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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for combination skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for combination skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate moisturizing for your combination skin, with glycerin and S-palmitoylglutathione providing hydration and smoothing texture, though it may not fully address oiliness in your T-zone.
  • The formula provides general skincare benefits and antioxidant activity from ingredients like Palmitoyl Glycine and Tetrahexyldecyl Ascorbate, supporting collagen synthesis.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
  • Apply this moisturizer after your cleanser and toner, right before your morning SPF.
  • Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
  • Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
  • Avoid the eye area when applying the moisturizer. Do a patch test before your first use.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

How well does Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer work for combination skin?

This moisturizer works moderately well for combination skin, providing decent hydration and smoothing texture with glycerin and acyl-glutathione, though it may not fully control shine in your T-zone. A product for this skin needs effective brightening and moisturizing ingredients that reduce oily shine without causing irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for combination skin?

Glycerin and S-palmitoylglutathione help hydrate and smooth combination skin. To work best for this skin type, a product of this type needs effective brightening and moisturizing ingredients that reduce oily shine without irritation, along with soothing agents and antioxidants.

Clinical, Cosmetic and Investigational Dermatology, 2017International Journal of Cosmetic Science, 2010

What does Acyl-Glutathione do for combination skin?

Acyl-Glutathione helps brighten skin color and smooth out wrinkles while keeping combination skin hydrated. Topical use of glutathione may improve dark spots and reduce water loss, though its overall effect can vary from person to person.

The Journal of Clinical and Aesthetic Dermatology, 2025Journal of Cosmetic Dermatology, 2019

What does Vitamin C do for combination skin?

Vitamin C helps brighten combination skin, smooth out uneven texture, and protect against daily environmental stress while keeping it balanced. It may also improve hydration and reduce redness in areas that tend to be dry or irritated.

Journal of Cosmetic Dermatology, 2024

Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment goes after your hydrating toner and before your SPF in the morning, and as the final step in the evening. This type of product needs lightweight hydration and ingredients that balance oil to fully address the needs of combination skin.

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying your retinol first, letting it dry, and then smoothing on this moisturizer. Using a moisturizing cream like this helps keep your skin comfortable and supports your skin barrier while you use stronger treatments.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular application helps keep your skin soft while providing antioxidant benefits, though combination skin also needs lightweight hydrators and oil-controlling ingredients to properly balance the T-zone.

Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015

Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to cause irritation or breakouts on combination skin because it avoids harsh ingredients, though its richer oils may not fully manage oiliness in your T-zone. A moisturizer for this skin needs lighter hydrators and oil-balancing ingredients to keep the T-zone fresh while softening dry areas.

Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream around the eyes or on my body?

This cream is safe to use on the delicate skin around the eyes and on the body because it lacks harsh ingredients and has a very good safety profile. For best results on thin areas like the eyelids, a product of this type needs lightweight hydrators and gentle nourishing oils that smooth and protect without feeling heavy.

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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