# Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Perricone MD](https://lovi.care/skincare/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for oily skin.

## Why this fit

- Highly suitable for your oily skin, this serum effectively controls shine with niacinamide and provides excellent hydration through sodium hyaluronate crosspolymer and sodium hyaluronate, addressing your primary concern. The inclusion of dimethicone further enhances the matte finish, ensuring your oily shine is managed throughout the day. The product boasts a strong safety profile, with soothing ingredients like glycerin and niacinamide, and lacks harsh components, making it non-irritating for your oily skin.
- Acetyl glucosamine and dimethicone work synergistically to refine skin texture and provide a smooth, matte appearance, complementing the hydrating benefits for your oily skin.
- The formulation is safe for your skin, featuring gentle ingredients and avoiding any known irritants, ensuring a comfortable and non-reactive experience.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Ceramide Np, Acetyl Glucosamine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))

## What reviewers say

Users consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.

- Liked: Deep hydration (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Plumps fine lines (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine every day to keep your face fresh.
- Apply this moisturizer after cleansing and toning, but right before your SPF in the morning.
- Gently press a small amount into your skin and let it absorb fully.
- Apply on clean, slightly dry skin to help control that oily shine.
- Avoid the eye area and do a quick patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Hyaluronic Intensive Hydrating Serum a great fit for oily skin?

This serum is a great fit because it controls shine with niacinamide and dimethicone while delivering deep hydration through sodium hyaluronate. It has a gentle, non-irritating formula with soothing ingredients like glycerin that helps keep oily skin comfortable and smooth without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for oily skin?

This serum is a great fit because sodium hyaluronate and sodium hyaluronate crosspolymer deliver deep hydration without extra weight, while niacinamide and dimethicone help control shine for a smooth, matte finish. These gentle ingredients are unlikely to cause irritation and keep oily skin feeling comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Hyaluronic Acid do for oily skin?

Hyaluronic acid helps oily skin by reducing extra oil and sebum production without causing irritation. Clinical studies show it successfully balances oil levels while keeping the skin comfortable.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your oily skin hydrated while managing shine. Using a gentle hydrating serum alongside retinol helps keep your skin calm and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum fits well in your evening routine for simplicity and extra safety around sun exposure, though it can also be used in the morning or twice a day. Daily application helps maintain hydration and manage oily shine while remaining gentle on your skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on oily skin. It features a lightweight formula with niacinamide and dimethicone that helps manage shine while remaining gentle and non-irritating.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes, though the skin there is very thin, because it has a gentle formula with soothing ingredients that are unlikely to cause irritation. While it works well for the face, using it on the entire body can be costly due to the small bottle size.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-skin) — High fit — $8.40 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/p/isntree/green-tea-fresh-serum/for/oily-skin) — High fit — $17.90 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/oily-skin) — High fit — $30.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — $15.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — $14.97 at Amazon

## Where to buy

- Amazon.com: $135.00 (https://www.amazon.com/dp/B09WZT5N7X?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin