# NEOCUTIS Bio Serum Firm for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [NEOCUTIS](https://lovi.care/skincare/brands/neocutis)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Offers excellent firming and plumping for your combination skin due to peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, which also provide moderate antioxidant benefits to address oily shine.
- Glycerin and Sodium Hyaluronate offer humectant action, supporting hydration for your combination skin type.
- The formulation is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/oily-acne-prone-skin): Average

## Key ingredients

Rejuvenating Growth Factor, Peptides, Sodium Hyaluronate, Acetyl Glucosamine, Aminopropyl Ascorbyl Phosphate

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Users frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating and Plumping (often mentioned)
- Liked: Improves Skin Texture (often mentioned)
- Liked: Reduces Fine Lines (often mentioned)
- Liked: Fast Results (sometimes noted)
- Liked: Gentle on Skin (sometimes noted)
- Disliked: Irritation/Reactions (rarely noted)
- Disliked: Lack of Results (rarely noted)
- Disliked: Product Pilling (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Neocutis Bio-Serum Firm a great fit for combination skin?

Neocutis Bio-Serum Firm is a great fit because its peptides provide excellent firming and plumping while offering moderate antioxidant benefits to address oily shine. Glycerin and Sodium Hyaluronate draw in moisture to support balanced hydration, and the gentle formula is very unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate offer firming, plumping, and moderate antioxidant benefits that help address oily shine. Glycerin and Sodium Hyaluronate also support hydration, and the formula is safe with no risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Growth Factor do for combination skin?

Growth Factor helps smooth fine lines and improves overall skin texture for a more even look. This type of product works best when it includes hydrating ingredients and lightweight hydrators to balance combination skin without feeling heavy.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37222303/), [Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27877059/)

### What do Peptides do for combination skin?

Peptides help combination skin by keeping it smooth, supporting firmness, and boosting hydration. They also help reduce the appearance of lines and encourage skin repair, though absorption depends on the formula.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [Food & Function, 2019](https://pubmed.ncbi.nlm.nih.gov/31497829/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. It is safe for combination skin and is unlikely to cause irritation.

### Can I use it with retinol, and in what order?

You can use this serum with retinol by applying your retinol product first at night, letting it absorb, and then applying this treatment afterwards. This combination is generally safe and unlikely to cause irritation when introduced gradually.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is a great fit for your combination skin, helping to firm and plump while keeping your skin calm and hydrated without irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Can it clog pores, cause breakouts or purging for combination skin?

Neocutis Bio Serum Firm is unlikely to clog pores or cause breakouts on combination skin, as it has a very low risk of irritation and features a balanced formula without harsh ingredients. The serum helps keep skin smooth and hydrated while addressing signs of aging safely.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neocutis/bio-serum-firm/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/neocutis/bio-serum-firm/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/neocutis/bio-serum-firm/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/neocutis/bio-serum-firm/for/combination-skin
- France: https://lovi.care/skincare/fr/p/neocutis/bio-serum-firm/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/neocutis/bio-serum-firm/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/neocutis/bio-serum-firm/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/neocutis/bio-serum-firm/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/neocutis/bio-serum-firm/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/neocutis/bio-serum-firm/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/neocutis/bio-serum-firm/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neocutis/bio-serum-firm/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neocutis/bio-serum-firm/for/combination-skin