# Avène vs Sebamed

Page: https://lovi.care/skincare/sa/compare/avene-vs-sebamed

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

Avène and Sebamed are European skincare brands rooted in distinct scientific traditions that offer specialized relief for demanding complexions. The French creator relies on nourishing [glycerin](https://lovi.care/skincare/sa/ingredients/glycerin) within versatile moisturizers, reliable sunscreens, targeted [serums](https://lovi.care/skincare/sa/ingredients/serum), and gentle cleansers to best suit acne-prone and oily skin without heaviness. Meanwhile, the German counterpart utilizes scientifically balanced formulas in thoughtful moisturizers and gentle cleansers to best suit sensitive, reactive, and problematic skin through a skin-neutral pH. While both prioritize barrier health, they differ fundamentally as the former addresses concerns like dark spots and aging through specialized formulations, whereas the latter maintains a steady focus on maintaining natural skin equilibrium.

Avène is a French skincare brand founded in 1990 and owned by Fondation Pierre Fabre.

[pierre-fabre.com](https://www.pierre-fabre.com/en/our-company/governance) [avene.co.uk](https://www.avene.co.uk/a/water-that-makes-all-the-difference-thermal-spring-water) [aveneusa.com](https://www.aveneusa.com/history)

Sebamed is a German skincare brand founded in 1967 and owned by Sebapharma GmbH & Co. KG.

[sebamed.ae](https://sebamed.ae/en/article/2/Sebapharma) [sebamed.com](https://sebamed.com/en/info/company/about-us/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Sebamed) [de.wikipedia.org](https://de.wikipedia.org/wiki/Sebamed)

This page compares some of the most popular Avène and Sebamed products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg51988d3f80).

### Popular Avène vs Sebamed products

#### Sebamed

- [Clear Face Care Gel](https://lovi.care/skincare/sa/p/sebamed/clear-face-care-gel/for/oily-acne-prone-skin) — High fit — [SAR 80.00 at Amazon](https://www.amazon.sa/dp/B0CD5VSPT3?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Facial Cleanser](https://lovi.care/skincare/sa/p/sebamed/facial-cleanser/for/combination-skin) — High fit

#### Avène

- [Cicalfate+ Restorative Protective Cream](https://lovi.care/skincare/sa/p/avene/cicalfate-restorative-protective-cream/for/dry-skin) — High fit — [SAR 83.90 at Amazon](https://www.amazon.sa/dp/B07YBCJBG2?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Cleanance](https://lovi.care/skincare/sa/p/avene/cleanance/for/oily-skin) — Superior fit — [SAR 93.00 at Amazon](https://www.amazon.sa/dp/B01MQWXZNV?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Cleanance Cleansing Gel](https://lovi.care/skincare/sa/p/avene/cleanance-cleansing-gel/for/oily-acne-prone-skin) — High fit — [SAR 93.00 at Amazon](https://www.amazon.sa/dp/B01MQWXZNV?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [Hydrance+](https://lovi.care/skincare/sa/p/avene/hydrance/for/dry-sensitive-skin) — Average fit
- [Tolerance Control Soothing Skin Recovery Balm](https://lovi.care/skincare/sa/p/avene/tolerance-control-soothing-skin-recovery-balm/for/dry-skin) — Superior fit — [SAR 235.36 at Amazon](https://www.amazon.sa/dp/B08XYVMRP7?tag=lovisa02-21&linkCode=osi&th=1&psc=1)
- [RetrinAL EYES](https://lovi.care/skincare/sa/p/avene/retrinal-eyes/for/dry-skin) — High fit
- [Cold Cream](https://lovi.care/skincare/sa/p/avene/cold-cream/for/dry-sensitive-skin) — High fit
- [Vitamin Activ Cg Radiance Concentrated Serum](https://lovi.care/skincare/sa/p/avene/vitamin-activ-cg-radiance-concentrated-serum/for/mature-skin) — High fit — [SAR 228.00 at Amazon](https://www.amazon.sa/dp/B0CNKJTV1X?tag=lovisa02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Avène or Sebamed: which is better?

Avène is better for a wider variety of skincare needs because the products on this page offer fifteen options spanning cleansers, [serums](https://lovi.care/skincare/sa/ingredients/serum), sunscreens, and moisturizers with a Lovi fit level of High for dry, sensitive, and mature skin types. In comparison, Sebamed features only two products on this page, which limits your routine choices. Reviewers mostly mention that Avène sunscreens are gentle and non-stripping.

### What is the difference between Avène and Sebamed?

Avene offers a much wider variety of products on this page across many categories like sunscreens, serums, and masks with different Lovi fit levels for various skin types, while Sebamed features only two products on this page. Additionally, Avene includes fragrance in some of its formulas, whereas every product on this page from Sebamed lists no fragrance.

### Avène or Sebamed: which cleanser is better?

For cleansers, Avène has a wider range on this page with options like Cleanance Cleansing Gel and Milk Cleanser, which Lovi rates as High for several skin types. Sebamed also offers a Facial Cleanser that Lovi rates as High for combination, oily, and acne-prone skin.

### Which is more affordable, Avène or Sebamed?

The page facts do not provide pricing information to determine whether Avene or Sebamed is more affordable, though reviewers sometimes note Avene's price point.

### Which causes fewer breakouts, Avène or Sebamed?

When looking at the products on this page, both Avène and Sebamed offer options that help with acne-prone and oily acne-prone skin. Lovi rates Sebamed Facial Cleanser as High for oily acne-prone skin, while Avène offers multiple products with High or Average fit levels for acne-prone skin.

### Where and when were Avène and Sebamed founded, and who owns them?

Avène was founded in 1990 in France and is owned by Fondation Pierre Fabre, whereas Sebamed was founded in 1967 in Germany and is owned by Sebapharma GmbH & Co. KG.

### How many products listed for Avène contain no fragrance compared to Sebamed?

7 of the 15 Avène products on this page list no fragrance, while every product listed for Sebamed lists no fragrance.

### Which Avène products achieve a Superior fit level for dry skin?

On this page, Eau Thermale [Thermal Spring Water](https://lovi.care/skincare/sa/ingredients/thermal-water) is the only Avène product that achieves a Superior fit level for dry skin.

### Avène or Sebamed: which moisturizer is better?

For moisturizers, Avène provides a wider variety of options on this page with varying Lovi fit levels for different skin types, whereas Sebamed offers a single option, Clear Face Care Gel, which has an average or high fit across several skin types.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Ascorbic acid activ cg · Experimental Dermatology, 2003
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol, Bakuchiol · The British Journal of Dermatology, 2019
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/22270204/) Copper sulfate · Journal of Drugs in Dermatology, 2012
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel bark extract · Phytochemistry, 2001
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells](https://pubmed.ncbi.nlm.nih.gov/25940647/) Rubus idaeus fruit extract raspberry fruit extract · International Journal of Cosmetic Science, 2015
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023
- [A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies](https://pubmed.ncbi.nlm.nih.gov/28203099/) Tocopheryl glucoside · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Efficacy and safety of non-thermal nitrogen plasma versus long-pulsed Nd:YAG laser for hand rejuvenation](https://pubmed.ncbi.nlm.nih.gov/33420853/) Nitrogen · Lasers in Medical Science, 2022
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Citric acid · Journal of Cosmetic Dermatology, 2021
- [Comparative benefit of two thermal spring waters after photodynamic therapy procedure](https://pubmed.ncbi.nlm.nih.gov/17348993/) Avène thermal spring water, Avene thermal spring water avene aqua · Journal of Cosmetic Dermatology, 2007
- [Wax-oil lubricants to reduce the shear between skin and PPE](https://pubmed.ncbi.nlm.nih.gov/34078980/) Paraffinum liquidum mineral oil · Scientific Reports, 2021
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function](https://pubmed.ncbi.nlm.nih.gov/35315151/) Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties](https://pubmed.ncbi.nlm.nih.gov/33848378/) Tocopheryl glucoside · International Journal of Cosmetic Science, 2021
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Citric acid · Journal of Drugs in Dermatology, 2013
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Clinical evaluation of anaesthetic-like effect of two dermocosmetic formulations containing Aquaphilus dolomiae extract-G3 in subjects with sensitive facial skin](https://pubmed.ncbi.nlm.nih.gov/35315150/) Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022
- [The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing](https://pubmed.ncbi.nlm.nih.gov/38451421/) Aquaphilus dolomiae extract filtrate · Dermatology and Therapy, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin](https://pubmed.ncbi.nlm.nih.gov/32870553/) Thermal spring water, Aqua dolomiae extract · Journal of the European Academy of Dermatology and Venereology, 2020
- [Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study](https://pubmed.ncbi.nlm.nih.gov/38553920/) Avène thermal spring water, Avene thermal spring water avene aqua, Thermal spring water · The Medical Journal of Malaysia, 2024
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc gluconate · Journal of Cosmetic Dermatology, 2026
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects](https://pubmed.ncbi.nlm.nih.gov/31347768/) Arginine · Journal of Cosmetic Dermatology, 2020
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types](https://pubmed.ncbi.nlm.nih.gov/40978887/) Cetyl alcohol · Cureus, 2025
- [Dermatological Effects of a Beeswax-Pine Resin Mixture on Abdominal Skin: A Proof-of-Concept Study Supporting the Development of an Affordable Investigational Ostomy Pouching System in Low-Income Regions](https://pubmed.ncbi.nlm.nih.gov/42758164/) Beeswax cera alba cera · Journal of Wound, Ostomy, and Continence Nursing, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- French skincare: [Avène](https://lovi.care/skincare/sa/brands/avene)
- German skincare: [Sebamed](https://lovi.care/skincare/sa/brands/sebamed)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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