# Vichy Liftactiv Pure Retinol Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Vichy](https://lovi.care/skincare/brands/vichy)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for minimizing fine lines and wrinkles due to the presence of retinol and palmitoyl tripeptide-1, which are supportive for combination skin by regulating desquamation and providing humectant action.
- Glycerin and sodium hyaluronate offer general hydration benefits that can help with oily shine, though specialized ingredients to directly address this concern are lacking.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Sodium Hyaluronate, Palmitoyl Tetrapeptide-7, Hydrolyzed Rice Protein, Glycerin

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Vichy Liftactiv Pure Retinol work for combination skin?

Vichy Liftactiv Pure Retinol Serum works moderately well for combination skin by smoothing fine lines and providing basic hydration, though other products fit this skin type better. To work best for combination skin, this type of product needs ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness and add radiance without any risk of imbalance.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for combination skin?

This serum works for combination skin because retinol helps smooth out fine lines, while glycerin and sodium hyaluronate provide general hydration. To be a better fit for this skin type, a product of this type needs ingredients like niacinamide and zinc PCA to manage oily shine and keep the skin balanced.

### What does Retinol do for combination skin?

Retinol helps smooth fine lines, even out skin tone, and improve firmness in combination skin. It works by encouraging faster skin renewal and boosting collagen, though it may occasionally cause mild dryness or scaling while your skin adjusts.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Combination skin works best with products of this type that also include specialized ingredients to directly balance oily shine while providing hydration and smoothing fine lines.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and this retinol serum at night to keep your skin calm. Using them at different times of day helps prevent dryness and irritation while still smoothing fine lines.

### How often should I use this serum?

This serum works well in the evening for your combination skin, starting slowly to see how your skin feels. Combination skin needs products with mattifying ingredients to control oily shine along with gentle smoothing treatments.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause irritation or breakouts on combination skin because it avoids harsh ingredients, but you may experience mild initial purging from the retinol as it speeds up skin cell renewal. To work best for combination skin, this type of product also needs specialized ingredients that directly control oily shine.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Pentylene Glycol, Isononyl Isononanoate, Alcohol Denat, Dicaprylyl Ether, Glycine Soja Oil, Soybean Oil, Propylene Glycol, Peg-6 Caprylic Capric Glycerides, Hydrolyzed Rice Protein, Hydroxyacetophenone, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Vitreoscilla Ferment, Retinol, Dicaprylyl Carbonate, Ammonium Polyacryloyldimethyl Taurate, Butylene Glycol, Caprylyl Glycol, Carbomer, Glyceryl Isostearate, Polysorbate 20, Ppg-6-Decyltetradeceth-30, Sodium Lactate, Tocopherol, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin