# Theramid Copper Peptide for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/theramid/copper-peptide/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Theramid](https://lovi.care/skincare/brands/theramid)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for combination skin, as copper tripeptide-1 and bifida lysate ferment support barrier repair and collagen stimulation, but lacks targeted ingredients for your acne, blemishes, and breakouts.
- The presence of acetyl hexapeptide-1 and other peptides provides excellent skin repair and anti-aging benefits, though these are secondary to your primary concern of managing acne.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/theramid/copper-peptide/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/theramid/copper-peptide/for/oily-acne-prone-skin): High

## Key ingredients

Copper Tripeptide-1, Acetyl Tetrapeptide-2, Sodium Hyaluronate, Bifida Lysate Ferment, Acetyl Glutamine

## What the research says

- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases. ([Inflammation Research, 2010](https://pubmed.ncbi.nlm.nih.gov/20703511/))
- Treatment of immortalized human keratinocytes with Acetyl Tetrapeptide-2 increased cell stiffness across its concentration range, while Acetyl Hexapeptide-50 increased stiffness at 0.05 µg/ml but decreased it at 0.5 and 5 µg/ml compared to untreated controls. ([International Journal of Peptide Research and Therapeutics, 2018](https://pubmed.ncbi.nlm.nih.gov/30416406/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

A lightweight, fast-absorbing texture is frequently praised, and a moderate number of users report a boost in skin radiance. Some users find the high silicone content problematic for layering and note that copper peptides require careful routine planning to avoid conflicts with other active ingredients.

- Liked: Improves firmness (often mentioned)
- Liked: Lightweight, fast-absorbing (often mentioned)
- Liked: Boosts radiance (sometimes noted)
- Liked: Gentle, non-irritating (sometimes noted)
- Disliked: Hard to combine (sometimes noted)
- Disliked: High silicone content (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Theramid Copper Peptide Serum work for acne-prone skin?

Theramid Copper Peptide works moderately well for acne-prone skin because its ingredients support barrier repair and collagen, though it lacks targeted acne-fighting ingredients. For a better fit, acne-prone skin needs products containing ingredients like niacinamide, propolis, and zinc PCA to manage breakouts while maintaining hydration.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because copper tripeptide-1 and bifida lysate ferment help repair the skin barrier and calm redness. However, acne-prone skin needs a treatment with ingredients like niacinamide, zinc PCA, and propolis to directly target blemishes and control oil.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Copper Tripeptide-1 do for acne-prone skin?

Copper Tripeptide-1 helps calm acne-prone skin by reducing inflammation and supporting overall skin repair. Because this is a weaker match for your skin, an ideal product of this type needs soothing ingredients and gentle hydrators to calm irritation without clogging pores.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/29986520/)

### What does Acetyl Tetrapeptide-2 do for acne-prone skin?

Acetyl Tetrapeptide-2 helps improve the firmness and overall structural properties of acne-prone skin. This ingredient is unlikely to cause irritation and may support skin resilience, though acne-prone skin typically benefits most from additional soothing and blemish-clearing ingredients.
Sources: [International Journal of Peptide Research and Therapeutics, 2018](https://pubmed.ncbi.nlm.nih.gov/30416406/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Acne-prone skin needs a product of this type that also includes targeted ingredients to clear blemishes and breakouts.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol first and following with this treatment once it absorbs. This product is unlikely to cause irritation on your skin since it lacks harsh ingredients, but acne-prone skin needs products with targeted blemish-fighting ingredients to see clear results.

### How often should I use it?

Use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. Acne-prone skin works best with products that include targeted blemish-clearing ingredients and soothing agents to help manage breakouts.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or purging for acne-prone skin, as it contains no harsh ingredients that trigger irritation. However, because it lacks targeted ingredients for blemishes, acne-prone skin needs a product with blemish-fighting agents and lightweight, non-clogging hydrators for the best fit.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Cyclopentasiloxane, Dimethicone, Betaine, Copper Tripeptide-1, Bifida Lysate Ferment, Cyclohexasiloxane, Glycerin, Sodium Chloride, Polyglyceryl-4 Isostearate, Sodium Hyaluronate, Acetyl Tetrapeptide-2, Trifluoroacetyl Tripeptide-2, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Acetyl Hexapeptide-1, Bacillus Folic Acid Extract Ferment Filtrate, Cetyl Peg Ppg-10 1 Dimethicone, Hexyl Laurate, Peg Ppg-18 18 Dimethicone, Lecithin, Acetyl Glutamine, Caprylyl Glycol, Butylene Glycol, Dextran, Disodium Edta, Acetic Acid, Lactic Acid, 1,2-Hexanediol, Sodium Benzoate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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