# SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SKIN1004](https://lovi.care/skincare/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin and acne concerns is provided by Lactobacillus Centella Asiatica Extract Ferment Filtrate and Centella Asiatica Extract, which offer potent anti-inflammatory action and barrier repair to soothe blemishes.
- Ceramide NP and polyhydroxystearic acid further enhance skin barrier resilience and hydration, supporting overall skin health without clogging pores.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Allantoin, Panthenol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Asiatic acid-loaded solid lipid microparticles stabilized with poloxamer-188 reduced porphyrin intensity, enhanced skin barriers, and improved skin hydration and brightness in fifteen participants with mild-to-moderate acne. ([International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

This ampoule is widely celebrated for repairing damaged skin barriers and soothing irritation, particularly for dry, sensitive, or mature skin types. Users consistently praise its rich, milky texture that provides deep hydration and a radiant glow without a sticky residue. However, it is often deemed too heavy for oily skin or humid weather. This summary is based on a very large amount of data and should be definitely taken into account.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Deeply moisturizing (often mentioned)
- Liked: Luxurious texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Too heavy (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Dropper issues (rarely noted)
- Disliked: Scent concerns (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SKIN1004 Probio-cica Intensive Ampoule a great fit for acne-prone skin?

This product is a great fit because fermented centella and centella extract calm blemishes and soothe irritation without clogging pores. Ceramide NP and panthenol further strengthen your skin barrier while keeping your face nicely hydrated.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this serum a good fit for acne-prone skin?

Lactobacillus Centella Asiatica Extract Ferment Filtrate and Centella Asiatica Extract make this serum a great fit because they offer strong calming action and barrier repair to soothe blemishes. Ceramide NP and polyhydroxystearic acid also help strengthen your skin barrier and add moisture without clogging pores.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Lactobacillus do for acne-prone skin?

Lactobacillus helps calm acne-prone skin by reducing pimples and redness while keeping irritation low compared to harsh treatments. It supports your skin barrier and brings a more balanced feel to areas prone to breakouts.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/), [Journal of Experimental Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39810881/)

### What does Centella Asiatica Extract do for acne-prone skin?

Centella asiatica extract helps calm angry skin, reduces redness, and supports healing for breakouts. It is unlikely to cause irritation and may improve overall skin clarity when used consistently.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine, as treatments with active ingredients are placed in the PM for simplicity and extra safety around sun exposure. It is unlikely to cause irritation and helps calm blemishes without clogging pores.

### Can I use it with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment after your retinol to help soothe any dryness or redness. The soothing ingredients help calm your skin while keeping pores clear, and using a gentle routine is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use it?

This treatment is great to use in the evening as part of your routine. It helps calm blemishes and repair your skin barrier without clogging pores, and is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts on acne-prone skin, thanks to soothing ingredients that calm blemishes and repair the skin barrier without heavy oils. It features a very safe formula with no harsh components, so negative reactions are rare.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

- Amazon.com: $19.04 (https://www.amazon.com/dp/B0CSDMNRGM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Polyhydroxystearic Acid, Betaine, Allantoin, Panthenol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin