# Good Molecules vs Sesderma

Page: https://lovi.care/skincare/sa/compare/good-molecules-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Good Molecules and Sesderma are distinguished skincare brands that offer thoughtful [serums](https://lovi.care/skincare/sa/ingredients/serum), moisturizers, eye products, and exfoliants featuring key ingredients like [glycerin](https://lovi.care/skincare/sa/ingredients/glycerin) and [hyaluronic acid](https://lovi.care/skincare/sa/ingredients/hyaluronic-acid) alongside advanced botanical [extracts](https://lovi.care/skincare/sa/ingredients/extract). The American line suits sensitive and acne-prone skin best, while the Spanish counterpart caters well to sensitive, hyperpigmented, and aging skin types. Both deliver notable benefits through meticulously engineered formulas, though the first focuses on restoring barrier function and hydration while the second emphasizes refining texture and promoting radiance.

Good Molecules is an American skincare brand founded in 2019 and owned by Beautylish, Inc..

[beautymatter.com](https://beautymatter.com/articles/aria-growth-partners-makes-investment-in-good-molecules) [goodmolecules.com](https://www.goodmolecules.com/about) [pitchbook.com](https://pitchbook.com/profiles/company/458272-45) [preqin.com](https://www.preqin.com/data/profile/asset/good-molecules--llc-/802471)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Good Molecules and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg639f3d2388).

### Popular Good Molecules vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [SAR 152.67 at Amazon](https://www.amazon.sa/dp/B00987RKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### Good Molecules

- [Discoloration Correcting Serum](https://lovi.care/skincare/sa/p/good-molecules/discoloration-correcting-serum/for/dry-skin) — High fit — [SAR 191.00 at Amazon](https://www.amazon.sa/dp/B0BX32CXP6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Acid Serum](https://lovi.care/skincare/sa/p/good-molecules/hyaluronic-acid-serum/for/dry-skin) — Superior fit — [SAR 78.00 at Amazon](https://www.amazon.sa/dp/B08TM8DLFJ?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Gentle Retinol Cream](https://lovi.care/skincare/sa/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit
- [Niacinamide Serum](https://lovi.care/skincare/sa/p/good-molecules/niacinamide-serum/for/oily-skin) — Average fit — [SAR 85.12 at Amazon](https://www.amazon.sa/dp/B08R994Q1L?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Niacinamide Brightening Toner](https://lovi.care/skincare/sa/p/good-molecules/niacinamide-brightening-toner/for/dry-skin) — High fit — [SAR 99.96 at Amazon](https://www.amazon.sa/dp/B08C2BLPD2?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [PIMPLE PATCHES](https://lovi.care/skincare/sa/p/good-molecules/pimple-patches/for/acne-prone-skin) — Average fit
- [Yerba Mate Wake Up Eye Gel](https://lovi.care/skincare/sa/p/good-molecules/yerba-mate-wake-up-eye-gel/for/mature-skin) — Superior fit — [SAR 71.78 at Amazon](https://www.amazon.sa/dp/B091NJQ29P?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Lightweight Daily Moisturizer](https://lovi.care/skincare/sa/p/good-molecules/lightweight-daily-moisturizer/for/dry-skin) — Superior fit — [SAR 114.00 at Amazon](https://www.amazon.sa/dp/B0C26KZ7G6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

### Good Molecules vs Sesderma [serums](https://lovi.care/skincare/sa/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [SAR 152.67 at Amazon](https://www.amazon.sa/dp/B00987RKWW?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### Good Molecules

- [Discoloration Correcting Serum](https://lovi.care/skincare/sa/p/good-molecules/discoloration-correcting-serum/for/dry-skin) — High fit — [SAR 191.00 at Amazon](https://www.amazon.sa/dp/B0BX32CXP6?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Gentle Retinol Cream](https://lovi.care/skincare/sa/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit
- [Niacinamide Serum](https://lovi.care/skincare/sa/p/good-molecules/niacinamide-serum/for/oily-skin) — Average fit — [SAR 85.12 at Amazon](https://www.amazon.sa/dp/B08R994Q1L?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [PIMPLE PATCHES](https://lovi.care/skincare/sa/p/good-molecules/pimple-patches/for/acne-prone-skin) — Average fit
- [Super Peptide Serum](https://lovi.care/skincare/sa/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [SAR 113.86 at Amazon](https://www.amazon.sa/dp/B091MTKS35?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Overnight Exfoliating Treatment](https://lovi.care/skincare/sa/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [SAR 77.61 at Amazon](https://www.amazon.sa/dp/B08TMDRF1L?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Mandelic Acid Serum](https://lovi.care/skincare/sa/p/good-molecules/mandelic-acid-serum/for/dry-sensitive-skin) — Superior fit — [SAR 101.74 at Amazon](https://www.amazon.sa/dp/B0D6TWLB6T?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Daily Brightening Serum](https://lovi.care/skincare/sa/p/good-molecules/daily-brightening-serum/for/dry-skin) — High fit — [SAR 29.44 at Amazon](https://www.amazon.sa/dp/B091MGP94B?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Vitamin C Booster Powder](https://lovi.care/skincare/sa/p/good-molecules/vitamin-c-booster-powder/for/mature-skin) — High fit

## Questions and answers

### Good Molecules or Sesderma: which is better?

Good Molecules is the better choice for shoppers looking for a wider variety of options, as the products on this page cover multiple skincare categories with no fragrance listed across the entire range, whereas Sesderma only features a single [serum](https://lovi.care/skincare/sa/ingredients/serum) that contains fragrance.

### What is the difference between Good Molecules and Sesderma?

Good Molecules offers a much wider range of products on this page compared to Sesderma, and every Good Molecules product lists no fragrance. In addition, Good Molecules fits sensitive skin, acne-prone skin, and dry sensitive skin best.

### Which is more affordable, Good Molecules or Sesderma?

Good Molecules is more affordable, offering budget-friendly serums that reviewers frequently praise for great value.

### Which causes fewer breakouts, Good Molecules or Sesderma?

Good Molecules has multiple acne-prone skin options on this page, whereas Sesderma lists only one serum that has a High fit level for acne-prone skin. Reviewers note that Good Molecules sometimes causes breakouts.

### How do the founding years and countries of origin compare between Good Molecules and Sesderma?

Good Molecules was founded in 2019 in the United States, whereas Sesderma was founded earlier in 1989 in Spain.

### Which brand has more fragrance-free options among their listed products, Good Molecules or Sesderma?

Good Molecules has more fragrance-free options because every product on its page lists no fragrance, whereas the single Sesderma product on this page includes fragrance.

### What is the Lovi fit level of Sesderma's Azelac RU Serum for dry skin compared to Good Molecules serums?

Sesderma's Azelac RU Serum has a Low Lovi fit level for dry skin, whereas Good Molecules serums range from Average to High or Superior for dry skin.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid, Ascorbic acid powder · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts](https://pubmed.ncbi.nlm.nih.gov/34552134/) Ilex paraguariensis leaf extract · Scientific Reports, 2021
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Anti-acne vulgaris effects of chlorogenic acid by anti-inflammatory activity and lipogenesis inhibition](https://pubmed.ncbi.nlm.nih.gov/33433016/) Ilex paraguariensis leaf extract · Experimental Dermatology, 2021
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid, Ascorbic acid powder · Journal of Cosmetic Dermatology, 2020
- [A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations](https://pubmed.ncbi.nlm.nih.gov/26119285/) Arbutin · Journal of Cosmetic Dermatology, 2015
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract · Experimental Dermatology, 2015
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine](https://pubmed.ncbi.nlm.nih.gov/17348991/) Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula](https://pubmed.ncbi.nlm.nih.gov/34198790/) Saccharomyces ferment filtrate · Journal of Clinical Medicine, 2021
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil](https://pubmed.ncbi.nlm.nih.gov/31957954/) Avocado oil · Journal of Cosmetic Dermatology, 2020
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry](https://pubmed.ncbi.nlm.nih.gov/38831914/) Ilex paraguariensis extract · Frontiers in Chemistry, 2024
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study](https://pubmed.ncbi.nlm.nih.gov/33022197/) Arbutin · Journal of Cosmetic Science, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract, Camellia sinensis leaf water · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- ['All-natural' anti-wrinkle emulsion serum with Acmella oleracea extract: A design of experiments (DoE) formulation approach, rheology and in vivo skin performance/efficacy evaluation](https://pubmed.ncbi.nlm.nih.gov/34297422/) Acmella oleracea extract · International Journal of Cosmetic Science, 2021
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun-damaged skin](https://pubmed.ncbi.nlm.nih.gov/32588531/) Cetyl tranexamate mesylate · Journal of Cosmetic Dermatology, 2021
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation](https://pubmed.ncbi.nlm.nih.gov/37183632/) Arbutin · Biomaterials Science, 2023
- [Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres](https://pubmed.ncbi.nlm.nih.gov/25876142/) Papain · Giornale Italiano Di Dermatologia E Venereologia, 2015
- [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer](https://pubmed.ncbi.nlm.nih.gov/35456214/) Saccharomyces ferment filtrate · Journal of Clinical Medicine, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes](https://pubmed.ncbi.nlm.nih.gov/39778604/) 3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties](https://pubmed.ncbi.nlm.nih.gov/39617635/) Acmella oleracea extract · International Journal of Cosmetic Science, 2025
- [Taurine and Polyphenol Complex Repaired Epidermal Keratinocyte Wounds by Regulating IL8 and TIMP2 Expression](https://pubmed.ncbi.nlm.nih.gov/39194729/) Ilex paraguariensis leaf extract · Current Issues in Molecular Biology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects](https://pubmed.ncbi.nlm.nih.gov/25362595/) Hippophae rhamnoides oil · Pakistan Journal of Pharmaceutical Sciences, 2014
- [Development and efficacy assessments of tea seed oil makeup remover](https://pubmed.ncbi.nlm.nih.gov/27988044/) Camellia oleifera seed oil · Annales Pharmaceutiques Francaises, 2017
- [Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics](https://pubmed.ncbi.nlm.nih.gov/40391588/) Camellia sinensis leaf water · International Journal of Cosmetic Science, 2025
- [Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41319188/) Camellia oleifera seed oil · International Journal of Cosmetic Science, 2026
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color](https://pubmed.ncbi.nlm.nih.gov/33938432/) Saccharomyces ferment filtrate · Skinmed, 2021
- [Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/37194909/) Camellia sinensis leaf water · Journal of Cosmetic Dermatology, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025

## The brands

- American skincare: [Good Molecules](https://lovi.care/skincare/sa/brands/good-molecules)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/sa/brands/sesderma)

## More comparisons

- [SKIN1004 vs Good Molecules](https://lovi.care/skincare/sa/compare/skin1004-vs-good-molecules)
- [SKIN1004 vs Sesderma](https://lovi.care/skincare/sa/compare/skin1004-vs-sesderma)
- [Anua vs Good Molecules](https://lovi.care/skincare/sa/compare/anua-vs-good-molecules)
- [Anua vs Sesderma](https://lovi.care/skincare/sa/compare/anua-vs-sesderma)
- [Medicube vs Good Molecules](https://lovi.care/skincare/sa/compare/medicube-vs-good-molecules)
- [Medicube vs Sesderma](https://lovi.care/skincare/sa/compare/medicube-vs-sesderma)
- [The Ordinary vs Good Molecules](https://lovi.care/skincare/sa/compare/the-ordinary-vs-good-molecules)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/sa/compare/the-ordinary-vs-sesderma)
- [Beauty of Joseon vs Good Molecules](https://lovi.care/skincare/sa/compare/beauty-of-joseon-vs-good-molecules)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/sa/compare/beauty-of-joseon-vs-sesderma)
- [COSRX vs Good Molecules](https://lovi.care/skincare/sa/compare/cosrx-vs-good-molecules)
- [COSRX vs Sesderma](https://lovi.care/skincare/sa/compare/cosrx-vs-sesderma)
- [CeraVe vs Good Molecules](https://lovi.care/skincare/sa/compare/cerave-vs-good-molecules)
- [CeraVe vs Sesderma](https://lovi.care/skincare/sa/compare/cerave-vs-sesderma)
- [La Roche-Posay vs Good Molecules](https://lovi.care/skincare/sa/compare/la-roche-posay-vs-good-molecules)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/sa/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs Good Molecules](https://lovi.care/skincare/sa/compare/dr-althea-vs-good-molecules)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/sa/compare/dr-althea-vs-sesderma)
- [Some By Mi vs Good Molecules](https://lovi.care/skincare/sa/compare/some-by-mi-vs-good-molecules)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/sa/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/good-molecules-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/good-molecules-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/good-molecules-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/good-molecules-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/good-molecules-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/good-molecules-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/good-molecules-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/good-molecules-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/good-molecules-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/good-molecules-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/good-molecules-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/good-molecules-vs-sesderma (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/compare/good-molecules-vs-sesderma