# Pharma Développement A313 Vitamin A Retinol Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Pharma Développement](https://lovi.care/skincare/brands/pharma-developpement)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin due to the presence of multiple forms of retinol, which help reduce the appearance of fine lines and wrinkles.
- While the retinol forms provide mild retinoid activity, the formula lacks sufficient humectants and emollients to fully support hydration and barrier function for your skin.
- The product is safe for your normal skin, as it does not contain any harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinyl Palmitate, Retinyl Acetate, Retinyl Propionate, Peg-4000, Polysorbate 80

## What the research says

- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate. ([Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/))
- A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical retinyl propionate cream produced no statistically significant differences compared to placebo for any clinical, histological, or profilometric parameters of skin photoageing in 80 subjects. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9894360/))
- Topical application of 20% 2-hydroxypropyl-beta-cyclodextrin in a polyethylene glycol formulation resulted in significantly more herpes labialis relapses compared to the vehicle control among 40 patients over 6 months. ([Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23816977/))
- Binary systems of trans-resveratrol with polyethylene glycol or beta-cyclodextrin enhanced its antioxidant activity and in vivo skin anti-aging effects compared to trans-resveratrol alone in human keratinocytes and volunteers. ([Drug Development and Industrial Pharmacy, 2014](https://pubmed.ncbi.nlm.nih.gov/23862976/))
- Topical application of 30% salicylic acid in polyethylene glycol effectively cleared comedones and papules in 436 patients with acne while causing no stinging, burning, edema, bleeding, or crusting. ([Dermatologic Surgery, 2008](https://pubmed.ncbi.nlm.nih.gov/18363720/))
- Hempseed or flaxseed oil-based lyotropic liquid crystals with the highest oil content and lecithin/Tween 80 mixture provided a 2-fold reduction in TEWL values and decreased skin erythema levels in healthy adult subjects compared to baseline. ([Acta Pharmaceutica, 2024](https://pubmed.ncbi.nlm.nih.gov/38815204/))
- Liquid crystalline emulsions formulated with camellia seed oil and four different surfactant combinations reduced transepidermal water loss and increased skin hydration without causing skin irritation, with the formulation containing Lecinol S-10 and Tween 80 demonstrating the best clinical results. ([Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/36918671/))
- The cytotoxic effect of sodium lauryl sulphate on normal human keratinocytes was significantly decreased when combined with cocamidopropyl betaine, Tween 20, and Tween 80 at concentrations well below the critical micelle concentration. ([Skin Pharmacology and Applied Skin Physiology, 2003](https://pubmed.ncbi.nlm.nih.gov/12677096/))

## What reviewers say

Based on a very large amount of data, this French pharmacy favorite is celebrated for delivering radiant, smooth skin and reducing acne, with users frequently waking up to a glowing complexion. However, its thick, Vaseline-like consistency and initial itching are polarizing aspects. While many praise its hydrating and plumping effects, some find it too mild for significant anti-aging results.

- Liked: Incredible glow (mostly mentioned)
- Disliked: Intense itching (mostly mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: Greasy texture (often mentioned)
- Liked: Acne reduction (sometimes noted)
- Liked: Affordable price (sometimes noted)
- Liked: Occlusive hydration (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Application difficulty (rarely noted)
- Disliked: Pore clogging (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does A313 Retinol Cream work for mature skin?

Pharma Développement A313 Vitamin A Retinol Cream is an average fit for mature skin, offering moderate anti-aging benefits and helping reduce the appearance of fine lines and wrinkles. However, it lacks sufficient hydrating and softening ingredients to fully support your skin barrier, so mature skin of this type needs added nourishing oils, peptides, and strong moisturizers.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### Which ingredients make this cream a good fit for mature skin?

Retinyl Palmitate, Retinyl Acetate, and Retinyl Propionate make this cream a good fit because they help smooth out fine lines and wrinkles. However, a product for this skin also needs nourishing oils, peptides, and extra moisturizing ingredients to fully support hydration and barrier function.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### What does Retinyl Palmitate do for mature skin?

Retinyl palmitate helps smooth out fine lines and wrinkles on mature skin while improving overall firmness, texture, and dryness. It may also help protect against sun-induced aging by supporting skin structure and reducing collagen breakdown.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

### What does Retinyl Acetate do for mature skin?

Retinyl acetate helps mature skin by smoothing fine lines and keeping it soft. It may help boost collagen to make dry or aging skin feel firmer and look healthier over time.
Sources: [Archives of Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17515510/), [The Journal of Investigative Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/10692106/)

### Where does this cream go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. A product of this type needs enough hydrating and softening ingredients to fully support mature skin.

### Can I use this cream with niacinamide, and in what order?

Yes, you can use this cream with niacinamide by applying niacinamide in your hydrating toner or serum before this treatment. Pairing them helps smooth fine lines while minimizing potential discomfort from the retinol forms.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### How often should I use this cream?

You can use this treatment in your evening routine, starting slowly to see how your skin reacts. To work best for mature skin, a product of this type needs enough hydrating ingredients and softening agents to support moisture and skin barrier function.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause purging since its retinol forms work gently, but it has a greasy texture that may clog pores on some skin. Mature skin generally needs formulas with rich moisturizers and hydrating ingredients to stay balanced when using vitamin A treatments.
Sources: [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — $76.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

- Amazon.com: $47.20 (https://www.amazon.com/dp/B085BW1BZX?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Retinyl Acetate, Retinyl Propionate, Retinyl Palmitate, Peg-4000, Peg 400, Polysorbate 80
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/pharma-developpement/a313-vitamin-a-retinol-cream/for/mature-skin