Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer for dry skin
Acyl-Glutathione
Niacinamide
Shea Butter
Lactic Acid
Vitamin F BlendHigh
- SuperiorDry Skin Fit
- AverageEffectiveness
- ExcellentSafety
A great choice for dry skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your dry skin is provided by shea butter and macadamia ternifolia seed oil, which offer emollient action and barrier repair, complementing the hydrating and barrier-resilient benefits of niacinamide.
- The formula's inclusion of sunflower seed oil and rosemary leaf extract further supports skin health and provides antioxidant protection.
- The product is safe for your dry skin, as it contains no harsh ingredients and includes soothing components like shea butter and sunflower seed oil.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
Questions and answers
What makes Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer a great fit for dry skin?
This moisturizer is a great fit for dry skin because shea butter and macadamia seed oil deeply soften and repair your skin barrier, while niacinamide helps keep it hydrated and strong. It is safe for your skin type with no harsh ingredients and includes soothing components like sunflower seed oil.
Which ingredients make this cream a good fit for dry skin?
Shea butter and macadamia seed oil make this cream a great fit for dry skin by softening and helping repair the skin barrier, while niacinamide adds extra hydration. These ingredients work safely together without harsh components, helping keep dry skin calm and comfortable.
What does Acyl-Glutathione do for dry skin?
Acyl-glutathione helps protect dry skin by boosting antioxidant defenses and supporting moisture levels. It is unlikely to irritate dry skin and may help keep it feeling soft and smooth.
What does Niacinamide do for dry skin?
Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Journal of Cosmetic Dermatology, 2004Journal of Cosmetic Dermatology, 2026
Where does it go in a skincare routine for dry skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. Using a consistent daily skincare routine with a moisturizer helps significantly improve visual dryness and overall skin comfort.
Can I use this cream with retinol, and in what order?
You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer at night. Using a barrier-supporting moisturizer like this helps keep dry skin calm and reduces the irritation that retinol often causes.
How often should I use it?
This moisturizing treatment is designed for evening use as part of your nightly routine to repair and hydrate your dry skin. Applying it daily helps improve skin moisture, texture, and overall barrier strength without causing irritation.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for dry skin?
This cream is unlikely to clog pores or cause breakouts for dry skin because it contains no harsh ingredients and features soothing components like shea butter and sunflower seed oil. The formula has excellent suitability for dry skin, helping to keep it calm and comfortable.
Can I use it around the eyes or on my body?
This moisturizing treatment is well-suited for the body and the thin skin around the eyes because its nourishing ingredients help protect dry skin without causing irritation. It is safe for delicate areas and supports skin health with soothing components and antioxidants.
Surgical and Radiologic Anatomy, 2002Lasers in Medical Science, 2025
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool).
What the research says
A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.
Cutis, 2004Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.
Journal of the American Academy of Dermatology, 1992A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.
The Journal of Clinical and Aesthetic Dermatology, 2020Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites.
Clinical and Experimental Dermatology, 1998Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face.
The Journal of Clinical and Aesthetic Dermatology, 2017Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin.
Biological & Pharmaceutical Bulletin, 2004
Ingredients
Water, Butyrospermum Parkii Butter Shea Butter, Myristyl Myristate, Niacinamide, C12-15 Alkyl Benzoate, Stearic Acid, Dimethicone, Sodium Acrylates Copolymer, Palmitoyl Glycine, S-Palmitoylglutathione, Ethylhexylglycerin, Myristyl Laurate, Ribose, Lecithin, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Salvia Hispanica Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Glyceryl Stearate, Peg-100 Stearate, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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