The History of Whoo HwanYu Essence for skin with dark spots

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What the research says

• Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation.

  Biological & Pharmaceutical Bulletin, 2019

• Ginsenoside Rf inhibited Forskolin- or UV-stimulated melanogenesis, downregulating cellular tyrosinase activity and the expression of MITF, tyrosinase, and Tyrps in melanocytes and ex vivo human skin by mitigating PKA activity and CREB phosphorylation.

  Journal of Ginseng Research, 2021

• A mixture of Panax ginseng and Crataegus pinnatifida prevented skin aging by improving procollagen type I expression, diminishing matrix metalloproteinase-1 secretion, reducing skin roughness and photodamage scores, and decreasing loss of skin moisture in human dermal fibroblasts and healthy human skin.

  Journal of Ginseng Research, 2017

• Panax ginseng root extract induced Type I procollagen synthesis and COL1A2 promoter activity through Smad2 phosphorylation in human dermal fibroblast cells.

  Journal of Ethnopharmacology, 2007

• Deer antler velvet extract-loaded niosomes and microspicules serum applied on the human scalp significantly enhanced hair elongation and melanin content while promoting hair growth without skin irritation compared to other formulations.

  International Journal of Pharmaceutics, 2021

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Cordyceps sinensis mycelium hydroethanolic extract increased sirtuin expression, NAD+ synthesis, ATP production, collagen synthesis, and reduced ROS and wrinkles in in vitro assays and human subjects compared to controls.

  International Journal of Molecular Sciences, 2024

• Topical cream containing 0.2% Cordyceps militaris polysaccharide extract was safe and achieved over 70% overall preference in 20 female volunteers.

  Fungal Biology and Biotechnology, 2023

• A cordycepin/chitosan hydrogel dressing served as a quicker re-epithelization of skin wounds and an apparent increasing collagen deposition compared with chitosan hydrogels in vivo.

  International Journal of Biological Macromolecules, 2019

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Water, Dipropylene Glycol, Cyclopentasiloxane, Glycerin, Panax Ginseng Root Extract, Pca Dimethicone, Perfluorononylethyl Stearyl Dimethicone, Trehalose, Polygonum Multiflorum Root Extract, Sucrose Polystearate, Isostearyl Isostearate, Butylene Glycol, Velvet Extract, 1,2-Hexanediol, Dimethicone, Bis-Peg-18 Methyl Ether Dimethyl Silane, Cordyceps Sinensis Extract, Caprylyl Trimethicone, Algae Extract, Beeswax, Saussurea Involucrata Extract, Panthenol, Glyceryl Stearate, Peg-100 Stearate, Dimethiconol, Phytosteryl Isostearyl Cetyl Stearyl Behenyl Dimer Dilinoleate, Asparagus Cochinchinensis Root Extract, Polygonatum Officinale Root Extract Rhizome, Stearic Acid, Hydrogenated Polydecene, Ziziphus Jujuba Fruit Extract, Punica Granatum Fruit Extract, Hydrogenated Polyisobutene, C14-22 Alcohols, Squalane, Cimicifuga Racemosa Root Extract, Dioscorea Japonica Root Extract, Trifolium Pratense Leaf Extract, Lithospermum Erythrorhizon Root Extract, Juglans Regia Seed Extract, Tuber Melanosporum Extract, Ceramide Np, Hydrogenated Lecithin, Glycosphingolipids, Ammonium Acryloyldimethyltaurate Vp Copolymer, Angelica Acutiloba Root Extract, Triethylhexanoin, Macadamia Ternifolia Seed Oil, Tromethamine, Carbomer, Pogostemon Cablin Leaf Extract, Panax Ginseng Stem Extract Leaf, Cornus Officinalis Fruit Extract, Clove Flower Extract, Zingiber Officinale Root Extract, Arachidyl Glucoside, Butyrospermum Parkii Butter Shea Butter, Poria Cocos Sclerotium Extract, Thymus Vulgaris Extract, Prunus Armeniaca Kernel Extract Apricot Kernel Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Cyperus Rotundus Root Extract, Mica, Phellodendron Amurense Bark Extract, Schizandra Chinensis Fruit Extract, Rehmannia Glutinosa Root Extract, Laminaria Japonica Extract, Anemarrhena Asphodeloides Root Extract, Chaenomeles Sinensis Fruit Extract, Paeonia Albiflora Root Extract, Polygonum Aviculare Extract, Prunella Vulgaris Leaf Extract, Cuscuta Japonica Seed Extract, Lycium Chinense Fruit Extract, Cassia Obtusifolia Seed Extract, Eucommia Ulmoides Bark Extract, Cinnamomum Cassia Bark Extract, Titanium Dioxide Ci 77891, Paeonia Suffruticosa Root Extract, Lindera Strychnifolia Root Extract, Zanthoxylum Piperitum Fruit Extract, Citrus Unshiu Peel Extract, Poncirus Trifoliata Fruit Extract, Atractylodes Lancea Root Extract, Atractylodes Japonica Extract Rhizome, Prunus Persica Kernel Extract, Nelumbo Nucifera Seed Powder, Ganoderma Lucidum Stem Extract Mushroom Stem Extract, Dimocarpus Longan Fruit Extract, Amomum Xanthioides Seed Extract, Coptis Japonica Root Extract, Carthamus Tinctorius Seed Extract, Bambusa Textilis Stem Extract, Tricholoma Matsutake Extract, Glycereth-20, Cnidium Officinale Root Extract, Cholesterol, Peg-10 Rapeseed Sterol, Glycine Seed Extract Soybean Seed Extract, Trisodium Edta, Iron Oxides Ci 77491, Perilla Ocymoides Leaf Extract, Platycodon Grandiflorum Root Extract, Trichosanthes Kirilowii Root Extract, Houttuynia Cordata Extract, Belamcanda Chinensis Root Extract, Scutellaria Baicalensis Root Extract, Eriobotrya Japonica Leaf Extract, Schizonepeta Tenuifolia Extract, Tussilago Farfara Flower Extract, Ophiopogon Japonicus Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.