# NEOCUTIS Bio Serum Firm for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [NEOCUTIS](https://lovi.care/skincare/brands/neocutis)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry and sensitive skin, this serum effectively addresses dryness and flakiness with humectants like glycerin and sodium hyaluronate, while peptides such as Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate promote a plumping effect. Squalane further supports your skin barrier, enhancing overall hydration and resilience.
- The inclusion of Aminopropyl Ascorbyl Phosphate offers antioxidant benefits, complementing the hydrating ingredients for comprehensive skin health.
- This formula is safe for your dry and sensitive skin, containing no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/oily-acne-prone-skin): Average

## Key ingredients

Rejuvenating Growth Factor, Peptides, Sodium Hyaluronate, Acetyl Glucosamine, Aminopropyl Ascorbyl Phosphate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Users frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating and Plumping (often mentioned)
- Liked: Improves Skin Texture (often mentioned)
- Liked: Reduces Fine Lines (often mentioned)
- Liked: Fast Results (sometimes noted)
- Liked: Gentle on Skin (sometimes noted)
- Disliked: Irritation/Reactions (rarely noted)
- Disliked: Lack of Results (rarely noted)
- Disliked: Product Pilling (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Neocutis Bio Serum Firm a great fit for dry sensitive skin?

Neocutis Bio Serum Firm is a great fit because it tackles dryness and flakiness with hydrating ingredients like glycerin and sodium hyaluronate, while squalane supports your skin barrier to keep it soft and resilient. It also features peptides that help plump the skin and gentle antioxidants for added support, all in a formula that contains no harsh irritants.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

This serum is a great fit for your dry sensitive skin because it uses glycerin and sodium hyaluronate to tackle dryness and flakiness. It also includes squalane to support your skin barrier and peptides like Tetrapeptide-21 to help plump the skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Growth Factor do for dry sensitive skin?

Growth Factor helps repair the skin barrier and supports moisture recovery for dry and sensitive skin. It works by encouraging surface renewal and decreasing moisture loss, though individual results may vary.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23108135/), [International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/36232814/)

### What do Peptides do for dry sensitive skin?

Peptides help hydrate dry sensitive skin while smoothing the look of fine lines and keeping the surface calm. They may also improve skin elasticity, though some types need enhanced delivery systems to deeply penetrate the skin barrier.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Putting treatments in the evening helps keep your routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to hydrate your skin and calm dryness before layering retinol on top. This gentle formula is unlikely to cause irritation, but if your skin is extra sensitive, you may want to use them on alternate nights.

### How often should I use this serum?

This serum fits into your evening routine as a nightly treatment step. It helps soothe dry, flaky areas and supports your skin barrier safely without harsh ingredients.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of heavy, pore-clogging oils and harsh irritants. Its hydrating ingredients and squalane help nourish your skin barrier without triggering blemishes or purging.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — $39.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neocutis/bio-serum-firm/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neocutis/bio-serum-firm/for/dry-sensitive-skin