# Skinbetter Science Alto Defense Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Skinbetter Science](https://lovi.care/skincare/brands/skinbetter-science)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as ingredients like Glycerin and Sodium Hyaluronate provide essential hydration, though it lacks potent ingredients for optimal oil control on your oily T-zone areas.
- The serum provides excellent protection against environmental stressors due to antioxidants like Ergothioneine and Tetrahexyldecyl Ascorbate, which support general skin health.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the presence of soothing agents like Bisabolol and Licorice Root Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Vitis Vinifera Seed Extract Grape Seed Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Curcuma Longa Root Extract, Superoxide Dismutase, Tetrahexyldecyl Ascorbate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38828801/))
- Resveratrol cream improved skin hydration and tightening compared to cream without resveratrol in a group of probands. ([Acta Biochimica Polonica, 2019](https://pubmed.ncbi.nlm.nih.gov/31518087/))
- Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity. ([International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Most users report a more luminous and even complexion without irritation. A few users note the high price point, small packaging, and occasional lack of visible results.

- Liked: Improves skin texture (often mentioned)
- Liked: Reduces skin redness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Liked: Hydrates the skin (sometimes noted)
- Disliked: No visible results (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Defense Serum work for combination skin?

Skinbetter Science Alto Defense Serum works moderately well for combination skin, offering essential hydration and great protection against environmental stressors while keeping irritation unlikely. However, it lacks potent ingredients for optimal oil control on your oily T-zone areas. This skin type needs effective ingredients like niacinamide and zinc PCA that provide significant benefits for managing oily shine without any associated risks of irritation or unsuitability.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

This serum fits combination skin because glycerin and sodium hyaluronate provide essential hydration, while ergothioneine and tetrahexyldecyl ascorbate help protect against environmental stressors. To work best for combination skin, a product of this type needs effective ingredients like niacinamide, zinc PCA, and propolis to regulate oiliness and manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/)

### What does Grape Seed Extract do for combination skin?

Grape seed extract helps balance combination skin by managing oil levels while keeping dry areas hydrated and smooth. It is unlikely to cause irritation and may protect against everyday skin stress.
Sources: [International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/), [Pakistan Journal of Pharmaceutical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34799340/)

### What does Licorice Root Extract do for combination skin?

Licorice root extract helps calm redness and balances uneven tone on combination skin. It also protects skin from everyday stress and reduces irritation, making it a soothing addition to your routine.
Sources: [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/), [Anais Brasileiros de Dermatologia, 2010](https://pubmed.ncbi.nlm.nih.gov/21152784/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. To better fit combination skin, this type of product also needs potent ingredients for oil control on your oily T-zone areas.

### Can I use this serum with retinol, and in what order?

You can use this serum with a retinol, applying the treatment after your cleanser and toner, and following it with a moisturizer. This approach helps maintain hydration and general skin health while keeping your skin calm, though combination skin also needs potent ingredients for optimal oil control on your oily T-zone areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This treatment serum fits into your evening routine for simplicity and safety around sun exposure. It provides moderate suitability for your combination skin by delivering essential hydration, though this type of skin also needs potent ingredients for optimal oil control on your oily T-zone areas.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin because it has a very safe formula free of harsh irritants and includes soothing ingredients like Bisabolol and licorice root extract. However, to truly balance combination skin, a product of this type needs stronger oil-controlling ingredients for the oily T-zone.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Hydrolyzed Sodium Hyaluronate, Lauryl Lactate, Dimethyl Isosorbide, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Superoxide Dismutase, Ubiquinone, Zingiber Officinale Root Extract, Ceramide Np, Ceramide Ap, Ceramide Eop, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium Pca, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Wax Seed Sunflower Wax Seed, Acacia Decurrens Wax Flower, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Carbomer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dextran, Sodium Hydroxide, Citric Acid, Disodium Edta, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alto-defense-serum/for/combination-skin
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- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alto-defense-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alto-defense-serum/for/combination-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alto-defense-serum/for/combination-skin