# Perricone MD Nutritive Cleanser for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Perricone MD](https://lovi.care/skincare/brands/perricone-md)
Category: [Cleansers](https://lovi.care/skincare/best/cleansers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other cleansers fit it better.

## Why this fit

- Offers moderate cleansing for your normal skin due to lauryl glucoside and cocamidopropyl betaine, which effectively remove impurities without stripping the skin.
- While Dimethyl Mea Dmae and Alpha-Lipoic Acid provide antioxidant benefits, they are not present in concentrations sufficient to significantly target your wrinkles and fine lines.
- The product is safe for your normal skin, as it lacks prohibited or harsh ingredients and poses no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/oily-acne-prone-skin): Average

## Key ingredients

Alpha Lipoic Acid, Copper Gluconate, Zinc Gluconate, Dimethyl Mea Dmae, Aha Complex

## What the research says

- Topical 30% P407 gel loaded with ALA cubosomes reduced facial lines, nearly resolved fine lines in the periorbital and upper lip areas, and improved skin color and texture without irritation or peeling in volunteers. ([European Journal of Pharmaceutics and Biopharmaceutics, 2014](https://pubmed.ncbi.nlm.nih.gov/24056055/))
- Application of 5% cubosomal alpha lipoic acid gel twice daily for 6 months significantly improved global aesthetic scores and increased epidermal thickness compared to placebo in 20 aging female faces. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/27873449/))
- Treatment with a cream containing 5% alpha-lipoic acid for 12 weeks reduces skin roughness by an average of 50.8% compared to 40.7% with placebo in women with photoaged facial skin. ([The British Journal of Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14616378/))
- Zinc gluconate induced alpha2, alpha3, alphaV, and alpha6 integrins, copper gluconate induced alpha2, alpha6, and beta1, and manganese gluconate induced most studied integrins in cultured keratinocytes. ([The British Journal of Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10215764/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))

## Why other cleansers fit mature skin better

- Transgenic cucumber expressing poly-γ-glutamic acid synthesis genes increased water content by 6-14%, reduced water loss by 11-12%, decreased facial wrinkles and roughness by 19.58% and 24.97%, decreased skin melanin by 5.27%, and improved facial elasticity in human skin and zebrafish compared to controls. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38336313/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Camellia japonica oil activated the human COL1A2 promoter, induced type I procollagen synthesis, inhibited matrix metalloproteinase-1 activity, and reduced trans-epidermal water loss without inducing adverse reactions in human skin. ([Journal of Ethnopharmacology, 2007](https://pubmed.ncbi.nlm.nih.gov/17386986/))

## What reviewers say

Based on a very large amount of data, users frequently praise this gel cleanser for its ability to thoroughly remove makeup and oil without stripping the skin's natural moisture barrier, making it a favorite for those with normal to dry skin. Many report softer, brighter, and more radiant skin after use, though a notable minority of users express dissatisfaction with the product's strong fragrance and the recent packaging change from a glass bottle to a plastic tube.

- Liked: Gentle and non-drying (mostly mentioned)
- Liked: Effective makeup remover (often mentioned)
- Liked: Anti-aging benefits (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Eye irritation (rarely noted)
- Disliked: High price point (rarely noted)

## How to apply

- Use your cleanser as part of both your AM and PM routine. Start using it daily since your skin is normal and not sensitive.
- Apply this first in your routine before using your toner, moisturizer, and SPF.
- Gently massage the cleanser onto your face using circular motions, then rinse well with water. Avoid rubbing your skin too hard.
- Apply the cleanser directly onto slightly damp skin for the best fresh feeling. Make sure your face is clean of heavy makeup first.
- Avoid the sensitive eye area while washing. Do a quick patch test before your very first use to be safe.
- Video: https://storage.pora.ai/6a08416bd9315041c09c72f61cf27cc1.mp4

## Questions and answers

### How well does Perricone MD Nutritive Cleanser work for mature skin?

This cleanser works moderately well for mature skin because it gently removes impurities without drying, though its antioxidant ingredients are not present in high enough amounts to significantly target wrinkles and fine lines. A cleanser for mature skin needs hydrating and soothing ingredients like amino acids and aloe, along with specialized active ingredients to better target lines and keep the skin soft and smooth.
Sources: [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24617572/)

### Which ingredients make this cleanser a good fit for mature skin?

This cleanser is a moderate fit for mature skin because it contains lauryl glucoside and cocamidopropyl betaine to gently wash away impurities without leaving your skin feeling dry. While it includes helpful antioxidants like Alpha Lipoic Acid and Dimethyl Mea Dmae, a cleanser for mature skin ideally needs hydrating and soothing ingredients like amino acids and aloe to truly soften fine lines and keep the skin smooth.
Sources: [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24617572/)

### What does Alpha Lipoic Acid do for mature skin?

Alpha-lipoic acid helps smooth out lines, reduce rough patches, and improve overall skin texture for mature skin. It may also help improve skin color and aesthetic scores without causing irritation or peeling.
Sources: [The British Journal of Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14616378/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/27873449/)

### What does Copper Gluconate do for mature skin?

Copper Gluconate helps keep mature skin firm and smooth by supporting the natural building blocks that give skin its bounce. It is unlikely to cause irritation and works well to keep your face looking fresh and resilient.

### Where does this cleanser go in a skincare routine for mature skin?

Use this cleanser in the morning and evening as part of your daily routine for mature skin. It effectively removes impurities without stripping your skin, though a cleanser for mature skin also needs ingredients that significantly target wrinkles and fine lines.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use it with retinol, and in what order?

You can use this cleanser before applying retinol, as it washes away impurities gently without irritating your skin. Mature skin using retinol needs a cleanser that also adds nourishing and hydrating ingredients to help keep the skin soft and smooth.
Sources: [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24617572/)

### How often should I use this cleanser?

You can use this cleanser daily in the morning and evening as part of your routine. Using a mild cleanser helps keep skin clean without drying it out, and it is safe for regular use.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24617572/)

### Can this cleanser clog pores, cause breakouts or purging for mature skin?

This cleanser is unlikely to clog pores, cause breakouts, or lead to purging on mature skin. It uses gentle cleansers that lift away dirt without leaving a heavy film behind, and a product for this skin needs nourishing ingredients like peptides and antioxidants to help keep it smooth and firm.
Sources: [International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24617572/)

### Can I use it around the eyes or on my body?

You can use this cleanser on your body, but you should avoid using it directly around your eyes because the skin in that area is much thinner and more easily irritated. Mature skin needs a cleanser that is very gentle and free of strong cleansing agents to prevent dryness on the body, while the eye area requires specialized moisturizing ingredients that target fine lines.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cleanser fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for mature skin

- [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- [Missha Super Aqua Ultra Hyalron Cleansing Foam](https://lovi.care/skincare/p/missha/super-aqua-ultra-hyalron-cleansing-foam/for/mature-skin) — High fit — $9.20 at Amazon
- [Pyunkang Yul Calming Low pH Foaming Cleanser](https://lovi.care/skincare/p/pyunkang-yul/calming-low-ph-foaming-cleanser/for/mature-skin) — High fit — $15.99 at Amazon

## Pairs well with

- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

- Amazon.com: $39.00 (https://www.amazon.com/dp/B084RSMQ45?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Sodium Laureth Sulfate, Lauryl Glucoside, Cocamidopropyl Betaine, Ppg-2 Hydroxyethyl Coco Isostearamide, Dimethyl Mea Dmae, Citric Acid, Sodium Chloride, Thioctic Acid Alpha-Lipoic Acid, Disodium Edta, Parfum, Benzophenone-4, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Methylchloroisothiazolinone, Methylisothiazolinone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/nutritive-cleanser/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/nutritive-cleanser/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/nutritive-cleanser/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/nutritive-cleanser/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/nutritive-cleanser/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/nutritive-cleanser/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/nutritive-cleanser/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/nutritive-cleanser/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/nutritive-cleanser/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/nutritive-cleanser/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/nutritive-cleanser/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/nutritive-cleanser/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/nutritive-cleanser/for/mature-skin