because the acidic environment of mandelic acid can destabilize peptide bonds and reduce their effectiveness. Instead, use them in separate steps or routines, such as applying mandelic acid in the morning and hexapeptide-9 at night.

### Which goes first, mandelic acid or hexapeptide-9?

Keep mandelic acid and hexapeptide-9 apart by using them in separate routines, such as AM and PM, because the low pH of mandelic acid may break down peptide bonds and reduce the effectiveness of hexapeptide-9.

### Are mandelic acid and hexapeptide-9 good for sensitive skin?

Mandelic acid and hexapeptide-9 should be kept apart in your routine because the acidic environment of the acid may destabilize the peptide bonds. Use them in separate steps or different routines like AM and PM separation.

## Research on mandelic acid and hexapeptide-9

- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Benzoyl peroxide and mandelic acid](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-mandelic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/sa/ingredients/retinol-and-mandelic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/sa/ingredients/niacinamide-and-mandelic-acid)
- Work well together: [Mandelic acid and sodium lactate](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-sodium-lactate)
- Work well together: [Mandelic acid and tromethamine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-tromethamine)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-betaine)
- Work well together: [Glycerin and mandelic acid](https://lovi.care/skincare/sa/ingredients/glycerin-and-mandelic-acid)
- Depends on the strength: [Mandelic acid and hyaluronic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-mandelic-acid)
- Keep them apart: [Carnosine and mandelic acid](https://lovi.care/skincare/sa/ingredients/carnosine-and-mandelic-acid)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/sa/ingredients/hexapeptide-and-mandelic-acid)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and triple peptide blend](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-triple-peptide-blend)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-hexapeptide-9)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/sa/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-granactive-retinoid)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-mandelic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/sa/ingredients/retinal-and-mandelic-acid)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/sa/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Work well together: [Mandelic acid and gluconolactone](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-gluconolactone)
- Work well together: [Mandelic acid and lactobionic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-lactobionic-acid)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-hexapeptide-9)
- Work well together: [Mandelic acid and cholesterol](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-cholesterol)
- Work well together: [Mandelic acid and lauric acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/linoleic-acid-and-mandelic-acid)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/sa/ingredients/arginine-and-mandelic-acid)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-gaba)
- Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-mandelic-acid)
- Work well together: [Taurine and mandelic acid](https://lovi.care/skincare/sa/ingredients/taurine-and-mandelic-acid)
- Work well together: [Mandelic acid and theanine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-theanine)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Work well together: [Ferulic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/ferulic-acid-and-mandelic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Salicylic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-mandelic-acid)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Work well together: [Allantoin and mandelic acid](https://lovi.care/skincare/sa/ingredients/allantoin-and-mandelic-acid)
- Work well together: [Mandelic acid and bisabolol](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-bisabolol)
- Work well together: [Panthenol and mandelic acid](https://lovi.care/skincare/sa/ingredients/panthenol-and-mandelic-acid)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/mandelic-acid-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/mandelic-acid-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/mandelic-acid-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/mandelic-acid-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/mandelic-acid-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/mandelic-acid-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/mandelic-acid-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hexapeptide-9 (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/mandelic-acid-and-hexapeptide-9