# SENTÉ Bio Complete Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/sente/bio-complete-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [SENTÉ](https://lovi.care/skincare/brands/sente)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your dry skin, as Glycerin and Sodium Hyaluronate provide humectant action to support hydration, while Retinol and Myristoyl Nonapeptide-3 effectively target fine lines and wrinkles.
- The formula includes Allantoin and Panthenol to soothe dry or flaky skin, though it lacks sufficient emollient ingredients for optimal hydration.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/sente/bio-complete-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/sente/bio-complete-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Retinol, Glycosaminoglycans, Heparan Sulfate, Niacinamide

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs. ([BMC Veterinary Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32197613/))
- Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling. ([International Journal of Molecular Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/29436595/))
- Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines. ([International Journal of Biological Macromolecules, 2017](https://pubmed.ncbi.nlm.nih.gov/28917941/))
- A topical eye cream containing low molecular weight heparan sulfate and naturally derived extracts improved periorbital hyperpigmentation, fine and coarse wrinkles, puffiness, and dark circles in 15 subjects over 12 weeks. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30636356/))
- Topical low molecular weight heparan sulfate improved periorbital discoloration and wrinkles starting at week two with continuous improvement up to week 12. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32562303/))
- Topical low molecular weight heparan sulfate improved skin hydration, firmness, elasticity, barrier function, and fine lines and wrinkles in 15 patients over 8 weeks. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151781/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## Why other serums fit dry skin better

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on limited data, this serum is highly praised for its anti-aging effects, improving skin texture and firmness while reducing fine lines. Some users experienced a greasy feel or slow results, and a negligible number mentioned the presence of fragrance.

- Liked: Gentle formula (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Anti-aging benefits (sometimes noted)
- Liked: Hydrating (sometimes noted)
- Disliked: Contains fragrance (rarely noted)
- Disliked: Greasy feel (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does SENTÉ Bio Complete Serum work for dry skin?

This serum works moderately well for dry skin, offering hydration through glycerin and sodium hyaluronate while targeting fine lines with retinol. It is unlikely to cause irritation and helps soothe dry patches with allantoin and panthenol, but it lacks enough softening ingredients for optimal moisture. A product for this skin needs rich hydrating ingredients, barrier support, and nourishing softeners to keep dry skin comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

This serum is an average fit for dry skin because ingredients like glycerin and sodium hyaluronate draw in moisture, while allantoin and panthenol help soothe dry patches. However, a product of this type needs richer nourishing oils, butters, or skin-repairing ceramides to lock in hydration and fully support dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Retinol do for dry skin?

Retinol is a poor fit for dry skin because it frequently causes scaling, stinging, and dryness. To care for dry skin properly, a product needs gentle, hydrating ingredients like ceramides, glycerin, and hyaluronic acid to lock in moisture and keep the skin barrier calm and smooth.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing. Because dry skin needs extra help, a product of this type works best for you when it also includes rich oils, rich butters, or other softening ingredients to lock in moisture.

### Can I use this serum with glycolic acid, and in what order?

You can use this serum with glycolic acid by applying the glycolic acid first, letting it absorb completely, and then applying this treatment. Because both ingredients can be strong, using them together may increase the likelihood of dryness or irritation on dry skin.

### How often should I use this serum?

This serum works well in an evening routine, starting gradually to help your skin adjust. Dry skin needs rich moisturizing ingredients like plant oils and butters or heavy creams to lock in hydration and prevent flakiness.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts on dry skin, and its safety profile is excellent with soothing components that help prevent irritation. However, it may cause mild purging when you first start using it due to the retinol.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — $16.75 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — $53.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — $19.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Dipropylene Glycol, Cyclopentasiloxane, Peg-12 Dimethicone Crosspolymer, Dimethicone Crosspolymer, Dimethicone Vinyl Dimethicone Crosspolymer, Dimethiconol, Dimethicone, Laureth-23, Laureth-4, Glycerin, Heparan Sulfate, Pentylene Glycol, Retinyl Safflowerate, Retinol, Lysophosphatidic Acid, Myristoyl Nonapeptide-3, Myristoyl Pentapeptide-17, Ethyl Safflowerate, Ethyl Flaxseedate, Dipalmitoyl Hydroxyproline, Allantoin, Panthenol, Sodium Hyaluronate, Sodium Ascorbyl Phosphate, Alanine, Arginine Hcl, Asparagine, Aspartic Acid, Cystine, Glutamic Acid, Glutamine, Histidine Hcl, Isoleucine, Leucine, Lysine Hcl, Acetyl Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine, Calcium Pantothenate, Folic Acid, Inositol, Niacinamide, Pyridoxal Hcl, Riboflavin, Thiamine Hcl, Calcium Chloride, Magnesium Sulfate, Potassium Chloride, Sodium Chloride, Sodium Phosphate, Beta-Carotene, Polysorbate 80, Polyaminopropyl Biguanide, Tromethamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sente/bio-complete-serum/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/sente/bio-complete-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/sente/bio-complete-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/sente/bio-complete-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/sente/bio-complete-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/sente/bio-complete-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/sente/bio-complete-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/sente/bio-complete-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/sente/bio-complete-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/sente/bio-complete-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/sente/bio-complete-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sente/bio-complete-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sente/bio-complete-serum/for/dry-skin