# The INKEY List Niacinamide Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [The INKEY List](https://lovi.care/skincare/brands/the-inkey-list)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate pore-clearing and skin-evening benefits for your combination skin, as niacinamide helps regulate sebum and improve texture, while glycerin provides essential hydration. However, the formula lacks specialized ingredients like salicylic acid to directly target your acne, blemishes, and breakouts.
- The product is safe for your combination skin due to the absence of harsh ingredients and the inclusion of soothing components like panthenol and allantoin.
- Overall, it provides general skincare benefits that support skin health without directly addressing your primary concerns.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glycerin, Squalane, Sodium Hyaluronate, Leuconostoc Radish Root Ferment Filtrate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users with oily and blemish-prone skin frequently praise this serum for its ability to regulate sebum production and calm active breakouts without stripping moisture. The majority report clearer skin and reduced redness. A notable minority experience texture issues, such as a sticky finish or white residue if the product is not applied carefully.

- Liked: Controls excess oil (often mentioned)
- Liked: Great value & packaging (often mentioned)
- Liked: Reduces redness & blemishes (often mentioned)
- Liked: Hydrating & lightweight (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Sticky or tacky finish (sometimes noted)
- Disliked: White residue/crystallization (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Foaming/soaping effect (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The INKEY List Niacinamide work for acne-prone skin?

This serum works moderately well for acne-prone skin, as it helps balance oil and smooth texture, but it lacks targeted ingredients like salicylic acid to directly clear breakouts. Products of this type need specialized ingredients like salicylic acid or zinc to tackle acne, along with soothing components to keep skin calm.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for your acne-prone skin because niacinamide helps regulate oil and smooth texture, while glycerin, squalane, and sodium hyaluronate provide essential hydration without making you greasy. Panthenol and allantoin also help keep your skin calm and comfortable. To truly target breakouts and blemishes, a product of this type needs specialized ingredients like salicylic acid or zinc PCA.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine, after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying it after your cleanser and hydrating toner in your evening routine, followed by your moisturizer. This product helps provide general hydration and support skin health, but acne-prone skin also needs specialized ingredients like salicylic acid to directly target breakouts.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. An acne-prone skin type needs a product with specialized ingredients like salicylic acid to directly target breakouts and blemishes.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

The INKEY List Niacinamide Serum is unlikely to clog pores, but it may cause breakouts for some people since it lacks specialized ingredients like salicylic acid to directly target acne. To better fit acne-prone skin, this type of product needs targeted blemish-clearing ingredients like salicylic acid.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

- Amazon.com: $13.00 (https://www.amazon.com/dp/B09N9Z7NBS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Propanediol, Butylene Glycol, Phenoxyethanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Squalane, Xanthan Gum, Glycine Soja Oil Soybean Oil, Allantoin, Sodium Phytate, Polysorbate 60, Panthenol, Glycolipids, Leuconostoc Radish Root Ferment Filtrate, Sorbitan Isostearate, Glycine Soja Soybean Sterols, Citric Acid, Sodium Hyaluronate, Disodium Phosphate, Sodium Phosphate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin