# Osmosis Skincare Renew Level 4 Vitamin A Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: Osmosis Skincare
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Excellent for your combination skin, this serum effectively targets oily shine with niacinamide to regulate sebum and retinal to refine texture and promote cell turnover. Palmitoyl tripeptide-38 further supports skin rejuvenation by boosting collagen synthesis.
- The inclusion of beta-glucan and asiaticoside provides soothing benefits, enhancing overall skin comfort and barrier support.
- This formula is safe for your skin, free from harsh irritants and containing beneficial ingredients like niacinamide and beta-glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/oily-acne-prone-skin): High

## Key ingredients

Vitamin A, Niacinamide, Retinal, Palmitoyl Tripeptide-38, Sodium Hyaluronate

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on limited data, users find this serum to be a highly effective anti-aging treatment that smooths fine lines and refines skin texture without causing irritation. It is frequently praised for its gentle, hydrating formula and its ability to deliver a noticeable glow. Some users report peeling if the product is overused, and a moderate number find the price point to be high.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective anti-aging (often mentioned)
- Liked: Improves texture & tone (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Dispenser issues (rarely noted)
- Disliked: Peeling if overused (rarely noted)
- Disliked: Yellow tint (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Osmosis Renew Level 4 Vitamin A Serum a great fit for combination skin?

This serum is a great fit because niacinamide and retinal target oily shine by regulating sebum and refining texture, while beta-glucan and asiaticoside calm and support the skin barrier. It also helps boost collagen to keep your combination skin smooth and youthful.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because niacinamide and retinal target oily shine and refine texture, while beta-glucan and asiaticoside calm and comfort the skin. Palmitoyl tripeptide-38 also helps support skin rejuvenation and collagen.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Vitamin A do for combination skin?

Vitamin A helps clear breakouts and smooth out rough patches on combination skin, but it may cause dryness or irritation at first. To work well for this skin type, a product of this type needs soothing ingredients and lightweight moisture to keep the skin calm and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32210603/), [Drugs & Aging, 1995](https://pubmed.ncbi.nlm.nih.gov/7663068/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing. Treatments with active ingredients are placed in the evening for simplicity and extra safety around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment serum at night, as using them at different times of day helps prevent potential irritation. Spacing them out allows both active ingredients to work effectively while keeping your skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

Use this treatment in your evening routine. Start by using it once a week, and if your skin tolerates it well and you see good results, you can carefully use it more often.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is a great fit for combination skin and is unlikely to clog pores or cause breakouts because it uses niacinamide to help regulate oily shine and retinal to smooth texture. It helps keep your skin clear while improving comfort and barrier support.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $92.00 (https://www.amazon.com/dp/B014DSPLK8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Pentylene Glycol, Niacinamide, Phosphatidylcholine, Glycerin, Asiaticoside, Cyclodextrin, Caprooyl Tetrapeptide-3, Chlorella Vulgaris Extract, Epilobium Angustifolium Stem Extract Flower Leaf, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Lactic Acid, Thioctic Acid, Fulvic Acid, Dimethyl Sulfone, Retinal, Beta-Glucan, Hydroxyproline, Grapefruit Peel Oil, Santalum Austrocaledonicum Oil Wood Sandalwood Oil Wood, Rubus Chamaemorus Berry Seed Oil Cloud Berry Seed Oil, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Dextran, Hydroxypropyl Cyclodextrin, Xanthan Gum, Alcohol Denat, Potassium Sorbate, Sodium Hydroxide, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin