# Sesderma vs MAËLYS

Page: https://lovi.care/skincare/sa/compare/sesderma-vs-maelys

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Sesderma and MAËLYS are distinct skincare brands offering advanced [serums](https://lovi.care/skincare/sa/ingredients/serum) and meticulously engineered formulas. Sesderma is beloved for its botanical [extracts](https://lovi.care/skincare/sa/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin best, featuring the Azelac RU Serum for acne-prone skin. Meanwhile, the brand MAËLYS delivers thoughtful care through specialized solutions that suit all skin types best, including the TOO-FINE for acne-prone skin and the RE-LURE Tight & Tone Body Serum for skin with dark spots. Both lines differ primarily in their core target audiences and specific ingredient formulations.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and MAËLYS products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg1c56da0efa).

### Popular Sesderma vs MAËLYS products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [SAR 152.67 at Amazon](https://www.amazon.sa/dp/B00987RKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### MAËLYS

- [TOO-FINE](https://lovi.care/skincare/sa/p/maelys/too-fine/for/sensitive-skin) — Low fit
- [RE-LURE Tight & Tone Body Serum](https://lovi.care/skincare/sa/p/maelys/re-lure-tight-and-tone-body-serum/for/dry-sensitive-skin) — Average fit

### Sesderma vs MAËLYS [serums](https://lovi.care/skincare/sa/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [SAR 152.67 at Amazon](https://www.amazon.sa/dp/B00987RKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### MAËLYS

- [TOO-FINE](https://lovi.care/skincare/sa/p/maelys/too-fine/for/sensitive-skin) — Low fit

## Questions and answers

### Sesderma or MAËLYS: which is better?

Sesderma offers better fit levels on this page, as its Azelac RU [Serum](https://lovi.care/skincare/sa/ingredients/serum) achieves a High fit for acne-prone skin, dark spots, and combination skin, whereas the products on this page from MAËLYS mostly rate Low or Caution.

### What is the difference between Sesderma and MAËLYS?

Sesderma has a High Lovi fit for acne-prone skin and skin with dark spots with its Azelac RU Serum, whereas the products on this page from MAËLYS generally show low fits or caution across those same skin types. [Azelaic acid](https://lovi.care/skincare/sa/ingredients/azelaic-acid) helps treat acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which is more affordable, Sesderma or MAËLYS?

Neither Sesderma nor MAËLYS is described as more affordable on this page, as pricing details are not provided for the products.

### Which causes fewer breakouts, Sesderma or MAËLYS?

Sesderma causes fewer breakouts because the products on this page earn a High fit for acne-prone skin, whereas MAËLYS options are rated Low for that skin type.

### Which brand has been around longer, Sesderma or MAËLYS?

Sesderma has been around longer, having been founded in Spain in 1989, whereas MAËLYS was founded in 2017.

### Do Sesderma and MAËLYS products contain fragrance?

Yes, both Sesderma and MAËLYS offer products on this page that contain fragrance. Specifically, Sesderma includes fragrance in its Azelac RU Serum, while MAËLYS includes it in the RE-LURE Tight & Tone Body Serum.

### Which brand offers a serum with a High Lovi fit level for skin with dark spots?

Sesderma offers a serum with a High Lovi fit level for skin with dark spots.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome](https://pubmed.ncbi.nlm.nih.gov/33526970/) Lactobacillus · International Journal of Medical Sciences, 2021
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/35384257/) Lactobacillus · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaluation of a retinol containing topical treatment to improve signs of neck aging](https://pubmed.ncbi.nlm.nih.gov/37461826/) Glaucine · Journal of Cosmetic Dermatology, 2023
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin](https://pubmed.ncbi.nlm.nih.gov/37584260/) Glaucine · Journal of Cosmetic Dermatology, 2023

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/sa/brands/sesderma)
- Skincare: [MAËLYS](https://lovi.care/skincare/sa/brands/maelys)

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- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sa/compare/la-roche-posay-vs-sesderma)
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- [Dr. Althea vs Sesderma](https://lovi.care/skincare/sa/compare/dr-althea-vs-sesderma)
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- [Some By Mi vs Sesderma](https://lovi.care/skincare/sa/compare/some-by-mi-vs-sesderma)
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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-maelys
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-maelys
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-maelys
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-maelys
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-maelys
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-maelys
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-maelys
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-maelys
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-maelys
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-maelys
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-maelys
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-maelys (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-maelys