# Skinbetter Science Alto Defense Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Skinbetter Science](https://lovi.care/skincare/brands/skinbetter-science)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your dry skin, as Hydrolyzed Sodium Hyaluronate and Ceramide NP provide essential hydration and support your skin barrier. Tetrahexyldecyl ascorbate and ergothioneine offer good antioxidant protection against environmental stressors.
- The formula is generally safe for your dry skin, with Bisabolol and Glycerin included to soothe and prevent irritation.
- This product is well-suited for your dry skin type due to its humectant and barrier-repairing ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Vitis Vinifera Seed Extract Grape Seed Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Curcuma Longa Root Extract, Superoxide Dismutase, Tetrahexyldecyl Ascorbate

## What the research says

- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38828801/))
- Resveratrol cream improved skin hydration and tightening compared to cream without resveratrol in a group of probands. ([Acta Biochimica Polonica, 2019](https://pubmed.ncbi.nlm.nih.gov/31518087/))
- Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity. ([International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Most users report a more luminous and even complexion without irritation. A few users note the high price point, small packaging, and occasional lack of visible results.

- Liked: Improves skin texture (often mentioned)
- Liked: Reduces skin redness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Liked: Hydrates the skin (sometimes noted)
- Disliked: No visible results (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Defense Serum work for dry skin?

Skinbetter Science Alto Defense Serum works moderately well for dry skin, providing essential hydration and barrier support with ingredients like hydrolyzed sodium hyaluronate and ceramide NP. While it offers good antioxidant protection and soothing benefits, dry skin often needs richer hydration, intensive barrier-repairing ceramides, and nourishing ingredients like niacinamide or peptides for optimal results.

### Which ingredients make this serum a good fit for dry skin?

This serum works for dry skin because hydrolyzed sodium hyaluronate and ceramide NP provide essential hydration and support your skin barrier. To be an even better fit for dry skin, a product of this type needs additional rich hydrating ingredients like niacinamide, soothing peptides, or propolis to lock in moisture and nourish the skin deeply.

### What does Grape Seed Extract do for dry skin?

Grape seed extract helps increase skin hydration and improves moisture levels for dry skin. It is unlikely to cause irritation and protects skin cells from daily damage.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35403355/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32892461/)

### What does Licorice Root Extract do for dry skin?

Licorice root extract helps soothe dry skin by calming irritation and reducing redness. It also provides antioxidant protection to support overall skin health and comfort.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23549137/), [Pigment Cell Research, 1998](https://pubmed.ncbi.nlm.nih.gov/9870547/)

### Where does it go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, applying the treatment first and following with your retinol moisturizer. Dry skin needs rich hydrating ingredients like hyaluronic acid, ceramides, and nourishing plant oils to lock in moisture and keep the skin barrier strong when using strong actives.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### How often should I use it?

You can use this treatment in the evening as part of your routine. Dry skin needs ingredients like hyaluronic acid, ceramides, and rich oils to provide deep moisture and repair the barrier.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin. It contains soothing ingredients like bisabolol and glycerin that help prevent irritation and keep the skin calm.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Hydrolyzed Sodium Hyaluronate, Lauryl Lactate, Dimethyl Isosorbide, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Superoxide Dismutase, Ubiquinone, Zingiber Officinale Root Extract, Ceramide Np, Ceramide Ap, Ceramide Eop, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium Pca, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Wax Seed Sunflower Wax Seed, Acacia Decurrens Wax Flower, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Carbomer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dextran, Sodium Hydroxide, Citric Acid, Disodium Edta, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alto-defense-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/skinbetter-science/alto-defense-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinbetter-science/alto-defense-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alto-defense-serum/for/dry-skin