# Paula's Choice 25% Vitamin C + Glutathione Clinical Serum for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Paula's Choice](https://lovi.care/skincare/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone for your oily skin due to the presence of tetrahexyldecyl ascorbate and glutathione, which provide antioxidant and brightening effects. Ascorbic acid and ergothioneine further support collagen synthesis and offer antioxidant protection, though these ingredients do not directly address oily shine.
- The formulation is safe for your oily skin as it lacks harsh ingredients and is unlikely to cause irritation.
- It provides general skincare benefits like hydration and antioxidant support, making it a suitable addition to your routine.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid, Glutathione, Ergothioneine, Ascorbyl Glucoside, Tocopherol

## What the research says

- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Many reviewers report a noticeable glow, improved skin bounce, and the fading of stubborn sun spots and post-inflammatory hyperpigmentation after consistent use.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective brightening (often mentioned)
- Liked: Elegant texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Heavy for oily (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Paula's Choice 25% Vitamin C + Glutathione Serum work for oily skin?

This serum works moderately well for oily skin by brightening your tone and providing antioxidant support, though it does not directly control oily shine. A treatment for this skin needs ingredients like niacinamide and zinc to manage excess oil and enlarged pores while keeping the skin balanced and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for oily skin?

This serum works for your oily skin because tetrahexyldecyl ascorbate and glutathione offer moderate brightening and antioxidant effects, while ascorbic acid and ergothioneine support collagen. To be a better fit for oily skin, a product of this type needs ingredients like niacinamide, ferulic acid, and zinc PCA to control sebum production and manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for oily skin?

Vitamin C helps brighten skin tone and smooth texture while providing antioxidant protection that prevents sebum oxidation. For oily skin, this type of product typically needs to be paired with oil-controlling or pore-clearing ingredients like salicylic acid or plant extracts.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492184/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Glutathione do for oily skin?

Glutathione helps protect oily skin from everyday damage and oxidative stress. It may also help keep your skin looking bright and smooth.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Where does this serum go in a skincare routine for oily skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Oily skin also benefits from ingredients that control shine and balance oil production.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying retinol first and following with this treatment, or by using one in the morning and the other at night. This formulation lacks harsh ingredients and is unlikely to cause irritation, making it a suitable addition to your routine. For oily skin, a product of this type needs lightweight hydrators and oil-controlling ingredients to keep shine in check while brightening.

### How often should I use this serum?

This treatment serum works well in the evening for your oily skin, and you can start using it once a week to see how your skin reacts. Nonprescription topical antioxidants serve as a low-risk addition to your routine and help brighten your skin tone safely over time.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to cause breakouts or clog pores on oily skin because it lacks harsh ingredients and has a safe profile, though an oily skin type also needs lightweight, oil-balancing ingredients that control shine.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — $28.88 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — $39.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — $15.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $70.00 (https://www.amazon.com/dp/B0CG2KD336?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Rice Bran Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco Caprylate Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract Sunflower Seed Extract, Urea, Mannitol, Caprylic Capric Triglyceride, Sodium Pca, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin