Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage
Chrysin · Journal of Agricultural and Food Chemistry, 2011Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomile extract · International Journal of Molecular Medicine, 2016Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation
Papain · The Journal of Investigative Dermatology, 2015Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf powder · Clinical Pharmacology, 2018The topical effect of grape seed extract 2% cream on surgery wound healing
Palmitoyl grape seed extract · Global Journal of Health Science, 2014Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Vitis vinifera juice grape juice, Resveratrol, Grape extract · Molecules, 2023Role of Resveratrol in Regulating Cutaneous Functions
Vitis vinifera juice grape juice · Evidence-based Complementary and Alternative Medicine, 2020α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Resveratrol as a factor preventing skin aging and affecting its regeneration
Vitis vinifera juice grape juice · Postepy Dermatologii I Alergologii, 2022Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
Oleanolic acid · Biomolecules & Therapeutics, 2021Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging
Bentonite · Carbohydrate Polymers, 2017Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Oleanolic acid · Nanoscale Research Letters, 2020Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins
Vinolevure · Food and Chemical Toxicology, 2008Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Palmitoyl grape seed extract, Grape seed oil · International Journal of Cosmetic Science, 2015Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid · Journal of Cosmetic Dermatology, 2019A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation
Parfum · Pharmaceuticals, 2023Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility
Enantia chlorantha bark extract · International Journal of Biological Macromolecules, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function
Rosmarinus officinalis oil leaf rosemary oil leaf · International Journal of Molecular Sciences, 2022Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin
Terminalia arjuna extract · Skin Pharmacology and Physiology, 2014A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid · Journal of Cosmetic Dermatology, 2021Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes
Oleanolic acid · Antioxidants, 2021Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin
Butylene glycol · Journal of Cosmetic Dermatology, 2019Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging
Grape seed oil · Pakistan Journal of Pharmaceutical Sciences, 2021Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rosa damascena oil flower · Acta Pharmaceutica, 2013Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Papain · Giornale Italiano Di Dermatologia E Venereologia, 2015Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Vinolevure · Journal of Clinical Medicine, 2023Dyspigmentation, skin physiology, and a novel approach to skin lightening
Vinolevure · Journal of Cosmetic Dermatology, 2013Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract
Palmitoyl grape seed extract · Journal of Cosmetic Dermatology, 2022Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study
Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Grape seed oil · Skin Pharmacology and Physiology, 2007Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Genotoxicity of micro- and nano-particles of kaolin in human primary dermal keratinocytes and fibroblasts
Purifying clay · Genes and Environment, 2020Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Citric acid · Journal of Drugs in Dermatology, 2013Dirt-binding particles consisting of hydrogenated castor oil beads constitute a nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination in a three-step programme of occupational skin protection
Castor oil · The British Journal of Dermatology, 2010Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin
Melissa officinalis oil · Photodermatology, Photoimmunology & Photomedicine, 2025A method for maintaining the clinical results of 4% hydroquinone and 0.025% tretinoin with a cosmeceutical formulation
Vinolevure · Journal of Drugs in Dermatology, 2015Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021The effect of different formulations of equivalent active ingredients on the performance of two topical wound treatment products
Castor oil · Ostomy/wound Management, 2004The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
Bentonite · Journal of Cosmetic Dermatology, 2025Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter extract shea butter extract, Shea butter extract, Saccharide isomerate · Lasers in Medical Science, 2025Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023The harnessing potential of carboxymethyl beta glucan: A driver of skin repair
Sodium carboxymethyl betaglucan · International Journal of Cosmetic Science, 2026
