# Bayer vs Natura Bissé

Page: https://lovi.care/skincare/sa/compare/bayer-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Bayer is a German skincare brand founded in 1863 and owned by Bayer AG.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Bayer) [de.wikipedia.org](https://de.wikipedia.org/wiki/Bayer_AG) [forbes.com](https://www.forbes.com/companies/bayer/) [prnewswire.com](https://www.prnewswire.com/news-releases/wellspring-consumer-healthcare-acquires-iconic-otc-skin-care-brands-from-bayer-301789173.html)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Bayer and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgcf3f8f8a77).

### Popular Bayer vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/sa/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [SAR 1,034.77 at Amazon](https://www.amazon.sa/dp/B0BKLRMKZV?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

#### Bayer

- [Skinoren Cream 20%](https://lovi.care/skincare/sa/p/bayer/skinoren-cream-20/for/oily-skin) — High fit

## Questions and answers

### Bayer or Natura Bissé: which is better?

Bayer is better for oily and acne-prone skin, where Lovi rates its products High, while Natura Bissé is better for mature skin with a Superior fit. Every product on this page from Bayer lists no fragrance, whereas the Natura Bissé moisturizer on this page includes fragrance.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Bayer and Natura Bissé?

Bayer fits oily and acne-prone skin with a High rating, whereas Natura Bissé fits mature skin with a Superior rating. Every product on the Bayer page lists no fragrance, while the Natura Bissé moisturizer on this page contains fragrance.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which is more affordable, Bayer or Natura Bissé?

Neither brand is more affordable on this page because the page facts do not provide pricing information for Bayer or Natura Bissé.

### Which brand uses fragrance in its products, Bayer or Natura Bissé?

Natura Bissé uses fragrance in its products on this page, specifically in the Diamond Extreme moisturizer. In contrast, every product from Bayer on this page lists no fragrance in its ingredients.

## Research behind their key ingredients

- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- German skincare: [Bayer](https://lovi.care/skincare/sa/brands/bayer)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/sa/brands/natura-bisse)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/bayer-vs-natura-bisse
- United Kingdom: https://lovi.care/skincare/uk/compare/bayer-vs-natura-bisse
- Ireland: https://lovi.care/skincare/ie/compare/bayer-vs-natura-bisse
- Germany: https://lovi.care/skincare/de/compare/bayer-vs-natura-bisse
- France: https://lovi.care/skincare/fr/compare/bayer-vs-natura-bisse
- Italy: https://lovi.care/skincare/it/compare/bayer-vs-natura-bisse
- Netherlands: https://lovi.care/skincare/nl/compare/bayer-vs-natura-bisse
- Spain: https://lovi.care/skincare/es/compare/bayer-vs-natura-bisse
- Canada: https://lovi.care/skincare/ca/compare/bayer-vs-natura-bisse
- Australia: https://lovi.care/skincare/au/compare/bayer-vs-natura-bisse
- Singapore: https://lovi.care/skincare/sg/compare/bayer-vs-natura-bisse
- Saudi Arabia: https://lovi.care/skincare/sa/compare/bayer-vs-natura-bisse (this page)
- United Arab Emirates: https://lovi.care/skincare/ae/compare/bayer-vs-natura-bisse