# Prequel Barrier Therapy Skin Protectant Cream for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Prequel](https://lovi.care/skincare/brands/prequel)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for dry skin.

## Why this fit

- Excellent for your dry skin, this product's oat and ceramides deeply hydrate and support your skin barrier, while shea butter provides emollient nourishment.
- The inclusion of allantoin further soothes and protects your dry or flaky skin, enhancing overall comfort and resilience.
- This formula is exceptionally safe for your skin, containing no harsh ingredients and featuring oat and allantoin to prevent irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Oat, Multi-Ceramides, Allantoin, Adenosine

## What the research says

- Application of Body Lotion for 5 weeks on cosmetic dry skin improved barrier properties, increased levels of cholesterol, ceramides, and long-chain fatty acids, increased beneficial skin bacteria, and enhanced microbiome functional potential compared to baseline. ([Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts. ([Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30519069/))
- Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model. ([Skin Pharmacology and Applied Skin Physiology, 2002](https://pubmed.ncbi.nlm.nih.gov/11867969/))
- Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607907/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

While the vast majority find it deeply hydrating and an excellent value for the size, a subset of users reported burning sensations or breakouts, and the product faced a significant recall in 2024 due to contamination concerns.

- Liked: Great value (often mentioned)
- Liked: Non-greasy texture (often mentioned)
- Liked: Versatile use (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Burning sensation (sometimes noted)
- Disliked: Recall history (sometimes noted)
- Disliked: Caused breakouts (rarely noted)

## Questions and answers

### What makes Prequel Barrier Therapy Skin Protectant Cream one of the best fits for dry skin?

This cream is one of the best fits for your dry skin because its oat and multi-ceramides deeply hydrate and support your skin barrier while shea butter provides smooth nourishment. Allantoin further calms and protects flaky skin to enhance your overall comfort and resilience.
Sources: [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Which ingredients make this cream a good fit for dry skin?

This cream is an exceptional fit for dry skin because its oat and multi-ceramides deeply hydrate and support your skin barrier, while shea butter provides rich nourishment. Additionally, allantoin and adenosine help soothe and protect flaky skin to enhance overall comfort.
Sources: [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### What does Oat do for dry skin?

Oat helps soothe and deeply moisturize dry skin by repairing the skin barrier and easing itch and roughness. It is unlikely to cause irritation and may significantly improve overall skin comfort.
Sources: [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27272074/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607907/)

### What do Ceramides do for dry skin?

Ceramides help keep dry skin soft by strengthening the outer barrier and locking in hydration. This improvement in barrier integrity reduces dryness and protects against irritation.
Sources: [The British Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34921679/), [Dermatologic Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/31585489/)

### Where does this cream go in a skincare routine for dry skin?

This cream goes as the moisturizer step in your morning routine and your evening routine. Using a moisturizer daily helps hydrate dry skin and supports your skin barrier.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the cream after your retinol treatment in the evening routine to help lock in moisture and soothe dryness. Using a barrier-supporting moisturizer helps improve skin comfort and reduces the irritation often caused by retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this cream daily as part of your morning and evening routine to keep dry skin hydrated and comfortable. Regular use of moisturizers with these ingredients helps improve skin barrier function and reduces dryness.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores or cause breakouts for dry skin, as its risk of causing breakouts is very low. Its rich blend of oat, multi-ceramides, and shea butter deeply hydrates and nourishes your skin without heavy oils.
Sources: [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon
- [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/dry-skin) — Superior fit — $85.00 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-skin) — Superior fit — $12.50 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — $22.00 at Amazon

## Where to buy

- Amazon.com: $35.98 (https://www.amazon.com/dp/B0GR75MHZ2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Oat, Water, Carthamus Tinctorius Seed Oil, Cetyl Alcohol, Glycerin, Butyrospermum Parkii Butter, Caprylic Capric Triglyceride, Dimethicone, C10-18 Triglycerides, Allantoin, Adenosine, Cetearyl Olivate, Sorbitan Olivate, Ceramide Ap, Ceramide Eos, Ceramide Eop, Ceramide Np, Ceramide Ns, Cholesterol, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Glycolipids, Sodium Stearoyl Glutamate, Behenic Acid, Ceteareth-25, Glycine Soja Sterols, Hydrogenated Palm Glycerides, Hydrogenated Palm Glycerides Kernel, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Tocopheryl Acetate, Tetrasodium Glutamate Diacetate, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- France: https://lovi.care/skincare/fr/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/prequel/barrier-therapy-skin-protectant-cream/for/dry-skin