# Olay Regenerist Retinol 24 Night Moisturizer for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Olay](https://lovi.care/skincare/brands/olay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for normal skin, as niacinamide and retinol offer antioxidant activity and desquamation regulation, respectively, addressing your concerns with wrinkles and fine lines. Glycerin and sodium hyaluronate provide excellent moisturization, hydrating and plumping the skin to further enhance wrinkle reduction.
- Palmitoyl pentapeptide-4 and aminopropyl ascorbyl phosphate work synergistically to promote collagen production and skin regeneration, supporting the anti-aging benefits.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/oily-acne-prone-skin): High

## Key ingredients

Retinol, Sodium Hyaluronate, Niacinamide, Glycerin, Peptides

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users consistently praise this moisturizer for its ability to make skin feel noticeably smoother, softer, and brighter overnight without the irritation often associated with retinol. Many appreciate the fragrance-free, non-greasy formula that absorbs quickly, though a subset of users experienced breakouts or found the jar packaging unhygienic.

- Liked: Smoother, softer skin (mostly mentioned)
- Liked: Gentle & fragrance-free (often mentioned)
- Liked: Lightweight & non-greasy (often mentioned)
- Liked: Visible brightening (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging concerns (rarely noted)
- Disliked: Unpleasant smell (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Olay Regenerist Retinol 24 Night Moisturizer one of the best fits for mature skin?

Olay Regenerist Retinol 24 Night Moisturizer is one of the best fits for mature skin because retinol and niacinamide help smooth out wrinkles and fine lines, while glycerin and sodium hyaluronate keep your skin deeply hydrated and plump. It also contains peptides and vitamin C derivatives that support skin regeneration and help your skin stay firm and smooth. The gentle formula is very safe for your skin with virtually no risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Niacinamide and retinol help smooth fine lines, while glycerin and sodium hyaluronate keep your skin hydrated and plump. Additionally, peptides and vitamin A derivatives support collagen production to help fight the signs of aging.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes in the evening routine as a treatment step after cleansing and toning. It is safe for mature skin and helps smooth fine lines while deeply hydrating.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with vitamin C, and in what order?

You can use this cream alongside vitamin C by applying your vitamin C product in the morning and saving this retinol treatment for your nighttime routine. This order helps you get the anti-aging benefits of both ingredients without overwhelming your skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this cream?

Use this moisturizing treatment in your evening routine. Daily application helps smooth fine lines and improves skin hydration and firmness.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very low number of complaints about this issue. The formula is designed to be gentle while helping smooth fine lines.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well suited for mature skin, but because the skin around the eyes and on certain body areas is very thin, a gentler approach may be needed for those sensitive spots. While the ingredients help smooth lines and provide deep hydration, you should test a small area first to ensure your skin tolerates it comfortably.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol, stearyl alcohol, and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — $125.00 at Amazon
- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — $21.55 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — $149.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

- Amazon.com: $35.99 (https://www.amazon.com/dp/B08CD979ZS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dimethicone, Glycerin, Niacinamide, Retinol, Aminopropyl Ascorbyl Phosphate, Palmitoyl Pentapeptide-4, Sodium Hyaluronate, Tocopheryl Acetate, Panthenol, Cetyl Alcohol, Stearyl Alcohol, Cetearyl Glucoside, Cetearyl Alcohol, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Dimethiconol, Caprylyl Glycol, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- France: https://lovi.care/skincare/fr/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin