# No7 Protect & Perfect Intense Advanced Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [No7](https://lovi.care/skincare/brands/no7)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin, as Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7 work to minimize fine lines and wrinkles, while Sodium Hyaluronate and Glycerin provide essential hydration.
- The inclusion of Tocopherol and Retinyl Palmitate offers additional antioxidant protection and skin renewal, supporting overall skin health.
- The product is safe for your normal skin, with no reported risks of irritation due to its gentle formulation and absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Ascorbyl Phosphate, Retinyl Palmitate, Acetyl Dipeptide-1 Cetyl Ester, Hydrolyzed Rice Protein, Dimethicone

## What the research says

- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate. ([Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/))
- A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Cosmetic products containing 4-t-butylcyclohexanol demonstrated a faster and more pronounced soothing effect on capsaicin-induced burning compared to those containing acetyl dipeptide-1 cetyl ester in volunteers with sensitive skin. ([Journal of the European Academy of Dermatology and Venereology, 2016](https://pubmed.ncbi.nlm.nih.gov/26805418/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## What reviewers say

Based on a very large amount of data, users with aging, dry, or combination skin frequently praise this serum for its silky texture and ability to instantly smooth and hydrate the skin. While many report visible improvements in fine lines and overall radiance after consistent use, results regarding deep wrinkles are mixed, with some users seeing significant firming and others noticing little change.

- Liked: Instant skin smoothing (mostly mentioned)
- Liked: Silky, lightweight texture (mostly mentioned)
- Liked: Quick absorption (often mentioned)
- Liked: Hydration and radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Lack of visible results (sometimes noted)
- Disliked: Silicone-heavy feel (sometimes noted)
- Disliked: Greasiness (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Protect & Perfect Intense Advanced Serum work for mature skin?

This serum works well for mature skin, offering moderate anti-aging benefits and essential hydration to help smooth out fine lines and wrinkles. However, a product of this type needs exceptional safety with no risk of irritation, highly effective wrinkle-targeting ingredients, and optimal suitability for maintaining skin elasticity and moisture.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### Which ingredients make this serum a good fit for mature skin?

This serum works well for mature skin because it contains peptides like palmitoyl oligopeptide and palmitoyl tetrapeptide-7 that help smooth out fine lines and wrinkles. It also includes sodium hyaluronate and glycerin to provide essential hydration, alongside retinyl palmitate and tocopherol for antioxidant protection and skin renewal. To achieve an even better fit for mature skin, a product of this type needs exceptionally safe and high-quality anti-aging ingredients that target wrinkles effectively while keeping the skin completely free from irritation.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by boosting collagen production, which softens wrinkles and improves elasticity for a smoother look. It also protects against daily damage and brightens dark spots to keep your complexion even and glowing.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/), [The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29104718/)

### What does Retinyl Palmitate do for mature skin?

Retinyl palmitate helps smooth out fine lines and wrinkles on mature skin while improving overall firmness, texture, and dryness. It may also help protect against sun-induced aging by supporting skin structure and reducing collagen breakdown.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing. Mature skin needs products containing peptides and antioxidants to help smooth fine lines and support overall skin health.

### Can I use this serum with retinol, and in what order?

You can use this serum with a retinol, but apply this treatment first and follow with your retinol product. Because both ingredients help smooth fine lines, using them together may occasionally cause mild dryness, so it is best to introduce them slowly.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### How often should I use this serum?

This serum works well when used in the evening as part of your routine. A mature skin type needs a product of this type that also delivers powerful antioxidants and firming peptides to effectively smooth fine lines and keep the skin soft.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clogging for mature skin, as it has a gentle formulation with a low risk of irritation. A product of this type needs peptides like palmitoyl oligopeptide and palmitoyl tetrapeptide-7, along with hydrating ingredients like sodium hyaluronate and glycerin, to support mature skin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — $810.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

- Amazon.com: $37.99 (https://www.amazon.com/dp/B07CKM5L1T?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Acetyl Dipeptide-1 Cetyl Ester, Water, Butylene Glycol, Carbomer, Cetyl Peg Ppg-10 1 Dimethicone, Dimethicone, Dimethicone Crosspolymer, Ethylhexylglycerin, Ethylparaben, Glycerin, Hexyl Laurate, Hydrolyzed Rice Protein, Hydroxyethylcellulose, Magnesium Sulfate, Medicago Sativa Extract, Methylparaben, Morus Alba Leaf Extract, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Panax Ginseng Root Extract, Peg Ppg-18 18 Dimethicone, Phenoxyethanol, Polyglyceryl-4 Isostearate, Polysorbate 20, Propylene Glycol, Retinyl Palmitate, Sodium Ascorbyl Phosphate, Sodium Benzoate, Sodium Hyaluronate, Sorbitan Laurate, Tocopherol, Tocopheryl Acetate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/no7/protect-and-perfect-intense-advanced-serum/for/mature-skin