# Paula's Choice Clear Daily Skin Clearing Treatment for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Paula's Choice](https://lovi.care/skincare/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as benzoyl peroxide effectively targets acne-causing bacteria to reduce blemishes, while bisabolol and allantoin provide soothing benefits to mitigate potential dryness.
- The formula is well-balanced for acne-prone skin, with benzoyl peroxide in moderate concentrations to clear lesions and complementary ingredients to calm irritation.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/sensitive-skin): Caution
- [Acne-prone skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/mature-skin): Caution
- [Dry sensitive skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/oily-acne-prone-skin): Average

## Key ingredients

Benzoyl Peroxide, Salicylic Acid, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Bisabolol

## What the research says

- Topical benzoyl peroxide may improve acne more effectively than placebo or no treatment, while showing little to no difference compared with adapalene or clindamycin, but with an increased risk of treatment discontinuation due to adverse effects compared to placebo. ([The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/))
- Preoperative treatment with benzoyl peroxide significantly decreases the bacterial skin load of Cutibacterium acnes in patients undergoing elective shoulder surgery from skin incision until wound closure compared to preparation with soap. ([Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/))
- Once-daily fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel achieved superior treatment success (52.5%) and greater reductions in inflammatory and noninflammatory lesions compared to vehicle (8.1%) and dyad component gels in participants with moderate-to-severe acne over 12 weeks. ([American Journal of Clinical Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34674160/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel achieved significantly greater treatment success and lesion reductions compared to vehicle in participants with moderate-to-severe acne. ([Journal of the American Academy of Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37656094/))
- Daily application of adapalene 0.3%/benzoyl peroxide 2.5% gel reduced and prevented atrophic acne scar formation, achieving a total scar count change of -15.5% versus +14.4% for vehicle over 24 weeks in 67 subjects with moderate or severe facial acne. ([American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Glycyrrhiza glabra and Sophora japonica flavonoid-rich fractions individually and in combination significantly increased the wound healing rate and reduced oxidative stress compared to wound and Nolaver-treated groups. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37049756/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20642768/))
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate reduces UVB-induced PGE2, inflammatory cytokines, and mitochondrial superoxide in human epidermal keratinocytes. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38433250/))

## What reviewers say

This benzoyl peroxide treatment is highly effective at clearing acne, including cystic and hormonal types, with many users experiencing rapid results and a pleasant matte finish. A notable number of reviews mention that the product can be drying, necessitating the use of a good moisturizer to avoid flaking.

- Liked: Effective acne clearance (often mentioned)
- Liked: Fast acting (often mentioned)
- Disliked: Drying and flaking (often mentioned)
- Liked: Gentle formulation (sometimes noted)
- Liked: Long-lasting value (sometimes noted)
- Disliked: Bleaches fabrics (sometimes noted)
- Disliked: Expensive price (sometimes noted)
- Liked: Fades redness (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Sensitizing and stinging (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Paula's Choice Clear Daily Skin Clearing Treatment work for acne-prone skin?

This treatment works for acne-prone skin by using benzoyl peroxide to clear blemishes while soothing ingredients help calm irritation. Acne-prone skin needs products with ingredients like niacinamide, propolis, or zinc PCA that balance oil and provide hydration without causing dryness.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/)

### Which ingredients make this treatment a good fit for acne-prone skin?

This treatment works for acne-prone skin because benzoyl peroxide targets acne-causing bacteria to clear blemishes, while bisabolol and allantoin help calm irritation and dryness. However, acne-prone skin needs products with ingredients like niacinamide, propolis, and zinc PCA to provide balanced hydration and control oiliness.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/)

### What does Benzoyl Peroxide do for acne-prone skin?

Benzoyl Peroxide helps clear acne by targeting breakouts and reducing pimples, while also lowering the number of acne-causing bacteria. It may sometimes cause dryness or irritation, so pairing it with a gentle cleanser or moisturizer helps keep skin comfortable.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23839205/)

### What does Salicylic Acid do for acne-prone skin?

Salicylic acid helps clear acne-prone skin by reducing pimples and calming redness without causing many side effects. It works by dipping deep into pores to clear out blockages and control oil, making it a reliable choice for keeping skin smooth and clear.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine, as treatments with active ingredients are placed then for simplicity and extra safety around sun exposure. To fit acne-prone skin best, products of this type need ingredients that target blemishes while also including soothing components to calm irritation.

### Can I use this treatment with retinol, and in what order?

Using this treatment with retinol requires caution because combining two strong actives may easily dry out your skin, so you should apply them on alternating nights or use the retinol in the morning and this treatment at night. To keep acne-prone skin clear and calm, products of this type also need ingredients that gently exfoliate while soothing irritation and keeping the skin barrier hydrated.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### How often should I use this treatment?

You can use this treatment in your evening routine, applying it once a week at first and carefully increasing the frequency if your skin tolerates it well and shows good results. Topical benzoyl peroxide helps clear acne effectively, though it may carry an increased risk of treatment discontinuation due to side effects compared to a placebo.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/)

### Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores because benzoyl peroxide targets acne-causing bacteria to clear blemishes, while soothing ingredients help calm irritation. However, it can cause dryness and flaking, so acne-prone skin needs products with gentle, hydrating ingredients and calming components to maintain a smooth and comfortable feel.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — $15.50 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Benzoyl Peroxide, Propylene Glycol, Bisabolol, Allantoin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Hydroxyethylcellulose, Sodium Citrate, Laureth-4, Caprylyl Glycol, Sodium Hydroxide, Disodium Edta, Hexylene Glycol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin