# Mandelic acid and gluconolactone

Page: https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-gluconolactone

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Work well together

Use them together in the same routine, applying the [mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) first and the [gluconolactone](https://lovi.care/skincare/sa/ingredients/gluconolactone) right after, because they balance each other out. The gluconolactone adds moisture and calms the skin, which helps stop the mandelic acid from causing redness or irritation. If your skin feels too tingly, you can switch to using them on alternate nights.

[The use of polyhydroxy acids (PHAs) in photoaged skin](https://pubmed.ncbi.nlm.nih.gov/15002656/) [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/)

- [All about mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid)
- [All about gluconolactone](https://lovi.care/skincare/sa/ingredients/gluconolactone)

### [Mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) products

- [The Ordinary Mandelic Acid 10% + HA](https://lovi.care/skincare/sa/p/the-ordinary/mandelic-acid-10-ha/for/acne-prone-skin) — Superior fit
- [Nécessaire The Body Retinol](https://lovi.care/skincare/sa/p/necessaire/the-body-retinol/for/dark-spots) — Average fit
- [Good Molecules Mandelic Acid Serum](https://lovi.care/skincare/sa/p/good-molecules/mandelic-acid-serum/for/dry-sensitive-skin) — Superior fit — [SAR 101.74 at Amazon](https://www.amazon.sa/dp/B0D6TWLB6T?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Glamglow Supermud Clearing Treatment](https://lovi.care/skincare/sa/p/glamglow/supermud-clearing-treatment/for/oily-skin) — High fit — [SAR 171.41 at Amazon](https://www.amazon.sa/dp/B01MT9MPTX?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Dermalogica PowerBright Dark Spot Peel](https://lovi.care/skincare/sa/p/dermalogica/powerbright-dark-spot-peel/for/oily-skin) — Average fit
- [Sofie Pavitt Face Mandelic Clearing Serum](https://lovi.care/skincare/sa/p/sofie-pavitt-face/mandelic-clearing-serum/for/oily-acne-prone-skin) — High fit
- [Cetaphil Gentle Exfoliating SA Lotion](https://lovi.care/skincare/sa/p/cetaphil/gentle-exfoliating-sa-lotion/for/combination-skin) — High fit — [SAR 132.33 at Amazon](https://www.amazon.sa/dp/B0CZDMS6G6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [SkinCeuticals Cell Cycle Catalyst](https://lovi.care/skincare/sa/p/skinceuticals/cell-cycle-catalyst/for/oily-acne-prone-skin) — Average fit
- [DIME TBT Serum](https://lovi.care/skincare/sa/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [By Wishtrend Mandelic Acid 5% Skin Prep Water](https://lovi.care/skincare/sa/p/by-wishtrend/mandelic-acid-5-skin-prep-water/for/acne-prone-skin) — High fit — [SAR 126.00 at Amazon](https://www.amazon.sa/dp/B07MC4P4R8?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Haruharu Wonder Black Rice Triple AHA Gentle Cleansing Gel](https://lovi.care/skincare/sa/p/haruharu-wonder/black-rice-triple-aha-gentle-cleansing-gel/for/oily-acne-prone-skin) — High fit — [SAR 34.21 at Amazon](https://www.amazon.sa/dp/B0CKVL9PGY?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [The INKEY List Mandelic Acid Treatment](https://lovi.care/skincare/sa/p/the-inkey-list/mandelic-acid-treatment/for/oily-acne-prone-skin) — High fit

### [Gluconolactone](https://lovi.care/skincare/sa/ingredients/gluconolactone) products

- [CeraVe Blemish Control Cleanser](https://lovi.care/skincare/sa/p/cerave/blemish-control-cleanser/for/oily-acne-prone-skin) — Superior fit — [SAR 46.80 at Amazon](https://www.amazon.sa/dp/B0B7RQ46LD?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [SKIN1004 Madagascar Centella Toning Toner](https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-toning-toner/for/combination-skin) — Superior fit — [SAR 42.61 at Amazon](https://www.amazon.sa/dp/B07NS3T4W2?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [BYOMA Clarifying Serum](https://lovi.care/skincare/sa/p/byoma/clarifying-serum/for/dry-skin) — High fit — [SAR 101.13 at Amazon](https://www.amazon.sa/dp/B0C7C8BZLM?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [EADEM Cashmere Peel](https://lovi.care/skincare/sa/p/eadem/cashmere-peel/for/oily-skin) — Average fit
- [The INKEY List PHA Toner](https://lovi.care/skincare/sa/p/the-inkey-list/pha-toner/for/acne-prone-skin) — Superior fit — [SAR 232.00 at Amazon](https://www.amazon.sa/dp/B09PP2VLGP?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Kiehl's Hydro-Plumping Serum Concentrate](https://lovi.care/skincare/sa/p/kiehl-s/hydro-plumping-serum-concentrate/for/dry-skin) — Superior fit — [SAR 460.35 at Amazon](https://www.amazon.sa/dp/B00XDIHDDS?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/sa/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit — [SAR 241.56 at Amazon](https://www.amazon.sa/dp/B089TPYFX3?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Hero Cosmetics Pore Release Blackhead Clearing Solution](https://lovi.care/skincare/sa/p/hero-cosmetics/pore-release-blackhead-clearing-solution/for/combination-skin) — Superior fit
- [Some By Mi AHA-BHA-PHA 30 Days Miracle Acne Clear Foam](https://lovi.care/skincare/sa/p/some-by-mi/aha-bha-pha-30-days-miracle-acne-clear-foam/for/oily-acne-prone-skin) — High fit — [SAR 115.04 at Amazon](https://www.amazon.sa/dp/B0BCX7SPTD?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [OLEHENRIKSEN Truth Juice Daily Cleanser](https://lovi.care/skincare/sa/p/olehenriksen/truth-juice-daily-cleanser/for/oily-acne-prone-skin) — High fit
- [Face Reality sal-C toner](https://lovi.care/skincare/sa/p/face-reality/sal-c-toner/for/oily-acne-prone-skin) — High fit
- [Farmacy Brighten Up 3% TXA](https://lovi.care/skincare/sa/p/farmacy/brighten-up-3-txa/for/acne-prone-skin) — Average fit — [SAR 212.00 at Amazon](https://www.amazon.sa/dp/B0BZTDBLJY?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use mandelic acid and gluconolactone together?

Yes, [mandelic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid) and [gluconolactone](https://lovi.care/skincare/sa/ingredients/gluconolactone) work well together to provide gentle exfoliation and antioxidant protection. You can find them combined in the Neutrogena Bright Boost Gel Cream.

### Which goes first, mandelic acid or gluconolactone?

You can use mandelic acid and gluconolactone together, and you can find them combined in the Neutrogena Bright Boost Gel Cream. Combining them helps provide gentle exfoliation and antioxidant protection.

### Are mandelic acid and gluconolactone good for sensitive skin?

Yes, mandelic acid and gluconolactone work well together to provide gentle exfoliation and antioxidant protection. Lovi rates this combination as ideal for sensitive or reactive skin because gluconolactone acts as a humectant that helps reduce the potential irritation from the acid. You can find both ingredients in Neutrogena Bright Boost Gel Cream.

## Research on mandelic acid and gluconolactone

- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023

## Other combinations

- Keep them apart: [Benzoyl peroxide and mandelic acid](https://lovi.care/skincare/sa/ingredients/benzoyl-peroxide-and-mandelic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/sa/ingredients/retinol-and-mandelic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/sa/ingredients/niacinamide-and-mandelic-acid)
- Work well together: [Mandelic acid and sodium lactate](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-sodium-lactate)
- Work well together: [Mandelic acid and tromethamine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-tromethamine)
- Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/sa/ingredients/niacinamide-and-gluconolactone)
- Work well together: [Gluconolactone and hyaluronic acid](https://lovi.care/skincare/sa/ingredients/gluconolactone-and-hyaluronic-acid)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-betaine)
- Work well together: [Glycerin and mandelic acid](https://lovi.care/skincare/sa/ingredients/glycerin-and-mandelic-acid)
- Depends on the strength: [Mandelic acid and hyaluronic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hyaluronic-acid)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-mandelic-acid)
- Keep them apart: [Carnosine and mandelic acid](https://lovi.care/skincare/sa/ingredients/carnosine-and-mandelic-acid)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/sa/ingredients/hexapeptide-and-mandelic-acid)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and triple peptide blend](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-triple-peptide-blend)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/sa/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-granactive-retinoid)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/sa/ingredients/pro-retinol-and-mandelic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/sa/ingredients/retinal-and-mandelic-acid)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/sa/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [AHA blend glycolic and citric acids and gluconolactone](https://lovi.care/skincare/sa/ingredients/aha-blend-glycolic-and-citric-acids-and-gluconolactone)
- Work well together: [Gluconolactone and citric acid](https://lovi.care/skincare/sa/ingredients/gluconolactone-and-citric-acid)
- Work well together: [Glycolic acid and gluconolactone](https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-gluconolactone)
- Work well together: [Lactic acid and gluconolactone](https://lovi.care/skincare/sa/ingredients/lactic-acid-and-gluconolactone)
- Work well together: [Mandelic acid and lactobionic acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-lactobionic-acid)
- Work well together: [Vitamin C and gluconolactone](https://lovi.care/skincare/sa/ingredients/vitamin-c-and-gluconolactone)
- Work well together: [Mandelic acid and cholesterol](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-cholesterol)
- Work well together: [Mandelic acid and lauric acid](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/linoleic-acid-and-mandelic-acid)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/sa/ingredients/arginine-and-mandelic-acid)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-gaba)
- Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-mandelic-acid)
- Work well together: [Taurine and mandelic acid](https://lovi.care/skincare/sa/ingredients/taurine-and-mandelic-acid)
- Work well together: [Mandelic acid and theanine](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-theanine)
- Work well together: [Salicylic acid and gluconolactone](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-gluconolactone)
- Work well together: [Ferulic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/ferulic-acid-and-mandelic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/sa/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Salicylic acid and mandelic acid](https://lovi.care/skincare/sa/ingredients/salicylic-acid-and-mandelic-acid)
- Work well together: [Allantoin and mandelic acid](https://lovi.care/skincare/sa/ingredients/allantoin-and-mandelic-acid)
- Work well together: [Mandelic acid and bisabolol](https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-bisabolol)
- Work well together: [Panthenol and mandelic acid](https://lovi.care/skincare/sa/ingredients/panthenol-and-mandelic-acid)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/mandelic-acid-and-gluconolactone
- United Kingdom: https://lovi.care/skincare/uk/ingredients/mandelic-acid-and-gluconolactone
- Ireland: https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-gluconolactone
- Germany: https://lovi.care/skincare/de/ingredients/mandelic-acid-and-gluconolactone
- France: https://lovi.care/skincare/fr/ingredients/mandelic-acid-and-gluconolactone
- Italy: https://lovi.care/skincare/it/ingredients/mandelic-acid-and-gluconolactone
- Netherlands: https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-gluconolactone
- Spain: https://lovi.care/skincare/es/ingredients/mandelic-acid-and-gluconolactone
- Canada: https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-gluconolactone
- Australia: https://lovi.care/skincare/au/ingredients/mandelic-acid-and-gluconolactone
- Singapore: https://lovi.care/skincare/sg/ingredients/mandelic-acid-and-gluconolactone
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/mandelic-acid-and-gluconolactone (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/mandelic-acid-and-gluconolactone