# Medicube vs Simple

Page: https://lovi.care/skincare/sa/compare/medicube-vs-simple

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Medicube and Simple are established skincare brands offering distinct approaches to daily routines through thoughtfully formulated moisturizers, [serums](https://lovi.care/skincare/sa/ingredients/serum), toners, and cleansers. The Korean brand is renowned for targeted products featuring [niacinamide](https://lovi.care/skincare/sa/ingredients/niacinamide), [collagen](https://lovi.care/skincare/sa/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid) that balance sebum for oily and acne-prone skin, while the British brand relies on niacinamide and [glycerin](https://lovi.care/skincare/sa/ingredients/glycerin) to deliver gentle, skin-loving formulations suited for similar skin types. Ultimately, both utilize key ingredients like niacinamide to reduce hyperpigmentation and improve aging signs, yet they differ in their origin, specialized offerings, and exact supportive compounds.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

Simple is a British skincare brand founded in 1960 and owned by Unilever PLC since 2011.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Simple_Skincare) [sec.gov](https://www.sec.gov/Archives/edgar/data/1368457/000119312511134453/dex991.htm) [prnewswire.com](https://www.prnewswire.com/news-releases/alberto-culver-announces-that-unilever-has-received-approval-from-the-us-department-of-justice-to-complete-the-acquisition-of-the-company-121400884.html) [simple.co.uk](https://www.simple.co.uk/philosophy.html)

This page compares some of the most popular Medicube and Simple products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga101e7b4e1).

### Popular Medicube vs Simple products

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/sa/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [SAR 64.80 at Amazon](https://www.amazon.sa/dp/B0CVRCR6VF?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [SAR 41.77 at Amazon](https://www.amazon.sa/dp/B0DBF65JYY?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/sa/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [SAR 48.10 at Amazon](https://www.amazon.sa/dp/B0F4PNBXLZ?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/sa/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/sa/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [SAR 68.00 at Amazon](https://www.amazon.sa/dp/B0DT6Y6QC5?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/sa/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [SAR 64.14 at Amazon](https://www.amazon.sa/dp/B0D2Z3GGCY?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/sa/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [SAR 55.25 at Amazon](https://www.amazon.sa/dp/B0DLG3S62C?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/sa/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [SAR 40.90 at Amazon](https://www.amazon.sa/dp/B09C1B7BH5?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### Simple

- [Micellar Water](https://lovi.care/skincare/sa/p/simple/micellar-water/for/mature-skin) — Average fit — [SAR 68.45 at Amazon](https://www.amazon.sa/dp/B00X3OQ6N0?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Micellar Cleansing Water](https://lovi.care/skincare/sa/p/simple/micellar-cleansing-water/for/sensitive-skin) — High fit — [SAR 68.45 at Amazon](https://www.amazon.sa/dp/B00X3OQ6N0?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Hydrating Light Moisturiser](https://lovi.care/skincare/sa/p/simple/hydrating-light-moisturiser/for/dry-skin) — Average fit — [SAR 28.99 at Amazon](https://www.amazon.sa/dp/B000LQX6XG?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Refreshing Facial Wash](https://lovi.care/skincare/sa/p/simple/refreshing-facial-wash/for/acne-prone-skin) — Average fit — [SAR 24.99 at Amazon](https://www.amazon.sa/dp/B000LQUA6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Replenishing Rich Moisturiser](https://lovi.care/skincare/sa/p/simple/replenishing-rich-moisturiser/for/dry-skin) — Average fit — [SAR 63.00 at Amazon](https://www.amazon.sa/dp/B000LNHB6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Water Boost Hydrating Gel Cream](https://lovi.care/skincare/sa/p/simple/water-boost-hydrating-gel-cream/for/dry-skin) — Average fit — [SAR 78.18 at Amazon](https://www.amazon.sa/dp/B0C3Z57B1M?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Kind to Skin Soothing Facial Toner](https://lovi.care/skincare/sa/p/simple/kind-to-skin-soothing-facial-toner/for/mature-skin) — Superior fit — [SAR 29.99 at Amazon](https://www.amazon.sa/dp/B076V2D94Y?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## People Say

Medicube

Simple

- Soothing and Gentle Formulas Often Mentioned Mostly Mentioned “Does not cause any form of irritation on the skin which I love. — Simple Micellar Cleansing Water” “The only cleanser that doesn't turn my face red. — Simple Micellar Water” “no artificial perfume — Simple Hydrating Light Moisturiser” “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask”
- Hydration and Moisture Mostly Mentioned Mostly Mentioned “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum” “glass skin — Medicube PDRN Pink Collagen Gel Mask” “banished dryness within days — Simple Replenishing Rich Moisturiser” “Instantly boosts skin's hydration... face doesn't feel dry and tight. — Simple Micellar Cleansing Water”
- Affordable Value Not noted Often Mentioned “great value for money — Simple Kind to Skin Soothing Facial Toner” “super affordable — Simple Hydrating Light Moisturiser” “Can't beat the price for the quality. — Simple Micellar Water”
- Packaging and Conveniences Often Mentioned Rarely Noted “tweezers included are hygienic — Medicube Zero Pore Pad” “perfect slip for my device — Medicube Collagen Jelly Cream” “keeps my skincare in place — Medicube Collagen Night Wrapping Mask” “No need to rinse... perfect for traveling or lazy nights. — Simple Micellar Cleansing Water”
- Lightweight and Non-Greasy Not noted Often Mentioned “sinks in instantly — Simple Water Boost Hydrating Gel Cream” “absorbs very quickly — Simple Hydrating Light Moisturiser” “absorbs really well — Simple Replenishing Rich Moisturiser”
- Glow and Radiance Often Mentioned Not noted “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “Dark spots go away faster — Medicube Deep Vita C Pad”
- Sticky or Heavy Residue Often Mentioned Sometimes Noted “Feels slimy on skin — Simple Refreshing Facial Wash” “Still feeling a little bit of a film on my skin. — Simple Micellar Cleansing Water” “leaves a tacky film — Simple Kind to Skin Soothing Facial Toner” “hair sticks to my face — Medicube Collagen Jelly Cream”
- Breakouts and Skin Irritation Often Mentioned Sometimes Noted “caused redness and sensitivity — Medicube Zero Pore Pad” “woke up with whiteheads — Medicube Collagen Night Wrapping Mask” “Gave me tiny bumps on my forehead. — Simple Micellar Water” “caused major breakouts — Simple Hydrating Light Moisturiser”
- Drying and Stripping Effects Sometimes Noted Sometimes Noted “Skin feels very tight — Medicube Zero Foam Cleanser” “skin felt very tight — Medicube Zero Pore Blackhead Mud Mask” “not moisturizing enough — Simple Hydrating Light Moisturiser” “skin felt tight after an hour — Simple Water Boost Hydrating Gel Cream”

### Medicube vs Simple routines for dry skin

#### Medicube-focused routine

- Cleanser: [Zero Foam Cleanser](https://lovi.care/skincare/sa/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [SAR 40.90 at Amazon](https://www.amazon.sa/dp/B09C1B7BH5?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/sa/p/medicube/triple-collagen-toner/for/dry-skin) — High fit — [SAR 50.00 at Amazon](https://www.amazon.sa/dp/B085VS2J3T?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/sa/p/medicube/age-r-booster-gel/for/dry-skin) — Superior fit — [SAR 117.99 at Amazon](https://www.amazon.sa/dp/B0H4MHPRLG?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/sa/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — [SAR 75.00 at Amazon](https://www.amazon.sa/dp/B09D7QJP1M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/sa/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [SAR 65.11 at Amazon](https://www.amazon.sa/dp/B084Q16G8D?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/sa/p/medicube/zero-pore-pad/for/dry-skin) — Average fit — [SAR 64.80 at Amazon](https://www.amazon.sa/dp/B0CVRCR6VF?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [One Day Exosome Shot 2000](https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/dry-skin) — High fit — [SAR 34.00 at Amazon](https://www.amazon.sa/dp/B0D16L5F2M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [FANCL Facial Washing Powder](https://lovi.care/skincare/sa/p/fancl/facial-washing-powder/for/dry-skin) — High fit — [SAR 130.30 at Amazon](https://www.amazon.sa/dp/B01KTJXVI4?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Nourishing Mask: [Deep Peptide Radiance Mask](https://lovi.care/skincare/sa/p/medicube/deep-peptide-radiance-mask/for/dry-skin) — High fit — [SAR 120.88 at Amazon](https://www.amazon.sa/dp/B0HGBQSTDY?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

#### Simple-focused routine

- Cleanser: [Refreshing Facial Wash](https://lovi.care/skincare/sa/p/simple/refreshing-facial-wash/for/dry-skin) — Low fit — [SAR 24.99 at Amazon](https://www.amazon.sa/dp/B000LQUA6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Moisturizer: [Replenishing Rich Moisturiser](https://lovi.care/skincare/sa/p/simple/replenishing-rich-moisturiser/for/dry-skin) — Average fit — [SAR 63.00 at Amazon](https://www.amazon.sa/dp/B000LNHB6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/sa/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — [SAR 75.00 at Amazon](https://www.amazon.sa/dp/B09D7QJP1M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Micellar Cleansing Water](https://lovi.care/skincare/sa/p/simple/micellar-cleansing-water/for/dry-skin) — High fit — [SAR 68.45 at Amazon](https://www.amazon.sa/dp/B00X3OQ6N0?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [ROUND LAB 1025 Dokdo Cleansing Water](https://lovi.care/skincare/sa/p/round-lab/1025-dokdo-cleansing-water/for/dry-skin) — Superior fit — [SAR 72.64 at Amazon](https://www.amazon.sa/dp/B0F625GKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sa/p/peach-and-lily/glass-skin-refining-serum/for/dry-skin) — Superior fit — [SAR 222.00 at Amazon](https://www.amazon.sa/dp/B08H4QPM19?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [FANCL Facial Washing Powder](https://lovi.care/skincare/sa/p/fancl/facial-washing-powder/for/dry-skin) — High fit — [SAR 130.30 at Amazon](https://www.amazon.sa/dp/B01KTJXVI4?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Nourishing Mask: [Mediheal Watermide Essential Mask](https://lovi.care/skincare/sa/p/mediheal/watermide-essential-mask/for/dry-skin) — Superior fit — [SAR 234.73 at Amazon](https://www.amazon.sa/dp/B0FMFZRJTD?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · SAR 698.98 · 86% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B09C1B7BH5&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B09D7QJP1M&Quantity.4=1&ASIN.5=B084Q16G8D&Quantity.5=1&ASIN.6=B0CVRCR6VF&Quantity.6=1&ASIN.7=B0D16L5F2M&Quantity.7=1&ASIN.8=B01KTJXVI4&Quantity.8=1&ASIN.9=B0HGBQSTDY&Quantity.9=1&AssociateTag=lovisa02-21) [Buy Simple routine · SAR 891.11 · 83% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B000LQUA6M&Quantity.1=1&ASIN.2=B000LNHB6M&Quantity.2=1&ASIN.3=B09D7QJP1M&Quantity.3=1&ASIN.4=B00X3OQ6N0&Quantity.4=1&ASIN.5=B0F625GKWW&Quantity.5=1&ASIN.6=B08H4QPM19&Quantity.6=1&ASIN.7=B01KTJXVI4&Quantity.7=1&ASIN.8=B0FMFZRJTD&Quantity.8=1&AssociateTag=lovisa02-21) [See multi-brand routine · 96% fit](https://lovi.care/skincare/sa/skin/dry-skin)

### Medicube vs Simple routines for oily skin

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/sa/p/medicube/red-foam-cleanser/for/oily-skin) — High fit — [SAR 35.61 at Amazon](https://www.amazon.sa/dp/B073ZBXSJD?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/sa/p/medicube/triple-collagen-toner/for/oily-skin) — High fit — [SAR 50.00 at Amazon](https://www.amazon.sa/dp/B085VS2J3T?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/sa/p/medicube/age-r-booster-gel/for/oily-skin) — High fit — [SAR 117.99 at Amazon](https://www.amazon.sa/dp/B0H4MHPRLG?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/sa/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [SAR 46.95 at Amazon](https://www.amazon.sa/dp/B07C5VGNLY?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/sa/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [SAR 245.95 at Amazon](https://www.amazon.sa/dp/B0DNJKPSB8?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/sa/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [SAR 64.80 at Amazon](https://www.amazon.sa/dp/B0CVRCR6VF?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/sa/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [SAR 157.51 at Amazon](https://www.amazon.sa/dp/B001VMJSCW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/sa/p/medicube/zero-pore-blackhead-mud-mask/for/oily-skin) — Average fit — [SAR 87.59 at Amazon](https://www.amazon.sa/dp/B0H6GFKP6V?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

#### Simple-focused routine

- Cleanser: [Refreshing Facial Wash](https://lovi.care/skincare/sa/p/simple/refreshing-facial-wash/for/oily-skin) — Average fit — [SAR 24.99 at Amazon](https://www.amazon.sa/dp/B000LQUA6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Some By Mi Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/sa/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — [SAR 53.04 at Amazon](https://www.amazon.sa/dp/B08125WDCF?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Replenishing Rich Moisturiser](https://lovi.care/skincare/sa/p/simple/replenishing-rich-moisturiser/for/oily-skin) — Average fit — [SAR 63.00 at Amazon](https://www.amazon.sa/dp/B000LNHB6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/sa/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [SAR 46.95 at Amazon](https://www.amazon.sa/dp/B07C5VGNLY?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Micellar Cleansing Water](https://lovi.care/skincare/sa/p/simple/micellar-cleansing-water/for/oily-skin) — High fit — [SAR 68.45 at Amazon](https://www.amazon.sa/dp/B00X3OQ6N0?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Caudalie Vinopure Purifying Toner](https://lovi.care/skincare/sa/p/caudalie/vinopure-purifying-toner/for/oily-skin) — Superior fit — [SAR 187.00 at Amazon](https://www.amazon.sa/dp/B0GFGP11BW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sa/p/peach-and-lily/glass-skin-refining-serum/for/oily-skin) — Superior fit — [SAR 222.00 at Amazon](https://www.amazon.sa/dp/B08H4QPM19?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/sa/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [SAR 157.51 at Amazon](https://www.amazon.sa/dp/B001VMJSCW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Goldfaden MD Facial Detox Mask](https://lovi.care/skincare/sa/p/goldfaden-md/facial-detox-mask/for/oily-skin) — Superior fit — [SAR 328.29 at Amazon](https://www.amazon.sa/dp/B06Y8R9VGG?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · SAR 806.40 · 88% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B07C5VGNLY&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B0CVRCR6VF&Quantity.6=1&ASIN.7=B001VMJSCW&Quantity.7=1&ASIN.8=B0H6GFKP6V&Quantity.8=1&AssociateTag=lovisa02-21) [Buy Simple routine · SAR 1,151.23 · 88% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B000LQUA6M&Quantity.1=1&ASIN.2=B08125WDCF&Quantity.2=1&ASIN.3=B000LNHB6M&Quantity.3=1&ASIN.4=B07C5VGNLY&Quantity.4=1&ASIN.5=B00X3OQ6N0&Quantity.5=1&ASIN.6=B0GFGP11BW&Quantity.6=1&ASIN.7=B08H4QPM19&Quantity.7=1&ASIN.8=B001VMJSCW&Quantity.8=1&ASIN.9=B06Y8R9VGG&Quantity.9=1&AssociateTag=lovisa02-21) [See multi-brand routine · 97% fit](https://lovi.care/skincare/sa/skin/oily-skin)

### Medicube vs Simple routines for combination skin

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/sa/p/medicube/red-foam-cleanser/for/combination-skin) — High fit — [SAR 35.61 at Amazon](https://www.amazon.sa/dp/B073ZBXSJD?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/sa/p/medicube/triple-collagen-toner/for/combination-skin) — High fit — [SAR 50.00 at Amazon](https://www.amazon.sa/dp/B085VS2J3T?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/sa/p/medicube/age-r-booster-gel/for/combination-skin) — High fit — [SAR 117.99 at Amazon](https://www.amazon.sa/dp/B0H4MHPRLG?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/sa/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — [SAR 46.95 at Amazon](https://www.amazon.sa/dp/B07C5VGNLY?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/sa/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [SAR 245.95 at Amazon](https://www.amazon.sa/dp/B0DNJKPSB8?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/sa/p/medicube/zero-pore-pad/for/combination-skin) — Superior fit — [SAR 64.80 at Amazon](https://www.amazon.sa/dp/B0CVRCR6VF?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/sa/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [SAR 157.51 at Amazon](https://www.amazon.sa/dp/B001VMJSCW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/sa/p/medicube/zero-pore-blackhead-mud-mask/for/combination-skin) — Average fit — [SAR 87.59 at Amazon](https://www.amazon.sa/dp/B0H6GFKP6V?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

#### Simple-focused routine

- Cleanser: [Refreshing Facial Wash](https://lovi.care/skincare/sa/p/simple/refreshing-facial-wash/for/combination-skin) — Average fit — [SAR 24.99 at Amazon](https://www.amazon.sa/dp/B000LQUA6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/sa/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [SAR 166.90 at Amazon](https://www.amazon.sa/dp/B008EPPIQ4?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Replenishing Rich Moisturiser](https://lovi.care/skincare/sa/p/simple/replenishing-rich-moisturiser/for/combination-skin) — Average fit — [SAR 63.00 at Amazon](https://www.amazon.sa/dp/B000LNHB6M?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/sa/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — [SAR 46.95 at Amazon](https://www.amazon.sa/dp/B07C5VGNLY?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Micellar Cleansing Water](https://lovi.care/skincare/sa/p/simple/micellar-cleansing-water/for/combination-skin) — Average fit — [SAR 68.45 at Amazon](https://www.amazon.sa/dp/B00X3OQ6N0?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/sa/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [SAR 64.80 at Amazon](https://www.amazon.sa/dp/B0CVRCR6VF?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/sa/p/peach-and-lily/glass-skin-refining-serum/for/combination-skin) — Superior fit — [SAR 222.00 at Amazon](https://www.amazon.sa/dp/B08H4QPM19?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/sa/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [SAR 157.51 at Amazon](https://www.amazon.sa/dp/B001VMJSCW?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [KORA Organics Turmeric Brightening & Exfoliating Mask](https://lovi.care/skincare/sa/p/kora-organics/turmeric-brightening-and-exfoliating-mask/for/combination-skin) — Superior fit — [SAR 168.77 at Amazon](https://www.amazon.sa/dp/B09G7PCTTG?tag=lovisa02-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · SAR 806.40 · 88% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B085VS2J3T&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B07C5VGNLY&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B0CVRCR6VF&Quantity.6=1&ASIN.7=B001VMJSCW&Quantity.7=1&ASIN.8=B0H6GFKP6V&Quantity.8=1&AssociateTag=lovisa02-21) [Buy Simple routine · SAR 983.37 · 87% fit](https://www.amazon.sa/gp/aws/cart/add.html?ASIN.1=B000LQUA6M&Quantity.1=1&ASIN.2=B008EPPIQ4&Quantity.2=1&ASIN.3=B000LNHB6M&Quantity.3=1&ASIN.4=B07C5VGNLY&Quantity.4=1&ASIN.5=B00X3OQ6N0&Quantity.5=1&ASIN.6=B0CVRCR6VF&Quantity.6=1&ASIN.7=B08H4QPM19&Quantity.7=1&ASIN.8=B001VMJSCW&Quantity.8=1&ASIN.9=B09G7PCTTG&Quantity.9=1&AssociateTag=lovisa02-21) [See multi-brand routine · 97% fit](https://lovi.care/skincare/sa/skin/combination-skin)

## Questions and answers

### Medicube or Simple: which is better?

Both Medicube and Simple offer great skincare options, with Medicube standing out for glow and radiance while Simple provides lightweight, budget-friendly moisturizers and gentle makeup removers. Ingredients like [niacinamide](https://lovi.care/skincare/sa/ingredients/niacinamide) help reduce pigmentation, and topical [hyaluronic acid](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid) supports skin quality and hydration.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Medicube and Simple?

Medicube is a South Korean brand owned by APR Corp. that focuses on radiant glow and packaging conveniences, whereas Simple is a British brand founded in 1960 and owned by Unilever PLC that is known for being budget-friendly and offering lightweight, gentle, and non-greasy formulas. Both brands feature products that contain niacinamide.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Simple for dry skin?

Both Medicube and Simple offer a High routine fit for dry skin. Medicube features deep hydration moisturizers and hydrating ingredients like hyaluronic acid, which helps improve skin quality.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Simple: which cleanser is better?

Medicube is generally better for cleansers on the products on this page, as its Zero Foam Cleanser and Red Foam Cleanser fit a wider range of skin types with higher ratings than Simple, whose Refreshing Facial Wash has low fit levels for dry and dry sensitive skin. Both brands offer fragrance-free cleansing options, but Medicube incorporates key ingredients like [salicylic acid](https://lovi.care/skincare/sa/ingredients/salicylic-acid) and [centella asiatica](https://lovi.care/skincare/sa/ingredients/centella-asiatica) to target concerns like acne and excess oil.

### Which is more affordable, Medicube or Simple?

Simple is more affordable, offering value-friendly moisturizers and budget makeup removers compared to Medicube.

### Medicube or Simple: which brand offers better glow and radiance?

Medicube does better than Simple for glow and radiance. The products on this page help deliver a radiant glow.

### Medicube or Simple: which products are free of fragrance?

Medicube offers 23 out of 25 products on its page without fragrance, while Simple features no fragrance across every single product listed on its page.

### Medicube or Simple: which brand has better packaging and conveniences?

Medicube does better than Simple for packaging and conveniences among the products on this page.

### Medicube or Simple for oily skin?

Both Medicube and Simple have a High routine fit level for oily skin. Medicube fits oily skin best through its brand-focused routines, while Simple is known for offering lightweight, value-friendly moisturizers.

### Medicube or Simple: which moisturizer is better?

Both Medicube and Simple offer effective moisturizers, with Medicube standing out for its glow and radiance benefits while Simple is recognized for its lightweight and value-friendly formulas. Key ingredients like niacinamide and hyaluronic acid found across their products help support skin hydration.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Simple for sensitive skin?

Both Medicube and Simple show a High routine fit for sensitive skin. Simple does better for soothing and gentle formulas, while Medicube offers an advantage for glow and radiance.

### Medicube or Simple for acne-prone skin?

Both Medicube and Simple provide an equal High routine fit for acne-prone skin. Medicube offers dedicated targeted treatments featuring niacinamide and salicylic acid across the products on this page.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate vitamin e, Tocopheryl acetate · Urologia Internationalis, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol, Panthenol vitamin b5, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel leaf water · Phytochemistry, 2001
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment](https://pubmed.ncbi.nlm.nih.gov/19134126/) Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers](https://pubmed.ncbi.nlm.nih.gov/27756097/) Sodium ascorbyl phosphate · Drug Research, 2017
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel leaf water · Journal of Cosmetic Science, 2018
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis](https://pubmed.ncbi.nlm.nih.gov/33128473/) Borago officinalis seed oil · Lipids, 2020
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects](https://pubmed.ncbi.nlm.nih.gov/22142309/) Sodium ascorbyl phosphate · Experimental Dermatology, 2012
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e, Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study](https://pubmed.ncbi.nlm.nih.gov/41211697/) Saccharide isomerate · The Journal of Dermatological Treatment, 2025
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Saccharide isomerate · Lasers in Medical Science, 2025
- [Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population](https://pubmed.ncbi.nlm.nih.gov/35279940/) Saccharide isomerate · Journal of Cosmetic Dermatology, 2023

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/sa/brands/medicube)
- British skincare: [Simple](https://lovi.care/skincare/sa/brands/simple)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/sa/compare/skin1004-vs-medicube)
- [SKIN1004 vs Simple](https://lovi.care/skincare/sa/compare/skin1004-vs-simple)
- [Anua vs Medicube](https://lovi.care/skincare/sa/compare/anua-vs-medicube)
- [Anua vs Simple](https://lovi.care/skincare/sa/compare/anua-vs-simple)
- [Medicube vs The Ordinary](https://lovi.care/skincare/sa/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/sa/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/sa/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/sa/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/sa/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/sa/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/sa/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/sa/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/sa/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/sa/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/sa/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/sa/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/sa/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/sa/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/sa/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/sa/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-simple
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-simple
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-simple
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-simple
- France: https://lovi.care/skincare/fr/compare/medicube-vs-simple
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-simple
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-simple
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-simple
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-simple
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-simple
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-simple
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-simple (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-simple