# Pixi vs Sesderma

Page: https://lovi.care/skincare/sa/compare/pixi-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Pixi and Sesderma are distinguished skincare brands that bring purposeful formulations to daily routines. The British brand founded in 1999 offers gentle toners, [serums](https://lovi.care/skincare/sa/ingredients/serum), eye products, and moisturizers that suit oily and sensitive skin best, featuring standout solutions like the Glow Tonic for acne-prone skin, the Glow Peel Pads for dark spots, and the [Retinol](https://lovi.care/skincare/sa/ingredients/retinol) Tonic for mature skin. Conversely, the Spanish brand founded in 1989 specializes in advanced serums for sensitive, hyperpigmented, and aging skin, utilizing botanical [extracts](https://lovi.care/skincare/sa/ingredients/extract) and active compounds such as the Azelac RU Serum for acne-prone skin. While both deliver radiant complexions, they differ through the British line focusing on balanced, everyday care and the latter employing meticulously engineered compounds to refine skin texture.

Pixi is a British skincare brand founded in 1999.

[pixibeauty.com](https://www.pixibeauty.com/pages/about-us) [tracxn.com](https://tracxn.com/d/companies/pixi/__9im1wKbH2BlPhvu7p7lH3hjmApgKsoxMqsd9FqFjrCE) [pitchbook.com](https://pitchbook.com/profiles/company/454901-05)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Pixi and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg4ff2486372).

### Popular Pixi vs Sesderma products

#### Pixi

- [Glow Tonic](https://lovi.care/skincare/sa/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [SAR 56.52 at Amazon](https://www.amazon.sa/dp/B09SN5B88W?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [DetoxifEYE Depuffing Eye Patches](https://lovi.care/skincare/sa/p/pixi/detoxifeye-depuffing-eye-patches/for/oily-skin) — High fit — [SAR 124.84 at Amazon](https://www.amazon.sa/dp/B07S3BT21Z?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Hydrating Milky Mist](https://lovi.care/skincare/sa/p/pixi/hydrating-milky-mist/for/sensitive-skin) — Superior fit — [SAR 136.00 at Amazon](https://www.amazon.sa/dp/B09RKTHTD8?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Glow Mist](https://lovi.care/skincare/sa/p/pixi/glow-mist/for/dry-sensitive-skin) — High fit
- [Glow Peel Pads](https://lovi.care/skincare/sa/p/pixi/glow-peel-pads/for/dark-spots) — Superior fit
- [Rose Oil Blend](https://lovi.care/skincare/sa/p/pixi/rose-oil-blend/for/dry-skin) — High fit
- [Vitamin-C Serum](https://lovi.care/skincare/sa/p/pixi/vitamin-c-serum/for/dark-spots) — High fit — [SAR 167.00 at Amazon](https://www.amazon.sa/dp/B07Q3NS7LV?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Retinol Tonic](https://lovi.care/skincare/sa/p/pixi/retinol-tonic/for/mature-skin) — Superior fit — [SAR 77.55 at Amazon](https://www.amazon.sa/dp/B07FPQJDPH?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [SAR 152.67 at Amazon](https://www.amazon.sa/dp/B00987RKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Pixi or Sesderma: which is better?

Pixi offers a much wider range of products on this page across different skincare categories, whereas Sesderma is represented by just one [serum](https://lovi.care/skincare/sa/ingredients/serum). Lovi gives Pixi superior ratings for specific items like [Retinol](https://lovi.care/skincare/sa/ingredients/retinol) Tonic and Glow Tonic on mature and acne-prone skin, while Azelac RU Serum from Sesderma achieves high fits for acne-prone skin and dark spots.

### What is the difference between Pixi and Sesderma?

Pixi offers a much larger variety of products on this page across multiple categories like toners, serums, and mists, whereas Sesderma is represented by just one serum. Additionally, Pixi's products on this page often avoid added fragrance, while Sesderma's sole product includes fragrance.

### Which is more affordable, Pixi or Sesderma?

The provided page facts and studies do not contain pricing information, so it is not possible to determine whether Pixi or Sesderma is more affordable.

### Which causes fewer breakouts, Pixi or Sesderma?

When it comes to acne-prone skin, the products on this page by Pixi achieve a Superior fit with Retinol Tonic and Glow Tonic, whereas Sesderma's Azelac RU Serum holds a High fit. Reviewers mention that Pixi offers gentle and soothing toners, though strong fragrances and skin sensitivity are sometimes noted.

### Between Pixi and Sesderma, which brand offers a wider variety of products on this page?

Pixi offers a much wider variety of products on this page, featuring ten different items ranging from toners and serums to eye patches and moisturizers. In contrast, Sesderma only features a single product on this page, the Azelac RU Serum.

### How do the founding countries and years of Pixi and Sesderma compare?

Pixi was founded in the United Kingdom in 1999, while Sesderma was established in Spain a decade earlier in 1989.

### Which of the two brands includes products that list no fragrance?

Pixi includes products on this page that list no fragrance, whereas Azelac RU Serum by Sesderma contains fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [Hyaluronic acid and wound healing](https://pubmed.ncbi.nlm.nih.gov/25877441/) Sodium hyaluronate · Journal of Pharmacy & Pharmaceutical Sciences, 2015
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review](https://pubmed.ncbi.nlm.nih.gov/30666070/) Aloe barbadensis leaf juice · Iranian Journal of Medical Sciences, 2019
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice, Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Sambucus nigra L. ameliorates UVB-induced photoaging and inflammatory response in human skin keratinocytes](https://pubmed.ncbi.nlm.nih.gov/31512082/) Sambucus nigra extract · Cytotechnology, 2019
- [Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration](https://pubmed.ncbi.nlm.nih.gov/25143733/) Argania spinosa kernel oil · International Journal of Nanomedicine, 2014
- [Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract](https://pubmed.ncbi.nlm.nih.gov/28280300/) Punica granatum seed oil · Drug Design, Development and Therapy, 2017
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel leaf extract, Witch hazel extract · Phytochemistry, 2001
- [Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin](https://pubmed.ncbi.nlm.nih.gov/34803425/) Panax ginseng root extract · Journal of Ginseng Research, 2021
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors](https://pubmed.ncbi.nlm.nih.gov/33081083/) Rose extract · Molecules, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study](https://pubmed.ncbi.nlm.nih.gov/36677961/) Punica granatum seed oil · Molecules, 2023
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits](https://pubmed.ncbi.nlm.nih.gov/36293365/) Betula alba juice · International Journal of Molecular Sciences, 2022
- [Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/39064646/) Vaccinium myrtillus fruit extract · Nutrients, 2024
- [Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect](https://pubmed.ncbi.nlm.nih.gov/14550884/) Hexyl nicotinate · European Journal of Pharmaceutical Sciences, 2003
- [Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil](https://pubmed.ncbi.nlm.nih.gov/24451077/) Rosa damascena oil flower · Acta Pharmaceutica, 2013
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia sinensis leaf extract · Molecules, 2024
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Hexyl-nicotinate-induced vasodilation in normal human skin](https://pubmed.ncbi.nlm.nih.gov/3582710/) Hexyl nicotinate · Dermatologica, 1987
- [Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling](https://pubmed.ncbi.nlm.nih.gov/32895882/) Cucumis sativus extract · AAPS PharmSciTech, 2020
- [The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon](https://pubmed.ncbi.nlm.nih.gov/3203071/) Hexyl nicotinate · The British Journal of Dermatology, 1988
- [Clinical study of a spray containing birch juice for repairing sensitive skin](https://pubmed.ncbi.nlm.nih.gov/36961534/) Betula alba juice · Archives of Dermatological Research, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Argania spinosa kernel oil · Lasers in Medical Science, 2025

## The brands

- British skincare: [Pixi](https://lovi.care/skincare/sa/brands/pixi)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/sa/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/pixi-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/pixi-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/pixi-vs-sesderma
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- Singapore: https://lovi.care/skincare/sg/compare/pixi-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/pixi-vs-sesderma (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/compare/pixi-vs-sesderma