# SKIN1004 Probio-Cica Intensive Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SKIN1004](https://lovi.care/skincare/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this ampoule leverages Centella Asiatica Extract and Niacinamide to significantly improve skin barrier resilience and address wrinkles and fine lines by supporting skin repair and collagen production.
- The moderate concentrations of these key ingredients ensure effective anti-inflammatory action and barrier repair, aligning well with your skin's needs.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycerin, Butylene Glycol, Propanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))

## What reviewers say

This ampoule is widely celebrated as a holy grail for repairing damaged skin barriers and soothing irritation, particularly for those with dry, sensitive, or acne-prone skin. Users consistently report a glass skin effect, noting that the milky, viscous texture provides deep hydration and calms redness without leaving a heavy residue. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Soothing and calming (mostly mentioned)
- Liked: Barrier repair (often mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle/non-irritating (often mentioned)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Texture heaviness (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Skin1004 Probio-Cica Intensive Ampoule a great fit for mature skin?

Skin1004 Probio-Cica Intensive Ampoule is a great fit for mature skin because it uses centella asiatica extract and niacinamide to help strengthen your skin barrier and smooth out wrinkles and fine lines. The moderate amounts of these ingredients soothe your skin and support collagen production safely without causing irritation. This product is unlikely to cause any harsh reactions while helping keep your skin looking firm and healthy.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

Centella Asiatica Extract and Niacinamide make this serum a great fit because they help repair your skin barrier, support collagen production, and smooth out fine lines. They work to calm your skin and improve overall firmness without causing irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in your evening routine after cleansing and toning, and before your moisturizer. Using it at night helps avoid any extra sensitivity from sun exposure, while its active ingredients support collagen production and smooth the look of fine lines.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following with this ampoule to keep your skin calm and comfortable. The formula is safe for your skin with no risks of irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This treatment is applied in the evening, making it simple and safe around sun exposure, though some can be used twice a day. It is unlikely to cause irritation and helps improve fine lines and skin repair.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Can it clog pores, cause breakouts or purging for mature skin?

This ampoule is unlikely to cause breakouts or clog pores for mature skin, as it has a very low rate of complaints for potential breakouts and contains gentle, calming ingredients. It helps support skin repair and barrier resilience without harsh additives that typically trigger irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — $810.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

- Amazon.com: $19.26 (https://www.amazon.com/dp/B0CSDMNRGM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Propanediol, Caprylic Capric Triglyceride, Niacinamide, 1,2-Hexanediol, Dipropylene Glycol, Polyglyceryl-4 Isostearate, Kidney Vetch
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin