# SkinCeuticals Phloretin CF for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SkinCeuticals](https://lovi.care/skincare/brands/skinceuticals)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers excellent antioxidant protection for your normal skin due to ascorbic acid and ferulic acid, which shield from environmental stressors and support collagen synthesis.
- While beneficial for general skin health, these ingredients do not directly address your primary concerns of redness and irritation.
- The formulation is safe for your sensitive skin, as it lacks any harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/oily-acne-prone-skin): High

## Key ingredients

Phloretin, Ascorbic Acid, Ferulic Acid

## What the research says

- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Phloretin inhibits the growth of acne-related bacteria, attenuates P. acnes-induced inflammatory mediators in vitro, and significantly reduces comedo counts, sebum output, and porphyrin levels in subjects with whiteheads compared to before treatment. ([International Journal of Cosmetic Science, 2016](https://pubmed.ncbi.nlm.nih.gov/26212527/))
- Phloretin 3',3-disulfonate attenuated UVB-induced cyclobutane pyrimidine dimer formation, glutathione depletion, apoptosis, and inflammatory mediator release in skin cells by enhancing nucleotide excision repair gene expression. ([International Journal of Molecular Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25334063/))
- Compound 11c showed potent inhibitory activity against tyrosinase at nanomolar concentrations and reduced melanin content in a UV-induced skin pigmentation guinea pig model. ([Journal of Medicinal Chemistry, 2023](https://pubmed.ncbi.nlm.nih.gov/36940414/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Topical ferulic acid-containing formulations effectively reduce skin erythema, hyperpigmentation, and signs of aging in adults compared to baseline or alternative conditions. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40538529/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded for brightening the complexion, evening skin tone, and reducing discoloration such as dark spots and melasma, particularly benefiting those with normal, oily, combination, or acne-prone skin. Many users report achieving smoother, more radiant skin and a decrease in fine lines. However, a significant number of reviews mention the high cost, a strong scent, and occasional issues with stickiness or packaging.

- Liked: Brightens skin (mostly mentioned)
- Liked: Fades discoloration (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Good for oily skin (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SkinCeuticals Phloretin CF work for sensitive skin?

This serum is a safe and average fit for sensitive skin because it lacks harsh ingredients, though it does not directly target redness and irritation. Treatments that fit this skin better need ingredients like niacinamide and snail secretion filtrate to calm redness while protecting the skin.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/), [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### Which ingredients make this serum a good fit for sensitive skin?

Ascorbic acid and ferulic acid make this serum a good fit by offering strong antioxidant protection, though a treatment for sensitive skin also needs ingredients that directly soothe redness and irritation, like niacinamide.
Sources: [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/), [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/)

### What does Phloretin do for sensitive skin?

Phloretin helps protect sensitive skin from the redness and sun damage caused by ultraviolet rays. It is often combined with other antioxidants like vitamin C to calm skin and defend against daily environmental stress.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/), [International Journal of Molecular Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25334063/)

### What does Vitamin C do for sensitive skin?

Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, as treatments with active ingredients are placed in the PM for simplicity and extra safety around sun exposure. It is safe for your sensitive skin because it lacks harsh or prohibited ingredients, though a product of this type for sensitive skin ideally needs soothing ingredients that directly address redness and irritation.

### Can I use this serum with retinol, and in what order?

This treatment is safe for your sensitive skin because it lacks harsh ingredients, but it does not directly target redness and irritation. To fit this skin better, a product of this type needs calming and soothing ingredients that directly target redness and irritation.

### How often should I use it?

You can use this treatment in the evening once a week to start, as the formula is safe for sensitive skin but does not directly target redness and irritation. Sensitive skin needs treatments with soothing and calming ingredients like centella asiatica, niacinamide, or ceramides to help ease redness and comfort the skin.
Sources: [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for sensitive skin?

SkinCeuticals Phloretin CF is unlikely to clog pores or cause breakouts on sensitive skin, as it lacks harsh or prohibited ingredients that commonly cause irritation. However, because it does not directly target redness, sensitive skin types dealing with these concerns may benefit more from products featuring calming agents and soothing plant extracts.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — $39.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Dipropylene Glycol, Alcohol Denat, Ascorbic Acid, Butylene Glycol, Triethyl Citrate, Phloretin, Ferulic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinceuticals/phloretin-cf/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skinceuticals/phloretin-cf/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/skinceuticals/phloretin-cf/for/sensitive-skin
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