# Perricone MD Rebalancing Elixir for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Perricone MD](https://lovi.care/skincare/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Highly suitable for normal skin, this formula utilizes capryloyl glycine and sodium bicarbonate to effectively mattify and cleanse pores, addressing your oily skin concerns.
- Glycerin and Sodium PCA provide essential hydration, while Annona Cherimola Fruit Extract offers antioxidant benefits, supporting your goal of reducing wrinkles and fine lines.
- The product is safe for your normal skin, featuring soothing ingredients like Cannabidiol and mushroom extracts that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/oily-acne-prone-skin): High

## Key ingredients

Cannabidiol, Mushroom Complex, Cherimoya Fruit Extract, Capryloyl Glycine, Sodium Pca

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of an anti-aging gel containing EPA and CBD reduced inflammatory agents, decreased crow's feet and fine line wrinkle volume, reduced the subepidermal low-echogenic band by 8.8%, and increased skin hydration by 31.2% and elasticity by 25.6% in 33 participants over 56 days compared to baseline. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/))
- Topical nano-cannabidiol cream reduced UV-A-induced epidermal hyperplasia, nuclear DNA base lesions, and mitochondrial DNA deletions compared with vehicle in nineteen participants. ([Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39025264/))
- Daily application of a novel retinol and cannabidiol combination topical improved global skin quality across 13 domains, including visible pores, dehydration, surface roughness, and static and dynamic wrinkles, in 10 patients with facial skin imperfections. ([Aesthetic Surgery Journal. Open Forum, 2022](https://pubmed.ncbi.nlm.nih.gov/35274096/))
- Topical application of carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol reduced inflammation and increased collagen production in radiation-combined wound skin injury in mice. ([Phytomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40318533/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of a formulation containing capryloyl glycine 4% significantly decreased hair density, median hair length, and terminal hair density on the forearms compared to placebo in female patients with hypertrichosis after 120 days. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33347705/))
- A novel natural carrier-free assembled gel composed of sodium pyrrolidone carboxylate and baicalin alleviates UVB-induced skin photodamage by scavenging reactive oxygen species, protecting mitochondria, restoring oxidative homeostasis, inhibiting inflammatory responses, and regulating collagen-related proteins. ([Biomaterials Advances, 2026](https://pubmed.ncbi.nlm.nih.gov/41129958/))

## What reviewers say

Most users find it provides lightweight hydration that absorbs quickly without feeling heavy, leading to improved skin balance and texture. A moderate number of users feel the product is too expensive for the results, and a low number dislike the natural scent or do not see dramatic anti-aging effects.

- Liked: Soothes sensitive skin (mostly mentioned)
- Liked: Lightweight hydration (often mentioned)
- Liked: Good for layering (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Expensive for results (sometimes noted)
- Disliked: Not a miracle worker (rarely noted)
- Disliked: Product availability issues (rarely noted)
- Disliked: Unpleasant natural scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Rebalancing Elixir a great fit for mature skin?

Perricone MD Rebalancing Elixir is a great fit for mature skin because glycerin and sodium PCA provide essential hydration while cherimoya fruit extract offers antioxidant benefits to help reduce wrinkles and fine lines. Additionally, soothing ingredients like cannabidiol and mushroom extracts help minimize irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this elixir a good fit for mature skin?

Glycerin and Sodium PCA help smooth and hydrate mature skin, while Annona Cherimola Fruit Extract provides antioxidants that reduce wrinkles and fine lines. Cannabidiol and mushroom extracts further support this skin type by soothing irritation and improving overall elasticity.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Cannabidiol do for mature skin?

Cannabidiol helps mature skin by increasing hydration and elasticity while smoothing out fine lines and crow's feet. It also helps calm irritation and protects against UV-related damage.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/), [Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39025264/)

### What does Mushroom Complex do for mature skin?

Mushroom Complex helps mature skin stay soft and smooth by fighting the daily oxidative stress that leads to wrinkles. It also may support firmness by promoting collagen production and keeping your skin looking calm and healthy.
Sources: [Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40057933/), [Gels, 2025](https://pubmed.ncbi.nlm.nih.gov/39852004/)

### Where does this elixir go in a skincare routine for mature skin?

This elixir goes in your evening routine as a treatment step after cleansing and toning, and before your moisturizer. Putting it in the evening helps keep your skin safe from sun exposure while working on fine lines.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol product. The soothing ingredients in this formula help calm the skin and reduce irritation when using strong active ingredients.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use it?

Perricone MD Rebalancing Elixir is designed for evening use in your mature skin routine, applied after cleansing and before moisturizing. Starting with evening use is ideal for simplicity and extra safety around sun exposure, and this formula helps hydrate your skin while reducing wrinkles and fine lines.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for mature skin?

Perricone MD Rebalancing Elixir is unlikely to clog pores or cause breakouts for mature skin because it features ingredients that clean out pores and soothe the skin, keeping irritation low. Glycerin and sodium PCA help keep your skin hydrated without heavy oils, while soothing ingredients like cannabidiol and mushroom extracts help calm the skin.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37264742/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — $76.00 at Amazon
- [SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin) — High fit — $19.04 at Amazon
- [Aestura A-Cica 365 Blemish Calming Serum](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/mature-skin) — High fit — $38.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

- Amazon.com: $99.00 (https://www.amazon.com/dp/B0G6HLB48Z?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, 1,2-Hexanediol, Sodium Pca, Triethyl Citrate, Propanediol, Capryloyl Glycine, Glycerin, Annona Cherimola Fruit Extract, Cannabidiol, Ganoderma Lucidum Stem Extract Mushroom Stem Extract, Grifola Frondosa Fruiting Body Extract, Sodium Bicarbonate, Caprylhydroxamic Acid, Sodium Hydroxide, Citric Acid, Cannabis Sativa Glycereth-8 Esters Seed Oil, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Citrate, Lentinus Edodes Mycelium Extract, Sodium Dehydroacetate, Phenylpropanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/rebalancing-elixir/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/rebalancing-elixir/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/rebalancing-elixir/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/rebalancing-elixir/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/rebalancing-elixir/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/rebalancing-elixir/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/rebalancing-elixir/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/rebalancing-elixir/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/rebalancing-elixir/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/rebalancing-elixir/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/rebalancing-elixir/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/rebalancing-elixir/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/rebalancing-elixir/for/mature-skin