# The Ordinary Argireline Solution 10% for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [The Ordinary](https://lovi.care/skincare/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Suitable for normal skin, this formula utilizes acetyl hexapeptide-8 to offer moderate plumping and improve elasticity, while propanediol provides essential hydration.
- The product offers supportive benefits for redness and irritation, though it lacks specialized ingredients like niacinamide or centella asiatica that could more directly address your sensitivity.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Propanediol, Gellan Gum, Phenoxyethanol, Sodium Chloride

## What the research says

- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Oleuropein-rich gellan gum and sodium alginate hydrogel films acted as effective antioxidant and photoprotectant treatments against UVA-induced photoaging in normal human dermal fibroblasts. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37298828/))
- Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels scavenged 88.5% of free radicals, reduced transepidermal water loss by up to 33.3%, and improved moisture content and skin structural characteristics in a murine dry skin model. ([International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41224059/))
- Calcium hydroxylapatite diluted with normal saline combined with microfocused ultrasound with visualization improved age-related changes in the lower face, neck, and décolleté and stimulated collagen and elastin fibers in 20 subjects. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32272518/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance. ([Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38130575/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid serum decreased postoperative edema and erythema and increased basic fibroblast growth factor expression in fifteen healthy adults compared to vehicle control. ([Lasers in Surgery and Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26612341/))

## What reviewers say

Based on a very large amount of data, users frequently describe this serum as "Botox in a bottle," praising its ability to soften dynamic facial lines, particularly on the forehead and around the eyes. While many with mature or expressive skin report smoother texture and reduced wrinkle depth with consistent use, a notable portion of users saw no visible difference, suggesting efficacy varies significantly by skin type and depth of lines.

- Liked: Softens dynamic lines (mostly mentioned)
- Liked: Affordable price point (often mentioned)
- Liked: Lightweight watery texture (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Too runny/watery (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Results take time (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Argireline Solution work for sensitive skin?

The Ordinary Argireline Solution 10% works as an average fit for sensitive skin, offering supportive benefits for redness and irritation alongside moderate plumping from acetyl hexapeptide-8 and hydration from propanediol. However, because it lacks specialized ingredients like niacinamide or centella asiatica to more directly address sensitivity, a treatment for this skin needs soothing ingredients, potent antioxidants, and skin-repairing components to deliver optimal results safely.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/)

### Which ingredients make this serum a good fit for sensitive skin?

Acetyl Hexapeptide-8 and propanediol make this serum work for sensitive skin by offering moderate plumping and hydration. Treatments that fit sensitive skin better need calming ingredients like niacinamide or centella asiatica to directly address redness and irritation.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Argireline do for sensitive skin?

Argireline is unlikely to cause irritation and is sometimes found in products designed to calm reactive skin. Studies show it helps smooth the look of wrinkles and decrease skin roughness when used consistently.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Pharmaceuticals, 2021](https://pubmed.ncbi.nlm.nih.gov/34451799/)

### What does Propanediol do for sensitive skin?

Propanediol helps increase skin hydration and keeps the skin barrier strong, which is especially helpful for keeping sensitive skin feeling calm and smooth. It has a very safe profile and is unlikely to cause irritation when applied to the skin.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in your evening routine after your soothing toner and before your moisturizer. It works for sensitive skin by offering moderate plumping and hydration, though this skin type needs a product with ingredients like niacinamide or centella asiatica to more directly address redness and irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment first and following with your retinol product, but this formula lacks specialized soothing ingredients like niacinamide or centella asiatica that could better protect sensitive skin.

### How often should I use this serum?

You can use this treatment in your evening routine, applying it after your toner and before your moisturizer. While it works for sensitive skin, a product for this skin needs soothing ingredients like niacinamide or centella asiatica to better calm redness and irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin. Its lightweight, water-based formula absorbs easily without heavy oils that typically trigger blemishes.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — $39.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

- Amazon.com: $9.70 (https://www.amazon.com/dp/B072JH13CD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin, Ethoxydiglycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/argireline-solution-10/for/sensitive-skin