# The Ordinary Retinol 0.5% in Squalane for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [The Ordinary](https://lovi.care/skincare/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers excellent visible anti-aging effects for your oily skin due to retinol's desquamation and seboregulation properties, complemented by squalane for emollient action without heaviness.
- While providing general hydration and anti-aging benefits, the formula lacks targeted ingredients to address your specific concerns of acne, blemishes, and breakouts.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Retinol, Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline. ([Forschende Komplementarmedizin, 2012](https://pubmed.ncbi.nlm.nih.gov/22585103/))
- Topical lycopene-based emulgel significantly enhanced skin hydration and elasticity while reducing erythema, melanin, and sebum contents in human volunteers compared to a placebo formulation over 12 weeks. ([European Journal of Pharmaceutics and Biopharmaceutics, 2022](https://pubmed.ncbi.nlm.nih.gov/36283632/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of an emollient emulsion containing 15.0% caprylic/capric triglyceride doubled the amount of urocanic acid isomers and increased skin hydration with reduced transepidermal water loss in healthy subjects, though it did not prevent ultraviolet-induced urocanic acid isomerization. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/37109405/))
- Topical application of jojoba wax reduced LPS-induced secretion of IL-6, IL-8, and TNFα by approximately 30% and increased the synthesis of pro-collagen III and hyaluronic acid compared to untreated skin in an ex-vivo human skin organ culture model. ([Frontiers in Pharmacology, 2024](https://pubmed.ncbi.nlm.nih.gov/38344180/))
- Topical jojoba oil application in male mice decreased exercise-induced pro-inflammatory gene expression (Il-1b and Il-6 in soleus, Il-1b in gastrocnemius) compared to untreated exercised mice. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41154623/))
- Nanolipidgel formulations with argan or jojoba oil and humectants demonstrate good sensory attributes, instrumental properties, and moisturizing efficacy for cosmetic application. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24772476/))
- Cosmetic formulations containing lycopene and melatonin showed significant differences in skin sebum content, hydration, elasticity, erythema index, and melanin index compared to control in 36 healthy women. ([Skin Pharmacology and Physiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33070140/))
- Topical delivery of lycopene via MG- and TG-containing microemulsions significantly increased stratum corneum and viable skin layer penetration compared to a control solution, with the MG-containing microemulsion also increasing skin antioxidant activity by 10-fold. ([Journal of Pharmaceutical Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/19798758/))
- Tomato-derived nanovesicles and extract accelerated wound closure and increased cell migration in human keratinocytes and mouse fibroblasts without affecting cell proliferation. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/38473700/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users generally praise this serum as an affordable and effective entry-level retinol that improves skin texture and reduces fine lines, though the oily squalane base is a polarizing feature. While many with dry or mature skin appreciate the added hydration, those with oily or acne-prone skin frequently report that it feels heavy, greasy, and can cause congestion or purging.

- Liked: Improves skin texture (mostly mentioned)
- Liked: Unbeatable price (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Reduces aging signs (often mentioned)
- Disliked: Greasy residue (often mentioned)
- Liked: Gentle effectiveness (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Short shelf life (sometimes noted)
- Disliked: Messy packaging (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Retinol 0.5% in Squalane work for oily acne-prone skin?

This product works fairly well for your oily skin by offering visible anti-aging effects, but it lacks targeted ingredients to address blemishes and breakouts. To truly fit oily and acne-prone skin, a treatment needs ingredients like niacinamide, propolis, or vitamin C to help with oil control and breakouts without feeling heavy.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this treatment a good fit for oily acne-prone skin?

Retinol makes this treatment a good fit by helping smooth and clear oily skin, while squalane gives lightweight moisture without feeling heavy. To truly suit oily and acne-prone skin, a product of this type needs targeted ingredients like niacinamide or vitamin C to tackle blemishes and control excess oil.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for oily acne-prone skin?

Retinol helps oily acne-prone skin by clearing up breakouts and smoothing the skin, though it may occasionally cause some mild scaling or stinging. This ingredient works by addressing the root causes of acne, making it a reliable choice for keeping pores clear and skin smooth.
Sources: [American Journal of Clinical Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30674002/), [Journal of Drugs in Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30586483/)

### What does Squalane do for oily acne-prone skin?

Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. Oily acne-prone skin needs a treatment with targeted blemish-fighting ingredients to help clear breakouts.

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment with vitamin C by applying vitamin C in the morning and this treatment at night, or by using them on alternate nights to keep your skin calm. Oily acne-prone skin needs a product of this type that also includes targeted blemish-fighting ingredients to properly clear breakouts.

### How often should I use this treatment?

Use this treatment in the evening, starting once a week and slowly increasing the frequency if your skin tolerates it well. This routine step helps smooth your skin safely, though this specific formula lacks targeted ingredients for acne and breakouts, so oily acne-prone skin needs added ingredients like salicylic acid or benzoyl peroxide to clear blemishes.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

Yes, this treatment may cause breakouts for your oily acne-prone skin, as some reviewers frequently report a greasy residue and blemishes. A product of this type needs targeted acne-fighting ingredients like salicylic acid or benzoyl peroxide to properly clear pores and prevent breakouts.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $9.30 (https://www.amazon.com/dp/B0789NX2ZV?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Retinol, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Hydroxymethoxyphenyl Decanone, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin