# Youth To The People Polypeptide-121 Future Cream for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Youth To The People](https://lovi.care/skincare/brands/youth-to-the-people)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing for your combination skin due to hydrolyzed hyaluronic acid and sh-polypeptide-121, which hydrate and plump effectively while niacinamide helps manage oily shine.
- The formulation includes advanced biotech proteins and plant-based ingredients that are known for their effectiveness in addressing oily shine, making it suitable for your skincare needs.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the presence of soothing components like aloe barbadensis leaf juice and bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Biotech Collagen, Hydrolyzed Hyaluronic Acid, Niacinamide, Acetyl Tetrapeptides, Aloe Barbadensis Leaf Juice

## What the research says

- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation. ([Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## What reviewers say

Based on a very large amount of data, users with dry and sensitive skin frequently praise this cream for its ability to provide deep, long-lasting hydration without feeling heavy, often describing a "dewy" and "plump" finish. Many appreciate its barrier-strengthening ingredients and lightweight texture under makeup. Some users with oily or acne-prone skin experienced breakouts, and others found the price point too high for the amount of product provided.

- Liked: Deep hydration (mostly mentioned)
- Liked: Lightweight texture (mostly mentioned)
- Liked: Makeup compatibility (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Soothing formula (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Unhygienic packaging (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Youth To The People Polypeptide-121 Future Cream a great fit for combination skin?

Youth To The People Polypeptide-121 Future Cream is a great fit because it hydrates and plumps effectively with hydrolyzed hyaluronic acid and biotech collagen while niacinamide helps manage oily shine. Soothing ingredients like aloe leaf juice and bisabolol help keep the skin calm and comfortable without irritation.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit for your combination skin because hydrolyzed hyaluronic acid and biotech collagen hydrate and plump, while niacinamide helps manage oily shine. Soothing ingredients like aloe leaf juice and bisabolol also make it very gentle, with an excellent safety profile that is unlikely to cause irritation.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### What does Biotech Collagen do for combination skin?

Biotech Collagen helps balance combination skin by supporting moisture and keeping the skin barrier strong and smooth. It is unlikely to cause irritation and may improve skin elasticity and hydration.
Sources: [International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/39341309/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41952536/)

### What does Hydrolyzed Hyaluronic Acid do for combination skin?

Hydrolyzed hyaluronic acid helps keep combination skin hydrated and balanced without feeling heavy. It draws moisture into the skin while being lightweight enough to avoid making oily areas slick.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning and after your treatment step at night. It helps keep your skin balanced by hydrating dry areas while managing oily shine.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the moisturizer first to help lower the likelihood of dryness and irritation. Using a gentle moisturizer alongside retinoids improves skin comfort and helps maintain the skin barrier during treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22648223/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your combination skin hydrated and smooth. Daily application helps improve skin moisture and keeps the skin barrier healthy and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin. It features a very safe formula with soothing ingredients that help keep skin calm without heavy oils.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as its gentle formula works well on thinner and delicate skin areas. Regular application helps keep these areas hydrated and smooth while maintaining a very safe profile.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — $15.50 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — $49.95 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — $12.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — $14.97 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Dicaprylyl Carbonate, Hydrolyzed Hyaluronic Acid, Trimethylolpropane Tricaprylate Tricaprate, Tridecyl Trimellitate, Propanediol, Sh-Polypeptide-121, Polyglyceryl-3 Methylglucose Distearate, Panthenol, Niacinamide, Proline, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Cannabis Sativa Seed Extract Cannabis Sativa Seed Extract, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Salvia Hispanica Seed Extract, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Hibiscus Sabdariffa Fruit Extract, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Hydrolyzed Linseed Seed, Castor Ipdi Copolymer Oil, Ceramide Ap, Ceramide Np, Cetearyl Alcohol, Cetearyl Glucoside, Glycerin, Hydrolyzed Sodium Hyaluronate, Coco-Caprylate Caprate, Dilinoleic Acid Propanediol Pdi Crosspolymer, Benzyl Alcohol, Zingiber Officinale Root Extract, Bisabolol, Caprylyl Glycol, Carbomer, Dimethyl Isosorbide, Dipropylene Glycol, Erythritol, Ethylhexylglycerin, Glucose, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Glyceryl Monostearate, Phytosphingosine, Polyacrylate Crosspolymer-6, Polysorbate 20, Caprylhydroxamic Acid, Potassium Sorbate, Glycine, Hydroxyacetophenone, Sodium Benzoate, T-Buty Alcohol, Citric Acid, Sodium Citrate, Sodium Lactate, Triheptanoin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin