# Obagi Professional-C Serum 20% for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Obagi](https://lovi.care/skincare/brands/obagi)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent brightening and antioxidant protection for your combination skin, as ascorbic acid and ascorbyl glucoside work to even skin tone and shield from environmental stressors.
- The formula is highly suitable for your oily shine concerns, with these key ingredients also supporting collagen synthesis.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Ascorbyl Glucoside, Zinc Chloride, Propylene Glycol

## What the research says

- Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- An aloe-alginate film dressing showed no statistical difference in wound contraction but demonstrated anti-inflammatory activity, stimulated angiogenesis, and increased collagen type I fibers while decreasing type III fibers compared to sterile gauze in rats with incisional skin wounds. ([Acta Cirurgica Brasileira, 2020](https://pubmed.ncbi.nlm.nih.gov/32638846/))
- Treatment with a combination of propylene glycol, ethanol, water, and shampoo was found effective, easy to use, and cosmetically attractive with no observed side effects in patients with dandruff. ([Cutis, 1988](https://pubmed.ncbi.nlm.nih.gov/2970946/))
- A moisturizer containing glycerol and propylene glycol reduced transepidermal water loss, decreased epidermal thickness, increased stratum corneum thickness, and reduced dermal inflammatory infiltrate compared to untreated disrupted skin in six healthy beagle dogs. ([Veterinary Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32628309/))

## What reviewers say

Based on a very large amount of data, users with normal to oily skin report this high-potency serum provides a significant glow and brightens the complexion while improving skin texture. Many reviewers praise its effectiveness in fading hyperpigmentation, acne scars, and sun spots. Some users note it can be drying or irritating for sensitive skin types.

- Liked: Brightens complexion (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Smoothes skin texture (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Oxidizes quickly (sometimes noted)
- Liked: Reduces fine lines (rarely noted)
- Disliked: Causes dryness/irritation (rarely noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Obagi Professional-C Serum 20% a great fit for combination skin?

This serum is a great fit because it offers excellent brightening and antioxidant protection, using ascorbic acid and ascorbyl glucoside to even skin tone and shield your skin from environmental stressors. The formula is also well suited for oily shine concerns while supporting collagen synthesis, and it is safe for your skin without risks of irritation.
Sources: [International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for combination skin?

Ascorbic acid and ascorbyl glucoside make this serum a great fit by brightening your skin, evening out your skin tone, and shielding against daily environmental stress. Sodium hyaluronate also helps support your skin while keeping it smooth and balanced.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for combination skin?

Vitamin C helps brighten dull areas and smooth out uneven texture on combination skin while protecting against daily environmental stress. It may also help keep pores clear and skin firm by supporting collagen production, though drier spots may need an added moisturizer to stay comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does it go in a skincare routine for combination skin?

This treatment goes in the evening routine for your combination skin, used after cleansing and toning and before moisturizing. Putting it in the evening helps keep things simple and offers extra safety around sun exposure, though some treatments like this can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this vitamin C serum in your morning routine and your retinol at night to avoid overwhelming your skin. This spacing helps prevent irritation while still giving you the brightening and smoothing benefits of both ingredients.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use it?

You can use this treatment in your evening routine, and some of them may also be used in the morning or twice a day. Antioxidant treatments like this serve as a low-risk mainstay intervention for skin rejuvenation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin. It features a gentle formula that steers clear of harsh ingredients, keeping your skin safe from irritation.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $155.00 (https://www.amazon.com/dp/B00F6XZZMY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Propylene Glycol, Water, Ascorbic Acid, Alcohol, Ascorbyl Glucoside, Ethoxydiglycol, Phenoxyethanol, Sorbitol, Sodium Hyaluronate, Zinc Chloride, Calcium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/obagi/professional-c-serum-20/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/obagi/professional-c-serum-20/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/obagi/professional-c-serum-20/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/obagi/professional-c-serum-20/for/combination-skin
- France: https://lovi.care/skincare/fr/p/obagi/professional-c-serum-20/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/obagi/professional-c-serum-20/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/obagi/professional-c-serum-20/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/obagi/professional-c-serum-20/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/obagi/professional-c-serum-20/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/obagi/professional-c-serum-20/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/obagi/professional-c-serum-20/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/obagi/professional-c-serum-20/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/obagi/professional-c-serum-20/for/combination-skin