# The Ordinary Argireline Solution 10% for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [The Ordinary](https://lovi.care/skincare/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate plumping for your oily skin due to Acetyl Hexapeptide-8, which helps reduce the appearance of wrinkles by inhibiting muscle contractions, though it does not target your primary concerns of acne and oiliness.
- The formulation provides general skincare benefits like hydration and cleansing, but lacks specific ingredients to address your acne, blemishes, and breakouts or oiliness.
- The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Acetyl Hexapeptide-8, Propanediol, Gellan Gum, Phenoxyethanol, Sodium Chloride

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Oleuropein-rich gellan gum and sodium alginate hydrogel films acted as effective antioxidant and photoprotectant treatments against UVA-induced photoaging in normal human dermal fibroblasts. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37298828/))
- Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels scavenged 88.5% of free radicals, reduced transepidermal water loss by up to 33.3%, and improved moisture content and skin structural characteristics in a murine dry skin model. ([International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41224059/))
- Calcium hydroxylapatite diluted with normal saline combined with microfocused ultrasound with visualization improved age-related changes in the lower face, neck, and décolleté and stimulated collagen and elastin fibers in 20 subjects. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32272518/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance. ([Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38130575/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users frequently describe this serum as "Botox in a bottle," praising its ability to soften dynamic facial lines, particularly on the forehead and around the eyes. While many with mature or expressive skin report smoother texture and reduced wrinkle depth with consistent use, a notable portion of users saw no visible difference, suggesting efficacy varies significantly by skin type and depth of lines.

- Liked: Softens dynamic lines (mostly mentioned)
- Liked: Affordable price point (often mentioned)
- Liked: Lightweight watery texture (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Too runny/watery (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Results take time (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Argireline Solution 10% work for oily acne-prone skin?

This treatment works moderately well for your oily acne-prone skin, as it helps smooth wrinkles with Acetyl Hexapeptide-8 and provides light hydration, though it does not target acne or excess oil. A treatment of this type needs ingredients like niacinamide, propolis, or Vitamin C to control oil and breakouts while keeping your skin calm and clear.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Acetyl Hexapeptide-8 makes this serum a moderate fit by helping reduce the appearance of wrinkles, though this product lacks the specific ingredients to address acne and excess oil. Oily acne-prone skin needs a treatment with ingredients like niacinamide, propolis, or Vitamin C to control oil and clear breakouts while keeping the skin comfortable and balanced.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Argireline do for oily acne-prone skin?

Argireline is unlikely to treat acne or oiliness directly, as it focuses on reducing fine lines and making skin smooth. Oily acne-prone skin needs lightweight, non-greasy ingredients that clear pores and calm breakouts.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Propanediol do for oily acne-prone skin?

Propanediol helps oily, acne-prone skin by reducing skin oiliness and calming breakouts. Research shows that it may decrease acne-causing bacteria and lower oil production when used regularly in your routine.
Sources: [Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, as suggested for simplicity and extra safety around sun exposure. To properly care for oily acne-prone skin, a product of this type needs acne-fighting ingredients like salicylic acid or benzoyl peroxide and oil-controlling elements to address breakouts and excess shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment after cleansing and before your moisturizer, while introducing them gradually to ensure your skin stays calm. This lightweight product is unlikely to cause irritation on oily skin, but to better manage breakouts and oiliness, your routine needs targeted ingredients like salicylic acid or benzoyl peroxide.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this treatment once a day in the evening as part of your routine. It is safe for oily skin and helps smooth fine lines, but oily acne-prone skin also needs dedicated ingredients that clear pores, reduce breakouts, and balance oil.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for oily acne-prone skin since it has a very safe formula with no harsh or heavy ingredients. However, it does not treat acne or oiliness, so an oily acne-prone skin still needs ingredients like salicylic acid or niacinamide to help clear blemishes and control oil.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $9.70 (https://www.amazon.com/dp/B072JH13CD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin, Ethoxydiglycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin