# SKIN1004 Probio-Cica Intensive Ampoule for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SKIN1004](https://lovi.care/skincare/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your oily skin, as Centella Asiatica Extract and Niacinamide work synergistically to enhance skin barrier resilience and regulate sebum production, addressing your concerns with acne, blemishes, and oiliness.
- The inclusion of Butylene Glycol and Glycerin provides essential hydration without clogging pores, further supporting your skin's overall health and comfort.
- The product is safe for your skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycerin, Butylene Glycol, Propanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))

## What reviewers say

This ampoule is widely celebrated as a holy grail for repairing damaged skin barriers and soothing irritation, particularly for those with dry, sensitive, or acne-prone skin. Users consistently report a glass skin effect, noting that the milky, viscous texture provides deep hydration and calms redness without leaving a heavy residue. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Barrier repair (often mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle/non-irritating (often mentioned)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Texture heaviness (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin1004 Probio-Cica Intensive Ampoule a great fit for oily acne-prone skin?

This treatment is a great fit for your oily acne-prone skin because Centella Asiatica Extract and Niacinamide help calm blemishes and manage oil. Glycerin and Butylene Glycol add light hydration that is unlikely to clog pores. It also has a gentle formula with a very low risk of irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Centella Asiatica Extract and Niacinamide make this a great fit because they help calm blemishes and balance oil, while Glycerin and Butylene Glycol add light hydration without clogging pores. It has a high suitability for your skin and is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Centella Asiatica Extract do for oily acne-prone skin?

Centella Asiatica Extract helps calm red spots and supports skin healing in oily, acne-prone skin. It may also help balance moisture and reduce breakouts by soothing irritated areas.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep your routine simple and safe around sun exposure. It is a great fit for your oily skin because centella asiatica extract and niacinamide help calm breakouts and manage oil, while glycerin provides light hydration that is unlikely to clog pores.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to calm your skin and provide lightweight hydration, followed by your retinol. This pairing helps keep your oily skin comfortable and minimizes potential dryness without clogging pores.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use this serum?

This treatment fits into your evening routine for simplicity and safety, and you can start using it daily as your skin adjusts. Centella Asiatica Extract and Niacinamide help calm and balance your oily acne-prone skin without clogging pores.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily acne-prone skin, as it provides lightweight hydration and helps calm blemishes. While minor breakouts are a rare possibility, the formula is gentle and free of harsh ingredients that typically irritate your skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $19.26 (https://www.amazon.com/dp/B0CSDMNRGM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Propanediol, Caprylic Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Dipropylene Glycol, Polyglyceryl-4 Isostearate, Kidney Vetch
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin