# Perricone MD Rejuvenating Moisturizer for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Perricone MD](https://lovi.care/skincare/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your combination skin, with glycerin and dimethicone providing hydration and smoothing, but it lacks specialized ingredients to effectively address oily shine.
- Tetrahexyldecyl ascorbate offers antioxidant benefits, while lactic acid can help with texture, though these may not fully balance the needs of both oily and dry areas.
- The product is generally safe for your combination skin, with minimal risks of irritation from lactic acid and parfum.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Tetrahexyldecyl Ascorbate, Ribose, Lactic Acid, Macadamia Ternifolia Seed Oil

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Petrolatum-based skin protectants demonstrated protection against irritants and maceration while providing skin hydration, whereas dimethicone and zinc oxide products showed varying or limited performance across parameters among 18 healthy volunteers compared to positive and negative controls. ([Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/))
- Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate. ([European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))

## What reviewers say

This moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.

- Liked: Deeply hydrating (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Non-greasy formula (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Product pilling (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)
- Disliked: White cast (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Rejuvenating Moisturizer work for combination skin?

This moisturizer works reasonably well for combination skin by providing moderate hydration and smoothing, though it lacks specialized ingredients to effectively control oily shine in the T-zone. Combination skin of this type needs balanced formulas containing targeted brightening agents and oil-controlling ingredients to manage both dry and oily areas without causing heaviness or irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

Glycerin and dimethicone help hydrate and smooth your skin, while tetrahexyldecyl ascorbate provides antioxidants. However, because this product lacks specialized ingredients to control oily shine, combination skin needs a treatment with ingredients that target both oil control and balanced hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/)

### What does Acyl-Glutathione do for combination skin?

Acyl-Glutathione helps brighten skin color and smooth out wrinkles while keeping combination skin hydrated. Topical use of glutathione may improve dark spots and reduce water loss, though its overall effect can vary from person to person.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30895708/)

### What does Vitamin C do for combination skin?

Vitamin C helps brighten combination skin, smooth out uneven texture, and protect against daily environmental stress while keeping it balanced. It may also improve hydration and reduce redness in areas that tend to be dry or irritated.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38525606/), [Photochemistry and Photobiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33529350/)

### Where does it go in a skincare routine for combination skin?

This moisturizer goes in the morning routine after your hydrating toner and SPF, and in the evening routine as the final step. A product of this type for combination skin needs ingredients that provide balanced hydration and help manage oily shine.

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first and following it with this moisturizer to help keep your skin comfortable and smooth. Combination skin requires a moisturizer that balances dry patches while managing oily shine.

### How often should I use it?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps improve skin moisture, smoothness, and overall texture while keeping your skin barrier supported.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts on combination skin, though it may not fully control oily shine. A product for this skin needs lightweight hydration and balancing ingredients that manage both dry patches and excess oil without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Ostomy/wound Management, 2005](https://pubmed.ncbi.nlm.nih.gov/16439809/)

### Can I use it around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as its safety profile supports general application. However, a product of this type needs lighter hydration and oil-balancing ingredients to properly care for thin eye skin and varied body areas.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — $15.50 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — $49.95 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — $12.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — $14.97 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rejuvenating-moisturizer/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rejuvenating-moisturizer/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rejuvenating-moisturizer/for/combination-skin