# SKIN1004 Madagascar Centella Asiatica Ampoule for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SKIN1004](https://lovi.care/skincare/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Suitable for your normal skin due to Centella Asiatica Extract and Glycerin, which provide anti-inflammatory and humectant actions respectively, offering general soothing and hydration.
- While it addresses your normal skin type well, it lacks specialized ingredients to effectively target your concerns with wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Glycerin, Butylene Glycol, 1,2-Hexanediol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A preservative system containing 1,2-hexanediol and caprylyl glycol showed no delayed Type IV dermal sensitivity reactions in 200 subjects when tested as a 15% mixture in carbomer gel and in a cosmetic formulation. ([Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/))
- A topical cream containing 10% Bifidobacterium longum lysate significantly decreased skin sensitivity and increased skin resistance against physical and chemical aggression in female volunteers with reactive skin compared to a control cream. ([Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects. ([Journal of Ginseng Research, 2022](https://pubmed.ncbi.nlm.nih.gov/35509819/))
- Sensory skin irritation potential of 1,2-alkanediols increased with alkane chain length, whereas 1,2-hexanediol showed the lowest objective skin irritation potential compared to both shorter and longer chain lengths, and percutaneous absorption negatively correlated with alkane chain length. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21585401/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, users describe this ampoule as a gentle, watery product that effectively calms redness and repairs the moisture barrier without feeling heavy. It is highly praised by individuals with sensitive, acne-prone, or irritated skin. Some users with resilient skin types find it too lightweight for significant hydration or notice minimal changes.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Soothes redness (mostly mentioned)
- Liked: Safe for sensitive skin (often mentioned)
- Liked: Hydrating for oily skin (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Not hydrating enough (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SKIN1004 Centella Asiatica Ampoule work for mature skin?

This ampoule works well for everyday soothing and hydration, but mature skin needs a treatment that also targets fine lines and wrinkles with potent antioxidants, peptides, and skin-repairing ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for mature skin?

Centella Asiatica Extract and glycerin make this serum a good fit for your mature skin by providing soothing hydration and calming redness. However, because it lacks specialized ingredients to smooth wrinkles and fine lines, a treatment for mature skin needs potent antioxidants, peptides, and skin-repairing ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine, applied after cleansing and before moisturizing. It is very unlikely to cause irritation and helps calm and hydrate your skin, though mature skin also needs specialized ingredients like potent antioxidants or retinoids to smooth wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this soothing product first and following with your retinol to help calm your skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. To better care for mature skin, a product of this type needs firming and smoothing ingredients that target wrinkles and fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores on mature skin since it has a very safe profile with no harsh ingredients. To properly care for mature skin, a product of this type needs firming and smoothing ingredients that help reduce wrinkles and fine lines.
Sources: [Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — $810.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

- Amazon.com: $19.00 (https://www.amazon.com/dp/B06Y15D1LH?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Centella Asiatica Extract, Water, Glycerin, Butylene Glycol, 1,2-Hexanediol, Phenoxyethanol, Cellulose Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin
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- Netherlands: https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin