SkinCeuticals A.G.E. Advanced Eye for skin with dark spots

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients.

  Journal of Cosmetic Dermatology, 2025

• Bog blueberry anthocyanin-rich extract attenuated ultraviolet-B-induced toxicity, DNA damage, collagen degradation, and inflammatory cytokine release in human dermal fibroblasts by modulating NF-kappaB and MAPK signaling pathways.

  Molecular Nutrition & Food Research, 2009

• Application of a hydroxypropyl tetrahydropyrantriol and niacinamide formula following nonablative fractional laser treatment demonstrated comparable healing benefits to clinical control and significant improvements in fine lines, crow's feet wrinkles, skin roughness, and overall healthy appearance over 56 days in White and Northeast Asian panels.

  The Journal of Clinical and Aesthetic Dermatology, 2025

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects.

  Antioxidants, 2023

• Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models.

  Oxidative Medicine and Cellular Longevity, 2020

• Endogenous fermentation-derived blueberry metabolites reduced UV-induced 4-hydroxynonenal protein adducts by 47.4% ± 9.9%, increased hemeoxygenase-1 expression by 173% ± 26%, and mitigated elastin degradation by 82.8% ± 4.9% in ex vivo human skin biopsies compared to exogenous fermentation treatments and nonfermented berry compounds.

  Journal of Agricultural and Food Chemistry, 2026

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

Ingredients

Water, Glycerin, Dimethicone, Proxylane, Blueberry Extract, Caffeine, Phenoxyethanol, Caprylyl Glycol, Hyaluronic Acid, Disodium Edta, Hydroxyethylpiperazine Ethane Sulfonic Acid, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Triethanolamine, Chlorphenesin, Carbomer, Xanthan Gum, Sodium Hydroxide

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.