# Perricone MD Cold Plasma Plus+ Sub-D/Neck for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Perricone MD](https://lovi.care/skincare/brands/perricone-md)
Category: [Sunscreens and SPF moisturizers](https://lovi.care/skincare/best/sunscreens)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few sunscreens fit it even better.

## Why this fit

- Offers excellent moisturizing for your combination skin, as glycerin and dimethicone provide hydration and smoothness, while niacinamide helps control oil and offers antioxidant benefits.
- Bisabolol further supports skin comfort by soothing potential irritation, ensuring a gentle yet effective experience.
- The product is safe for your skin, containing no harsh ingredients and including beneficial components for overall skin health.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-acne-prone-skin): High

## Key ingredients

Dmae, Niacinamide, Tetrahexyldecyl Ascorbate, Acetyl Tetrapeptide-9, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users frequently report visible improvements in skin texture and firmness along the jawline and neck, describing the skin as smoother and more hydrated. A significant number of reviewers consistently complain about a strong, unpleasant scent often compared to pickles or fish, and some experience issues with the product pilling under makeup.

- Disliked: Unpleasant smell (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Visibly tightens and firms (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Lightweight and absorbent (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Pilling or flaking (rarely noted)

## How to apply

- Apply this moisturizing sunscreen AM daily to protect your skin and control shine. Reapply as needed throughout the day.
- Use it as the final step of your morning routine after applying your moisturizer. It combines hydration and sun protection in one.
- Gently smooth a nickel-sized amount evenly over your face, avoiding harsh rubbing. Let it absorb fully before putting on makeup.
- Apply it directly to clean, dry skin for the best oil-controlling finish. Ensure your face is completely dry so the product sets properly.
- Avoid the immediate eye area during application. Do a patch test before your first use to check for any sensitivity.
- Video: https://storage.pora.ai/53e9a436d82fca2a189dd08aa21de2fd.mp4

## Questions and answers

### What makes Perricone MD Sub-D/Neck a great fit for combination skin?

This product is a great fit because glycerin and dimethicone bring hydration and smoothness to your combination skin, while niacinamide helps control oil. Bisabolol also calms potential irritation, keeping the skin comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit because glycerin and dimethicone bring much-needed hydration and smoothness, while niacinamide helps control oil. Additionally, bisabolol soothes potential irritation to keep your skin comfortable and balanced.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does DMAE do for combination skin?

DMAE helps firm combination skin and smooth out fine lines when used daily, though a product of this type needs added hydrating ingredients to keep dry areas soft while balancing oilier zones.
Sources: [American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/), [Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizing spf goes in the morning routine after your hydrating toner and before your sunscreen step. It provides hydration and smoothness while helping control oil, making it a great fit for your skin type.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer. This helps keep your combination skin smooth and hydrated while minimizing potential dryness or irritation from the retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing spf is a great fit for your combination skin, providing deep hydration and smoothness while helping control oil and soothe potential irritation. Daily use helps maintain skin health and moisture without harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, as it has a safe formula with gentle ingredients that keep your skin calm and balanced. It provides great hydration and smoothness while helping to control oil without harsh additives.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for combination skin

- [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/p/purito/daily-soft-touch-sunscreen/for/combination-skin) — High fit — $15.90 at Amazon
- [innisfree Daily Sensitive Sunscreen](https://lovi.care/skincare/p/innisfree/daily-sensitive-sunscreen/for/combination-skin) — Average fit — $30.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $135.00 (https://www.amazon.com/dp/B0CWMY53NC?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dimethicone, Cyclopentasiloxane, Glycerin, Niacinamide, Ethylhexyl Methoxycrylene, Pentylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Tetrahexyldecyl Ascorbate, Thioctic Acid, Acetyl Tetrapeptide-9, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Bisabolol, Xanthan Gum, Hydrogenated Phosphatidylcholine, Mannitol, Benzyl Alcohol, Stearic Acid, Isohexadecane, Polysilicone-11, Polysorbate 60, Sorbitan Isostearate, Caprylic Capric Triglyceride, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Aluminum Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin